Zinc in PDB 8r1f: Monomeric E6AP-E6-P53 Ternary Complex
Enzymatic activity of Monomeric E6AP-E6-P53 Ternary Complex
All present enzymatic activity of Monomeric E6AP-E6-P53 Ternary Complex:
2.3.2.26;
Zinc Binding Sites:
The binding sites of Zinc atom in the Monomeric E6AP-E6-P53 Ternary Complex
(pdb code 8r1f). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the
Monomeric E6AP-E6-P53 Ternary Complex, PDB code: 8r1f:
Jump to Zinc binding site number:
1;
2;
3;
Zinc binding site 1 out
of 3 in 8r1f
Go back to
Zinc Binding Sites List in 8r1f
Zinc binding site 1 out
of 3 in the Monomeric E6AP-E6-P53 Ternary Complex
![](/pictures/ZN/pdb/r1/8r1f-ZN-sphere_01.jpg) Mono view
![](/pictures/ZN/pdb/r1/8r1f-ZN-sphere_01_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Monomeric E6AP-E6-P53 Ternary Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn201
b:260.1
occ:1.00
|
SG
|
B:CYS110
|
2.3
|
176.2
|
1.0
|
SG
|
B:CYS113
|
2.3
|
179.1
|
1.0
|
SG
|
B:CYS143
|
2.3
|
194.2
|
1.0
|
SG
|
B:CYS146
|
2.3
|
210.5
|
1.0
|
HB2
|
B:CYS146
|
3.0
|
210.5
|
1.0
|
HB2
|
B:CYS110
|
3.1
|
176.2
|
1.0
|
CB
|
B:CYS110
|
3.2
|
176.2
|
1.0
|
CB
|
B:CYS146
|
3.3
|
210.5
|
1.0
|
HB2
|
B:ASN112
|
3.3
|
175.8
|
1.0
|
H
|
B:CYS113
|
3.3
|
179.1
|
1.0
|
HB3
|
B:CYS110
|
3.4
|
176.2
|
1.0
|
H
|
B:CYS143
|
3.6
|
194.2
|
1.0
|
CB
|
B:CYS113
|
3.6
|
179.1
|
1.0
|
HB3
|
B:CYS113
|
3.7
|
179.1
|
1.0
|
N
|
B:CYS113
|
3.8
|
179.1
|
1.0
|
HB3
|
B:CYS146
|
3.9
|
210.5
|
1.0
|
CB
|
B:CYS143
|
4.0
|
194.2
|
1.0
|
HB3
|
B:CYS143
|
4.1
|
194.2
|
1.0
|
H
|
B:ASN112
|
4.2
|
175.8
|
1.0
|
CA
|
B:CYS113
|
4.2
|
179.1
|
1.0
|
CB
|
B:ASN112
|
4.3
|
175.8
|
1.0
|
N
|
B:CYS143
|
4.4
|
194.2
|
1.0
|
HB2
|
B:CYS113
|
4.4
|
179.1
|
1.0
|
N
|
B:CYS146
|
4.5
|
210.5
|
1.0
|
CA
|
B:CYS146
|
4.5
|
210.5
|
1.0
|
H
|
B:CYS146
|
4.5
|
210.5
|
1.0
|
HB3
|
B:LYS115
|
4.5
|
162.2
|
1.0
|
HB2
|
B:CYS143
|
4.6
|
194.2
|
1.0
|
C
|
B:ASN112
|
4.6
|
175.8
|
1.0
|
CA
|
B:CYS110
|
4.6
|
176.2
|
1.0
|
OD1
|
B:ASN112
|
4.6
|
175.8
|
1.0
|
CA
|
B:CYS143
|
4.7
|
194.2
|
1.0
|
N
|
B:ASN112
|
4.8
|
175.8
|
1.0
|
H
|
B:LYS115
|
4.8
|
162.2
|
1.0
|
HB3
|
B:ASN112
|
4.8
|
175.8
|
1.0
|
CA
|
B:ASN112
|
4.8
|
175.8
|
1.0
|
C
|
B:CYS113
|
4.8
|
179.1
|
1.0
|
HA
|
B:CYS110
|
4.8
|
176.2
|
1.0
|
HA
|
B:CYS146
|
4.8
|
210.5
|
1.0
|
HA
|
B:ARG142
|
4.9
|
190.2
|
1.0
|
C
|
B:SER145
|
4.9
|
201.0
|
1.0
|
H
|
B:GLN114
|
4.9
|
170.9
|
1.0
|
CG
|
B:ASN112
|
5.0
|
175.8
|
1.0
|
|
Zinc binding site 2 out
of 3 in 8r1f
Go back to
Zinc Binding Sites List in 8r1f
Zinc binding site 2 out
of 3 in the Monomeric E6AP-E6-P53 Ternary Complex
![](/pictures/ZN/pdb/r1/8r1f-ZN-sphere_02.jpg) Mono view
![](/pictures/ZN/pdb/r1/8r1f-ZN-sphere_02_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Monomeric E6AP-E6-P53 Ternary Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn202
b:249.9
occ:1.00
|
SG
|
B:CYS37
|
2.3
|
183.2
|
1.0
|
SG
|
B:CYS73
|
2.3
|
173.9
|
1.0
|
SG
|
B:CYS40
|
2.3
|
176.2
|
1.0
|
SG
|
B:CYS70
|
2.3
|
180.6
|
1.0
|
HB2
|
B:CYS73
|
2.8
|
173.9
|
1.0
|
HB3
|
B:CYS37
|
2.9
|
183.2
|
1.0
|
CB
|
B:CYS37
|
3.0
|
183.2
|
1.0
|
CB
|
B:CYS73
|
3.1
|
173.9
|
1.0
|
HB2
|
B:CYS37
|
3.2
|
183.2
|
1.0
|
H
|
B:CYS40
|
3.3
|
176.2
|
1.0
|
H
|
B:CYS70
|
3.4
|
180.6
|
1.0
|
HB3
|
B:CYS73
|
3.7
|
173.9
|
1.0
|
CB
|
B:CYS40
|
3.8
|
176.2
|
1.0
|
HB3
|
B:CYS40
|
3.8
|
176.2
|
1.0
|
HB2
|
B:TYR39
|
3.8
|
175.9
|
1.0
|
H
|
B:CYS73
|
3.8
|
173.9
|
1.0
|
CB
|
B:CYS70
|
3.9
|
180.6
|
1.0
|
HB3
|
B:CYS70
|
4.0
|
180.6
|
1.0
|
HE2
|
B:LYS72
|
4.0
|
179.5
|
1.0
|
N
|
B:CYS40
|
4.1
|
176.2
|
1.0
|
HG3
|
B:LYS72
|
4.1
|
179.5
|
1.0
|
N
|
B:CYS70
|
4.2
|
180.6
|
1.0
|
H
|
B:TYR39
|
4.2
|
175.9
|
1.0
|
HG21
|
B:VAL69
|
4.2
|
174.4
|
1.0
|
HD2
|
B:TYR39
|
4.3
|
175.9
|
1.0
|
CA
|
B:CYS73
|
4.4
|
173.9
|
1.0
|
N
|
B:CYS73
|
4.4
|
173.9
|
1.0
|
HB2
|
B:CYS40
|
4.4
|
176.2
|
1.0
|
CA
|
B:CYS37
|
4.5
|
183.2
|
1.0
|
HB2
|
B:CYS70
|
4.5
|
180.6
|
1.0
|
CA
|
B:CYS40
|
4.5
|
176.2
|
1.0
|
CA
|
B:CYS70
|
4.6
|
180.6
|
1.0
|
HB3
|
B:GLN42
|
4.7
|
187.8
|
1.0
|
HA
|
B:VAL69
|
4.7
|
174.4
|
1.0
|
HA
|
B:CYS73
|
4.7
|
173.9
|
1.0
|
CB
|
B:TYR39
|
4.8
|
175.9
|
1.0
|
HG2
|
B:LYS72
|
4.8
|
179.5
|
1.0
|
C
|
B:CYS37
|
4.8
|
183.2
|
1.0
|
H
|
B:GLN42
|
4.8
|
187.8
|
1.0
|
HZ3
|
B:LYS72
|
4.9
|
179.5
|
1.0
|
CG
|
B:LYS72
|
4.9
|
179.5
|
1.0
|
HG23
|
B:VAL69
|
4.9
|
174.4
|
1.0
|
HA
|
B:CYS37
|
4.9
|
183.2
|
1.0
|
N
|
B:TYR39
|
4.9
|
175.9
|
1.0
|
CE
|
B:LYS72
|
4.9
|
179.5
|
1.0
|
O
|
B:CYS37
|
5.0
|
183.2
|
1.0
|
|
Zinc binding site 3 out
of 3 in 8r1f
Go back to
Zinc Binding Sites List in 8r1f
Zinc binding site 3 out
of 3 in the Monomeric E6AP-E6-P53 Ternary Complex
![](/pictures/ZN/pdb/r1/8r1f-ZN-sphere_03.jpg) Mono view
![](/pictures/ZN/pdb/r1/8r1f-ZN-sphere_03_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Monomeric E6AP-E6-P53 Ternary Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Zn401
b:327.9
occ:1.00
|
ND1
|
C:HIS179
|
2.0
|
241.5
|
1.0
|
HB3
|
C:CYS176
|
2.2
|
246.4
|
1.0
|
SG
|
C:CYS238
|
2.3
|
228.6
|
1.0
|
SG
|
C:CYS242
|
2.3
|
243.6
|
1.0
|
SG
|
C:CYS176
|
2.3
|
246.4
|
1.0
|
HE1
|
C:HIS179
|
2.5
|
241.5
|
1.0
|
CE1
|
C:HIS179
|
2.6
|
241.5
|
1.0
|
CB
|
C:CYS176
|
2.7
|
246.4
|
1.0
|
HB3
|
C:CYS242
|
2.7
|
243.6
|
1.0
|
CB
|
C:CYS242
|
3.0
|
243.6
|
1.0
|
HB2
|
C:CYS242
|
3.2
|
243.6
|
1.0
|
H
|
C:CYS176
|
3.2
|
246.4
|
1.0
|
CG
|
C:HIS179
|
3.3
|
241.5
|
1.0
|
H
|
C:ASN239
|
3.4
|
231.4
|
1.0
|
HB2
|
C:CYS176
|
3.4
|
246.4
|
1.0
|
HB2
|
C:HIS179
|
3.5
|
241.5
|
1.0
|
CA
|
C:CYS176
|
3.7
|
246.4
|
1.0
|
HA
|
C:CYS238
|
3.8
|
228.6
|
1.0
|
N
|
C:CYS176
|
3.8
|
246.4
|
1.0
|
NE2
|
C:HIS179
|
3.8
|
241.5
|
1.0
|
CB
|
C:CYS238
|
3.9
|
228.6
|
1.0
|
CB
|
C:HIS179
|
4.0
|
241.5
|
1.0
|
H
|
C:HIS179
|
4.0
|
241.5
|
1.0
|
N
|
C:ASN239
|
4.1
|
231.4
|
1.0
|
CD2
|
C:HIS179
|
4.2
|
241.5
|
1.0
|
CA
|
C:CYS238
|
4.3
|
228.6
|
1.0
|
O
|
C:CYS176
|
4.3
|
246.4
|
1.0
|
C
|
C:CYS176
|
4.3
|
246.4
|
1.0
|
HB3
|
C:CYS238
|
4.3
|
228.6
|
1.0
|
CA
|
C:CYS242
|
4.4
|
243.6
|
1.0
|
HB2
|
C:CYS238
|
4.5
|
228.6
|
1.0
|
O
|
C:ASN239
|
4.5
|
231.4
|
1.0
|
HE2
|
C:HIS179
|
4.5
|
241.5
|
1.0
|
HA
|
C:CYS176
|
4.5
|
246.4
|
1.0
|
HA
|
C:CYS242
|
4.6
|
243.6
|
1.0
|
HG2
|
C:ARG175
|
4.6
|
233.1
|
1.0
|
HB3
|
C:HIS179
|
4.6
|
241.5
|
1.0
|
C
|
C:CYS238
|
4.7
|
228.6
|
1.0
|
N
|
C:HIS179
|
4.7
|
241.5
|
1.0
|
HB2
|
C:ASN239
|
4.7
|
231.4
|
1.0
|
HB3
|
C:HIS178
|
4.7
|
233.0
|
1.0
|
HA3
|
C:GLY245
|
5.0
|
236.1
|
1.0
|
|
Reference:
C.R.Sandate,
D.Chakraborty,
L.Kater,
G.Kempf,
N.H.Thomae.
Monomeric E6AP-E6-P53 Ternary Complex To Be Published.
Page generated: Thu Dec 28 13:38:04 2023
|