Zinc in PDB 8tug: Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State)
Enzymatic activity of Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State)
All present enzymatic activity of Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State):
2.7.7.6;
Other elements in 8tug:
The structure of Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State) also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State)
(pdb code 8tug). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 8 binding sites of Zinc where determined in the
Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State), PDB code: 8tug:
Jump to Zinc binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Zinc binding site 1 out
of 8 in 8tug
Go back to
Zinc Binding Sites List in 8tug
Zinc binding site 1 out
of 8 in the Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State)
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1801
b:186.1
occ:1.00
|
H
|
A:CYS110
|
2.1
|
162.0
|
1.0
|
|
O
|
A:MET108
|
2.1
|
156.1
|
1.0
|
|
N
|
A:CYS110
|
2.2
|
162.0
|
1.0
|
|
SG
|
A:CYS167
|
2.3
|
166.9
|
1.0
|
|
C
|
A:HIS109
|
2.4
|
157.1
|
1.0
|
|
HB2
|
A:CYS110
|
2.6
|
162.0
|
1.0
|
|
C
|
A:MET108
|
2.6
|
156.1
|
1.0
|
|
HB2
|
A:HIS109
|
2.7
|
157.1
|
1.0
|
|
O
|
A:CYS107
|
2.8
|
162.4
|
1.0
|
|
CA
|
A:HIS109
|
2.9
|
157.1
|
1.0
|
|
N
|
A:HIS109
|
2.9
|
157.1
|
1.0
|
|
HB2
|
A:CYS167
|
2.9
|
166.9
|
1.0
|
|
O
|
A:HIS109
|
3.1
|
157.1
|
1.0
|
|
CA
|
A:CYS110
|
3.1
|
162.0
|
1.0
|
|
CB
|
A:CYS110
|
3.2
|
162.0
|
1.0
|
|
CB
|
A:CYS167
|
3.2
|
166.9
|
1.0
|
|
CB
|
A:HIS109
|
3.3
|
157.1
|
1.0
|
|
HB3
|
A:CYS110
|
3.4
|
162.0
|
1.0
|
|
HA
|
A:CYS110
|
3.4
|
162.0
|
1.0
|
|
HB3
|
A:CYS167
|
3.5
|
166.9
|
1.0
|
|
C
|
A:CYS107
|
3.6
|
162.4
|
1.0
|
|
H
|
A:HIS109
|
3.6
|
157.1
|
1.0
|
|
HA
|
A:HIS109
|
3.8
|
157.1
|
1.0
|
|
CA
|
A:MET108
|
3.8
|
156.1
|
1.0
|
|
HB3
|
A:CYS107
|
4.0
|
162.4
|
1.0
|
|
ND1
|
A:HIS109
|
4.0
|
157.1
|
1.0
|
|
N
|
A:MET108
|
4.0
|
156.1
|
1.0
|
|
HB3
|
A:HIS109
|
4.1
|
157.1
|
1.0
|
|
CG
|
A:HIS109
|
4.1
|
157.1
|
1.0
|
|
HD21
|
A:ASN169
|
4.3
|
163.1
|
1.0
|
|
HB2
|
A:MET108
|
4.3
|
156.1
|
1.0
|
|
HE21
|
A:GLN171
|
4.4
|
160.7
|
1.0
|
|
H
|
A:GLY111
|
4.4
|
155.1
|
1.0
|
|
H
|
A:CYS167
|
4.4
|
166.9
|
1.0
|
|
OD1
|
A:ASN169
|
4.5
|
163.1
|
1.0
|
|
C
|
A:CYS110
|
4.5
|
162.0
|
1.0
|
|
CB
|
A:MET108
|
4.5
|
156.1
|
1.0
|
|
HB3
|
A:MET108
|
4.5
|
156.1
|
1.0
|
|
CA
|
A:CYS167
|
4.6
|
166.9
|
1.0
|
|
HA
|
A:MET108
|
4.6
|
156.1
|
1.0
|
|
CB
|
A:CYS107
|
4.6
|
162.4
|
1.0
|
|
HB2
|
A:CYS107
|
4.6
|
162.4
|
1.0
|
|
H
|
A:MET108
|
4.7
|
156.1
|
1.0
|
|
CA
|
A:CYS107
|
4.8
|
162.4
|
1.0
|
|
N
|
A:GLY111
|
4.8
|
155.1
|
1.0
|
|
SG
|
A:CYS110
|
4.8
|
162.0
|
1.0
|
|
HE22
|
A:GLN171
|
4.8
|
160.7
|
1.0
|
|
HA
|
A:CYS167
|
4.9
|
166.9
|
1.0
|
|
N
|
A:CYS167
|
4.9
|
166.9
|
1.0
|
|
SG
|
A:CYS148
|
4.9
|
167.8
|
1.0
|
|
NE2
|
A:GLN171
|
4.9
|
160.7
|
1.0
|
|
ND2
|
A:ASN169
|
5.0
|
163.1
|
1.0
|
|
Zinc binding site 2 out
of 8 in 8tug
Go back to
Zinc Binding Sites List in 8tug
Zinc binding site 2 out
of 8 in the Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State)
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1802
b:161.8
occ:1.00
|
HB2
|
A:CYS70
|
1.5
|
139.3
|
1.0
|
|
HB3
|
A:CYS67
|
1.8
|
142.9
|
1.0
|
|
O
|
A:CYS67
|
2.0
|
142.9
|
1.0
|
|
CB
|
A:CYS70
|
2.1
|
139.3
|
1.0
|
|
NE2
|
A:HIS80
|
2.3
|
124.1
|
1.0
|
|
SG
|
A:CYS70
|
2.3
|
139.3
|
1.0
|
|
SG
|
A:CYS77
|
2.3
|
127.4
|
1.0
|
|
HB2
|
A:CYS67
|
2.4
|
142.9
|
1.0
|
|
CB
|
A:CYS67
|
2.5
|
142.9
|
1.0
|
|
HB3
|
A:CYS70
|
2.6
|
139.3
|
1.0
|
|
C
|
A:CYS67
|
3.0
|
142.9
|
1.0
|
|
H
|
A:CYS70
|
3.1
|
139.3
|
1.0
|
|
CE1
|
A:HIS80
|
3.2
|
124.1
|
1.0
|
|
CA
|
A:CYS67
|
3.3
|
142.9
|
1.0
|
|
CD2
|
A:HIS80
|
3.3
|
124.1
|
1.0
|
|
HE1
|
A:HIS80
|
3.4
|
124.1
|
1.0
|
|
CA
|
A:CYS70
|
3.4
|
139.3
|
1.0
|
|
HD2
|
A:HIS80
|
3.5
|
124.1
|
1.0
|
|
N
|
A:CYS70
|
3.7
|
139.3
|
1.0
|
|
HA
|
A:CYS67
|
3.8
|
142.9
|
1.0
|
|
CB
|
A:CYS77
|
3.9
|
127.4
|
1.0
|
|
HB2
|
A:CYS77
|
4.0
|
127.4
|
1.0
|
|
SG
|
A:CYS67
|
4.0
|
142.9
|
1.0
|
|
HG
|
A:CYS67
|
4.0
|
142.9
|
1.0
|
|
HA
|
A:CYS70
|
4.1
|
139.3
|
1.0
|
|
N
|
A:GLN68
|
4.2
|
134.8
|
1.0
|
|
O
|
A:PRO78
|
4.2
|
114.5
|
1.0
|
|
C
|
A:CYS70
|
4.2
|
139.3
|
1.0
|
|
OE1
|
A:GLN68
|
4.2
|
134.8
|
1.0
|
|
HB3
|
A:GLN68
|
4.3
|
134.8
|
1.0
|
|
HB3
|
A:CYS77
|
4.3
|
127.4
|
1.0
|
|
O
|
A:LYS66
|
4.3
|
138.3
|
1.0
|
|
ND1
|
A:HIS80
|
4.4
|
124.1
|
1.0
|
|
N
|
A:CYS67
|
4.4
|
142.9
|
1.0
|
|
CG
|
A:HIS80
|
4.4
|
124.1
|
1.0
|
|
O
|
A:GLN71
|
4.6
|
138.7
|
1.0
|
|
C
|
A:GLN68
|
4.6
|
134.8
|
1.0
|
|
O
|
A:GLN68
|
4.7
|
134.8
|
1.0
|
|
HA2
|
A:GLY59
|
4.7
|
134.2
|
1.0
|
|
H
|
A:GLN71
|
4.7
|
138.7
|
1.0
|
|
N
|
A:GLN71
|
4.7
|
138.7
|
1.0
|
|
C
|
A:LYS66
|
4.8
|
138.3
|
1.0
|
|
O
|
A:CYS70
|
4.8
|
139.3
|
1.0
|
|
CA
|
A:GLN68
|
4.8
|
134.8
|
1.0
|
|
H
|
A:GLN68
|
4.9
|
134.8
|
1.0
|
|
C
|
A:THR69
|
5.0
|
140.3
|
1.0
|
|
CA
|
A:CYS77
|
5.0
|
127.4
|
1.0
|
|
Zinc binding site 3 out
of 8 in 8tug
Go back to
Zinc Binding Sites List in 8tug
Zinc binding site 3 out
of 8 in the Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State)
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn1301
b:140.5
occ:1.00
|
SG
|
B:CYS1182
|
2.3
|
127.5
|
1.0
|
|
SG
|
B:CYS1166
|
2.3
|
116.5
|
1.0
|
|
SG
|
B:CYS1185
|
2.3
|
125.9
|
1.0
|
|
SG
|
B:CYS1163
|
2.3
|
116.4
|
1.0
|
|
HB2
|
B:CYS1185
|
2.7
|
125.9
|
1.0
|
|
HB3
|
B:CYS1163
|
2.7
|
116.4
|
1.0
|
|
CB
|
B:CYS1163
|
2.9
|
116.4
|
1.0
|
|
HB2
|
B:CYS1163
|
3.0
|
116.4
|
1.0
|
|
CB
|
B:CYS1185
|
3.1
|
125.9
|
1.0
|
|
H
|
B:CYS1166
|
3.1
|
116.5
|
1.0
|
|
HB3
|
B:CYS1185
|
3.4
|
125.9
|
1.0
|
|
HB3
|
B:CYS1166
|
3.5
|
116.5
|
1.0
|
|
HB3
|
B:CYS1182
|
3.5
|
127.5
|
1.0
|
|
CB
|
B:CYS1166
|
3.5
|
116.5
|
1.0
|
|
CB
|
B:CYS1182
|
3.6
|
127.5
|
1.0
|
|
HB
|
B:ILE1165
|
3.6
|
120.6
|
1.0
|
|
N
|
B:CYS1166
|
3.8
|
116.5
|
1.0
|
|
HB2
|
B:CYS1182
|
3.8
|
127.5
|
1.0
|
|
O
|
B:CYS1166
|
4.2
|
116.5
|
1.0
|
|
HG23
|
B:THR1170
|
4.2
|
117.8
|
1.0
|
|
CA
|
B:CYS1166
|
4.2
|
116.5
|
1.0
|
|
HB2
|
B:CYS1166
|
4.3
|
116.5
|
1.0
|
|
CA
|
B:CYS1163
|
4.4
|
116.4
|
1.0
|
|
CA
|
B:CYS1185
|
4.4
|
125.9
|
1.0
|
|
HG21
|
B:THR1170
|
4.5
|
117.8
|
1.0
|
|
H
|
B:CYS1185
|
4.5
|
125.9
|
1.0
|
|
CB
|
B:ILE1165
|
4.5
|
120.6
|
1.0
|
|
HB3
|
B:ASN1187
|
4.6
|
130.2
|
1.0
|
|
H
|
B:ILE1165
|
4.6
|
120.6
|
1.0
|
|
N
|
B:CYS1185
|
4.6
|
125.9
|
1.0
|
|
C
|
B:CYS1166
|
4.7
|
116.5
|
1.0
|
|
HG22
|
B:THR1170
|
4.7
|
117.8
|
1.0
|
|
CG2
|
B:THR1170
|
4.7
|
117.8
|
1.0
|
|
HB2
|
B:LEU1168
|
4.7
|
113.5
|
1.0
|
|
HA
|
B:CYS1163
|
4.8
|
116.4
|
1.0
|
|
C
|
B:ILE1165
|
4.8
|
120.6
|
1.0
|
|
O
|
B:CYS1182
|
4.8
|
127.5
|
1.0
|
|
HA
|
B:CYS1185
|
4.8
|
125.9
|
1.0
|
|
CA
|
B:CYS1182
|
4.9
|
127.5
|
1.0
|
|
C
|
B:CYS1163
|
4.9
|
116.4
|
1.0
|
|
H
|
B:CYS1163
|
5.0
|
116.4
|
1.0
|
|
HG12
|
B:ILE1165
|
5.0
|
120.6
|
1.0
|
|
Zinc binding site 4 out
of 8 in 8tug
Go back to
Zinc Binding Sites List in 8tug
Zinc binding site 4 out
of 8 in the Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State)
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Zn401
b:165.2
occ:1.00
|
SG
|
C:CYS88
|
2.3
|
136.5
|
1.0
|
|
SG
|
C:CYS86
|
2.3
|
131.2
|
1.0
|
|
SG
|
C:CYS92
|
2.3
|
125.3
|
1.0
|
|
SG
|
C:CYS95
|
2.3
|
122.7
|
1.0
|
|
HB3
|
C:CYS88
|
2.7
|
136.5
|
1.0
|
|
HB3
|
C:CYS86
|
3.0
|
131.2
|
1.0
|
|
CB
|
C:CYS88
|
3.1
|
136.5
|
1.0
|
|
HB3
|
C:CYS92
|
3.1
|
125.3
|
1.0
|
|
HB3
|
C:CYS95
|
3.2
|
122.7
|
1.0
|
|
CB
|
C:CYS86
|
3.2
|
131.2
|
1.0
|
|
CB
|
C:CYS92
|
3.3
|
125.3
|
1.0
|
|
CB
|
C:CYS95
|
3.4
|
122.7
|
1.0
|
|
H
|
C:CYS92
|
3.4
|
125.3
|
1.0
|
|
H
|
C:CYS88
|
3.5
|
136.5
|
1.0
|
|
H
|
C:CYS95
|
3.6
|
122.7
|
1.0
|
|
HB2
|
C:CYS86
|
3.6
|
131.2
|
1.0
|
|
N
|
C:CYS92
|
3.6
|
125.3
|
1.0
|
|
HB2
|
C:CYS88
|
3.7
|
136.5
|
1.0
|
|
HB3
|
C:LYS94
|
3.7
|
123.6
|
1.0
|
|
N
|
C:CYS95
|
3.9
|
122.7
|
1.0
|
|
HA
|
C:HIS91
|
3.9
|
122.3
|
1.0
|
|
CA
|
C:CYS92
|
4.0
|
125.3
|
1.0
|
|
HB2
|
C:CYS92
|
4.1
|
125.3
|
1.0
|
|
HB2
|
C:CYS95
|
4.1
|
122.7
|
1.0
|
|
H
|
C:LYS94
|
4.2
|
123.6
|
1.0
|
|
N
|
C:CYS88
|
4.2
|
136.5
|
1.0
|
|
CA
|
C:CYS88
|
4.2
|
136.5
|
1.0
|
|
CA
|
C:CYS95
|
4.2
|
122.7
|
1.0
|
|
C
|
C:HIS91
|
4.2
|
122.3
|
1.0
|
|
C
|
C:CYS92
|
4.5
|
125.3
|
1.0
|
|
CA
|
C:HIS91
|
4.6
|
122.3
|
1.0
|
|
CA
|
C:CYS86
|
4.6
|
131.2
|
1.0
|
|
C
|
C:LYS94
|
4.6
|
123.6
|
1.0
|
|
CB
|
C:LYS94
|
4.6
|
123.6
|
1.0
|
|
N
|
C:LYS94
|
4.7
|
123.6
|
1.0
|
|
O
|
C:CYS92
|
4.8
|
125.3
|
1.0
|
|
HG
|
C:SER96
|
4.8
|
115.1
|
1.0
|
|
HA
|
C:CYS92
|
4.8
|
125.3
|
1.0
|
|
C
|
C:CYS86
|
4.9
|
131.2
|
1.0
|
|
C
|
C:CYS88
|
4.9
|
136.5
|
1.0
|
|
CA
|
C:LYS94
|
4.9
|
123.6
|
1.0
|
|
C
|
C:CYS95
|
4.9
|
122.7
|
1.0
|
|
O
|
C:CYS88
|
4.9
|
136.5
|
1.0
|
|
HA
|
C:CYS88
|
5.0
|
136.5
|
1.0
|
|
O
|
C:HIS91
|
5.0
|
122.3
|
1.0
|
|
Zinc binding site 5 out
of 8 in 8tug
Go back to
Zinc Binding Sites List in 8tug
Zinc binding site 5 out
of 8 in the Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State)
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 5 of Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
I:Zn201
b:252.2
occ:1.00
|
HA
|
I:CYS32
|
2.1
|
220.7
|
1.0
|
|
O
|
I:THR31
|
2.3
|
212.0
|
1.0
|
|
SG
|
I:CYS7
|
2.3
|
216.8
|
1.0
|
|
SG
|
I:CYS10
|
2.3
|
216.8
|
1.0
|
|
HB2
|
I:CYS32
|
2.8
|
220.7
|
1.0
|
|
HB2
|
I:CYS10
|
2.8
|
216.8
|
1.0
|
|
CA
|
I:CYS32
|
2.9
|
220.7
|
1.0
|
|
OD1
|
I:ASP9
|
2.9
|
217.3
|
1.0
|
|
C
|
I:THR31
|
3.1
|
212.0
|
1.0
|
|
CB
|
I:CYS10
|
3.1
|
216.8
|
1.0
|
|
CB
|
I:CYS32
|
3.2
|
220.7
|
1.0
|
|
N
|
I:CYS32
|
3.3
|
220.7
|
1.0
|
|
CB
|
I:CYS7
|
3.6
|
216.8
|
1.0
|
|
HB2
|
I:CYS7
|
3.6
|
216.8
|
1.0
|
|
HB3
|
I:CYS10
|
3.7
|
216.8
|
1.0
|
|
HB3
|
I:CYS7
|
3.8
|
216.8
|
1.0
|
|
H
|
I:SER33
|
3.9
|
221.2
|
1.0
|
|
SG
|
I:CYS32
|
4.0
|
220.7
|
1.0
|
|
H
|
I:CYS10
|
4.1
|
216.8
|
1.0
|
|
CG
|
I:ASP9
|
4.1
|
217.3
|
1.0
|
|
HB3
|
I:CYS32
|
4.1
|
220.7
|
1.0
|
|
N
|
I:CYS10
|
4.1
|
216.8
|
1.0
|
|
H
|
I:CYS32
|
4.1
|
220.7
|
1.0
|
|
C
|
I:CYS32
|
4.2
|
220.7
|
1.0
|
|
CA
|
I:CYS10
|
4.2
|
216.8
|
1.0
|
|
HB
|
I:THR31
|
4.3
|
212.0
|
1.0
|
|
OG1
|
I:THR31
|
4.3
|
212.0
|
1.0
|
|
N
|
I:SER33
|
4.4
|
221.2
|
1.0
|
|
CA
|
I:THR31
|
4.4
|
212.0
|
1.0
|
|
H
|
I:ASP9
|
4.5
|
217.3
|
1.0
|
|
CB
|
I:THR31
|
4.6
|
212.0
|
1.0
|
|
C
|
I:ASP9
|
4.6
|
217.3
|
1.0
|
|
OD2
|
I:ASP9
|
4.6
|
217.3
|
1.0
|
|
HB3
|
I:CYS29
|
4.6
|
217.9
|
1.0
|
|
HG1
|
I:THR31
|
4.7
|
212.0
|
1.0
|
|
HA
|
I:CYS10
|
4.8
|
216.8
|
1.0
|
|
HG
|
I:CYS32
|
4.8
|
220.7
|
1.0
|
|
HD22
|
I:ASN12
|
4.8
|
211.3
|
1.0
|
|
CA
|
I:CYS7
|
4.9
|
216.8
|
1.0
|
|
HA
|
I:THR31
|
4.9
|
212.0
|
1.0
|
|
HB2
|
I:ASN12
|
5.0
|
211.3
|
1.0
|
|
Zinc binding site 6 out
of 8 in 8tug
Go back to
Zinc Binding Sites List in 8tug
Zinc binding site 6 out
of 8 in the Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State)
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 6 of Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
I:Zn202
b:223.4
occ:1.00
|
HG
|
I:CYS75
|
1.2
|
195.3
|
1.0
|
|
HB2
|
I:CYS78
|
2.2
|
196.9
|
1.0
|
|
SG
|
I:CYS106
|
2.3
|
191.2
|
1.0
|
|
SG
|
I:CYS103
|
2.3
|
188.4
|
1.0
|
|
SG
|
I:CYS78
|
2.3
|
196.9
|
1.0
|
|
SG
|
I:CYS75
|
2.3
|
195.3
|
1.0
|
|
CB
|
I:CYS78
|
2.7
|
196.9
|
1.0
|
|
HG
|
I:SER105
|
3.0
|
191.4
|
1.0
|
|
HB3
|
I:CYS103
|
3.1
|
188.4
|
1.0
|
|
H
|
I:CYS78
|
3.1
|
196.9
|
1.0
|
|
HB2
|
I:CYS75
|
3.1
|
195.3
|
1.0
|
|
OG
|
I:SER105
|
3.1
|
191.4
|
1.0
|
|
CB
|
I:CYS75
|
3.2
|
195.3
|
1.0
|
|
CB
|
I:CYS103
|
3.3
|
188.4
|
1.0
|
|
HB3
|
I:CYS75
|
3.3
|
195.3
|
1.0
|
|
HB3
|
I:CYS78
|
3.4
|
196.9
|
1.0
|
|
H
|
I:CYS106
|
3.5
|
191.2
|
1.0
|
|
HB3
|
I:CYS106
|
3.5
|
191.2
|
1.0
|
|
CB
|
I:CYS106
|
3.6
|
191.2
|
1.0
|
|
HB2
|
I:CYS103
|
3.6
|
188.4
|
1.0
|
|
HB3
|
I:HIS108
|
3.6
|
185.7
|
1.0
|
|
N
|
I:CYS78
|
3.7
|
196.9
|
1.0
|
|
HG2
|
I:LYS77
|
3.7
|
193.0
|
1.0
|
|
CA
|
I:CYS78
|
3.8
|
196.9
|
1.0
|
|
N
|
I:CYS106
|
3.9
|
191.2
|
1.0
|
|
HG3
|
I:LYS77
|
4.0
|
193.0
|
1.0
|
|
CG
|
I:LYS77
|
4.3
|
193.0
|
1.0
|
|
HB2
|
I:CYS106
|
4.3
|
191.2
|
1.0
|
|
CA
|
I:CYS106
|
4.3
|
191.2
|
1.0
|
|
HA
|
I:CYS78
|
4.4
|
196.9
|
1.0
|
|
H
|
I:HIS108
|
4.4
|
185.7
|
1.0
|
|
HB3
|
I:SER80
|
4.4
|
190.3
|
1.0
|
|
HB2
|
I:HIS108
|
4.4
|
185.7
|
1.0
|
|
CB
|
I:HIS108
|
4.4
|
185.7
|
1.0
|
|
CB
|
I:SER105
|
4.5
|
191.4
|
1.0
|
|
H
|
I:LYS77
|
4.5
|
193.0
|
1.0
|
|
HD2
|
I:LYS77
|
4.6
|
193.0
|
1.0
|
|
CA
|
I:CYS103
|
4.6
|
188.4
|
1.0
|
|
O
|
I:CYS103
|
4.7
|
188.4
|
1.0
|
|
CA
|
I:CYS75
|
4.7
|
195.3
|
1.0
|
|
C
|
I:SER105
|
4.8
|
191.4
|
1.0
|
|
H
|
I:SER80
|
4.8
|
190.3
|
1.0
|
|
H
|
I:HIS79
|
4.8
|
194.1
|
1.0
|
|
C
|
I:CYS103
|
4.9
|
188.4
|
1.0
|
|
H
|
I:SER105
|
4.9
|
191.4
|
1.0
|
|
C
|
I:CYS78
|
4.9
|
196.9
|
1.0
|
|
HB2
|
I:SER105
|
4.9
|
191.4
|
1.0
|
|
HA
|
I:CYS75
|
4.9
|
195.3
|
1.0
|
|
HD2
|
I:PRO76
|
4.9
|
191.2
|
1.0
|
|
HZ3
|
I:LYS77
|
4.9
|
193.0
|
1.0
|
|
C
|
I:LYS77
|
4.9
|
193.0
|
1.0
|
|
Zinc binding site 7 out
of 8 in 8tug
Go back to
Zinc Binding Sites List in 8tug
Zinc binding site 7 out
of 8 in the Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State)
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 7 of Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
J:Zn101
b:118.9
occ:1.00
|
HB3
|
J:CYS46
|
1.9
|
91.9
|
1.0
|
|
HB2
|
J:CYS10
|
2.2
|
88.1
|
1.0
|
|
SG
|
J:CYS45
|
2.3
|
88.3
|
1.0
|
|
SG
|
J:CYS7
|
2.3
|
86.8
|
1.0
|
|
SG
|
J:CYS10
|
2.3
|
88.1
|
1.0
|
|
CB
|
J:CYS46
|
2.6
|
91.9
|
1.0
|
|
CB
|
J:CYS10
|
2.6
|
88.1
|
1.0
|
|
N
|
J:CYS46
|
2.8
|
91.9
|
1.0
|
|
HB2
|
J:CYS7
|
2.8
|
86.8
|
1.0
|
|
H
|
J:CYS46
|
2.8
|
91.9
|
1.0
|
|
CB
|
J:CYS7
|
2.9
|
86.8
|
1.0
|
|
HB3
|
J:CYS7
|
2.9
|
86.8
|
1.0
|
|
HA
|
J:CYS46
|
3.0
|
91.9
|
1.0
|
|
CA
|
J:CYS46
|
3.0
|
91.9
|
1.0
|
|
HG
|
J:CYS46
|
3.1
|
91.9
|
1.0
|
|
HB3
|
J:CYS10
|
3.2
|
88.1
|
1.0
|
|
HH21
|
J:ARG43
|
3.2
|
89.6
|
1.0
|
|
C
|
J:CYS45
|
3.4
|
88.3
|
1.0
|
|
H
|
J:CYS10
|
3.4
|
88.1
|
1.0
|
|
SG
|
J:CYS46
|
3.4
|
91.9
|
1.0
|
|
HB2
|
J:CYS46
|
3.4
|
91.9
|
1.0
|
|
CB
|
J:CYS45
|
3.6
|
88.3
|
1.0
|
|
HB3
|
J:LYS12
|
3.7
|
90.3
|
1.0
|
|
HB2
|
J:CYS45
|
3.8
|
88.3
|
1.0
|
|
HE
|
J:ARG43
|
3.8
|
89.6
|
1.0
|
|
O
|
J:CYS45
|
3.9
|
88.3
|
1.0
|
|
CA
|
J:CYS10
|
3.9
|
88.1
|
1.0
|
|
NH2
|
J:ARG43
|
4.0
|
89.6
|
1.0
|
|
N
|
J:CYS10
|
4.0
|
88.1
|
1.0
|
|
CA
|
J:CYS45
|
4.1
|
88.3
|
1.0
|
|
H
|
J:LYS12
|
4.1
|
90.3
|
1.0
|
|
HB2
|
J:ARG43
|
4.3
|
89.6
|
1.0
|
|
CA
|
J:CYS7
|
4.4
|
86.8
|
1.0
|
|
HB3
|
J:CYS45
|
4.4
|
88.3
|
1.0
|
|
HH22
|
J:ARG43
|
4.5
|
89.6
|
1.0
|
|
H
|
J:GLY11
|
4.5
|
84.7
|
1.0
|
|
C
|
J:CYS46
|
4.5
|
91.9
|
1.0
|
|
NE
|
J:ARG43
|
4.5
|
89.6
|
1.0
|
|
HA
|
J:CYS10
|
4.5
|
88.1
|
1.0
|
|
CB
|
J:LYS12
|
4.5
|
90.3
|
1.0
|
|
HB2
|
J:LYS12
|
4.6
|
90.3
|
1.0
|
|
HD3
|
J:LYS12
|
4.6
|
90.3
|
1.0
|
|
HG3
|
J:MET49
|
4.7
|
86.6
|
1.0
|
|
CZ
|
J:ARG43
|
4.7
|
89.6
|
1.0
|
|
HG2
|
J:MET49
|
4.7
|
86.6
|
1.0
|
|
HA
|
J:CYS7
|
4.7
|
86.8
|
1.0
|
|
OG
|
J:SER9
|
4.8
|
83.7
|
1.0
|
|
C
|
J:CYS10
|
4.8
|
88.1
|
1.0
|
|
N
|
J:CYS45
|
4.8
|
88.3
|
1.0
|
|
N
|
J:GLY11
|
4.8
|
84.7
|
1.0
|
|
H
|
J:CYS45
|
4.8
|
88.3
|
1.0
|
|
HA
|
J:CYS45
|
4.9
|
88.3
|
1.0
|
|
HG11
|
J:VAL14
|
4.9
|
89.2
|
1.0
|
|
N
|
J:LYS12
|
4.9
|
90.3
|
1.0
|
|
Zinc binding site 8 out
of 8 in 8tug
Go back to
Zinc Binding Sites List in 8tug
Zinc binding site 8 out
of 8 in the Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State)
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 8 of Cryo-Em Structure of Cpd-Stalled Pol II in Complex with RAD26 (Engaged State) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
L:Zn101
b:193.0
occ:1.00
|
HG
|
L:CYS48
|
2.2
|
149.0
|
1.0
|
|
HB2
|
L:CYS51
|
2.3
|
152.1
|
1.0
|
|
SG
|
L:CYS34
|
2.3
|
152.9
|
1.0
|
|
SG
|
L:CYS31
|
2.3
|
149.6
|
1.0
|
|
SG
|
L:CYS51
|
2.3
|
152.1
|
1.0
|
|
O
|
L:ALA32
|
2.4
|
145.2
|
1.0
|
|
CB
|
L:CYS51
|
2.7
|
152.1
|
1.0
|
|
HB2
|
L:GLU33
|
3.1
|
146.0
|
1.0
|
|
HB3
|
L:CYS51
|
3.2
|
152.1
|
1.0
|
|
HB3
|
L:CYS34
|
3.3
|
152.9
|
1.0
|
|
SG
|
L:CYS48
|
3.4
|
149.0
|
1.0
|
|
CB
|
L:CYS34
|
3.4
|
152.9
|
1.0
|
|
OE1
|
L:GLU33
|
3.6
|
146.0
|
1.0
|
|
C
|
L:ALA32
|
3.6
|
145.2
|
1.0
|
|
N
|
L:CYS34
|
3.8
|
152.9
|
1.0
|
|
H
|
L:CYS34
|
3.9
|
152.9
|
1.0
|
|
C
|
L:GLU33
|
4.0
|
146.0
|
1.0
|
|
CB
|
L:GLU33
|
4.0
|
146.0
|
1.0
|
|
CA
|
L:CYS51
|
4.1
|
152.1
|
1.0
|
|
H
|
L:CYS51
|
4.1
|
152.1
|
1.0
|
|
CB
|
L:CYS31
|
4.1
|
149.6
|
1.0
|
|
HB2
|
L:CYS34
|
4.2
|
152.9
|
1.0
|
|
HB2
|
L:HIS53
|
4.2
|
146.9
|
1.0
|
|
CA
|
L:CYS34
|
4.2
|
152.9
|
1.0
|
|
N
|
L:CYS51
|
4.2
|
152.1
|
1.0
|
|
H
|
L:ALA32
|
4.3
|
145.2
|
1.0
|
|
CA
|
L:GLU33
|
4.3
|
146.0
|
1.0
|
|
N
|
L:GLU33
|
4.4
|
146.0
|
1.0
|
|
N
|
L:ALA32
|
4.4
|
145.2
|
1.0
|
|
HB2
|
L:CYS48
|
4.4
|
149.0
|
1.0
|
|
O
|
L:GLU33
|
4.4
|
146.0
|
1.0
|
|
HB3
|
L:CYS48
|
4.4
|
149.0
|
1.0
|
|
CB
|
L:CYS48
|
4.5
|
149.0
|
1.0
|
|
HB3
|
L:CYS31
|
4.5
|
149.6
|
1.0
|
|
HB3
|
L:GLU33
|
4.5
|
146.0
|
1.0
|
|
HB2
|
L:CYS31
|
4.5
|
149.6
|
1.0
|
|
HG
|
L:SER36
|
4.5
|
152.2
|
1.0
|
|
ND1
|
L:HIS53
|
4.6
|
146.9
|
1.0
|
|
HB2
|
L:ASP50
|
4.6
|
154.1
|
1.0
|
|
HA
|
L:CYS51
|
4.6
|
152.1
|
1.0
|
|
CD
|
L:GLU33
|
4.6
|
146.0
|
1.0
|
|
H
|
L:HIS53
|
4.7
|
146.9
|
1.0
|
|
CA
|
L:ALA32
|
4.7
|
145.2
|
1.0
|
|
C
|
L:CYS31
|
4.8
|
149.6
|
1.0
|
|
CA
|
L:CYS31
|
4.9
|
149.6
|
1.0
|
|
C
|
L:CYS51
|
4.9
|
152.1
|
1.0
|
|
HA
|
L:CYS31
|
4.9
|
149.6
|
1.0
|
|
CG
|
L:GLU33
|
5.0
|
146.0
|
1.0
|
|
O
|
L:CYS34
|
5.0
|
152.9
|
1.0
|
|
HA
|
L:CYS34
|
5.0
|
152.9
|
1.0
|
|
Reference:
R.D.Sarsam,
J.Xu,
I.Lahiri,
W.Gong,
Q.Li,
J.Oh,
Z.Zhou,
P.Hou,
J.Chong,
N.Hao,
S.Li,
D.Wang,
A.E.Leschziner.
ELF1 Promotes RAD26'S Interaction with Lesion-Arrested Pol II For Transcription-Coupled Repair. Proc.Natl.Acad.Sci.Usa V. 121 45121 2024.
ISSN: ESSN 1091-6490
PubMed: 38194460
DOI: 10.1073/PNAS.2314245121
Page generated: Thu Oct 31 11:47:11 2024
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