Zinc in PDB 8tgp: Crystal Structure of SIRT2 with Fam-PEG4-H4K16(Myristoyl) Peptide

All present enzymatic activity of Crystal Structure of SIRT2 with Fam-PEG4-H4K16(Myristoyl) Peptide:
2.3.1.286;

The structure of Crystal Structure of SIRT2 with Fam-PEG4-H4K16(Myristoyl) Peptide, PDB code: 8tgp was solved by N.I.Nicely, B.P.Weiser, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.01 / 1.76
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	37.138, 76.995, 56.005, 90, 97.89, 90
R / Rfree (%)	19 / 23

The binding sites of Zinc atom in the Crystal Structure of SIRT2 with Fam-PEG4-H4K16(Myristoyl) Peptide (pdb code 8tgp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of SIRT2 with Fam-PEG4-H4K16(Myristoyl) Peptide, PDB code: 8tgp:

Zinc binding site 1 out of 1 in the Crystal Structure of SIRT2 with Fam-PEG4-H4K16(Myristoyl) Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of SIRT2 with Fam-PEG4-H4K16(Myristoyl) Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:20.8 occ:1.00 SG A:CYS224 2.3 19.0 1.0 SG A:CYS221 2.3 21.8 1.0 SG A:CYS200 2.3 30.2 1.0 SG A:CYS195 2.3 17.2 1.0 CB A:CYS200 3.1 32.8 1.0 CB A:CYS221 3.1 20.6 1.0 CB A:CYS195 3.1 22.4 1.0 CB A:CYS224 3.5 23.0 1.0 N A:CYS224 3.9 24.4 1.0 CA A:CYS224 4.2 21.6 1.0 CB A:HIS202 4.5 28.3 1.0 CB A:ASP223 4.5 32.9 1.0 CA A:CYS200 4.5 33.2 1.0 N A:ARG201 4.5 30.8 1.0 CA A:CYS195 4.6 19.2 1.0 CA A:CYS221 4.6 24.8 1.0 N A:HIS202 4.6 25.4 1.0 C A:ASP223 4.7 28.4 1.0 CB A:SER226 4.7 17.1 1.0 C A:CYS200 4.7 36.5 1.0 C A:CYS224 4.8 22.1 1.0 CB A:SER197 4.8 25.6 1.0 OG A:SER226 4.9 16.8 1.0 N A:GLN225 4.9 20.6 1.0 N A:SER226 4.9 17.6 1.0 CA A:ASP223 5.0 29.4 1.0 N A:ASP223 5.0 29.0 1.0

J.Yang, N.I.Nicely, B.P.Weiser. Effects of Dimerization on the Deacylase Activities of Human SIRT2. Biochemistry V. 62 3383 2023.
ISSN: ISSN 0006-2960
PubMed: 37966275
DOI: 10.1021/ACS.BIOCHEM.3C00381