Zinc in PDB 8p4c: Structural Insights Into Human Co-Transcriptional Capping - Structure 3

All present enzymatic activity of Structural Insights Into Human Co-Transcriptional Capping - Structure 3:
2.7.7.50; 2.7.7.6; 3.6.1.74;

The structure of Structural Insights Into Human Co-Transcriptional Capping - Structure 3 also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Zinc atom in the Structural Insights Into Human Co-Transcriptional Capping - Structure 3 (pdb code 8p4c). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Structural Insights Into Human Co-Transcriptional Capping - Structure 3, PDB code: 8p4c:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Structural Insights Into Human Co-Transcriptional Capping - Structure 3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Insights Into Human Co-Transcriptional Capping - Structure 3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2001 b:110.1 occ:1.00 SG A:CYS74 2.3 95.8 1.0 SG A:CYS71 2.3 99.8 1.0 NE2 A:HIS84 2.3 83.0 1.0 CB A:CYS71 2.6 99.8 1.0 CD2 A:HIS84 2.8 83.0 1.0 SG A:CYS81 3.3 92.4 1.0 CB A:CYS81 3.4 92.4 1.0 CE1 A:HIS84 3.6 83.0 1.0 O A:PRO82 3.7 82.6 1.0 O A:CYS74 3.7 95.8 1.0 CB A:CYS74 3.9 95.8 1.0 CG A:HIS84 4.1 83.0 1.0 OG1 A:THR73 4.1 97.2 1.0 CA A:CYS71 4.1 99.8 1.0 N A:CYS74 4.2 95.8 1.0 CA A:CYS74 4.4 95.8 1.0 ND1 A:HIS84 4.4 83.0 1.0 CA A:GLY63 4.4 92.5 1.0 C A:CYS74 4.4 95.8 1.0 O A:GLN62 4.6 87.8 1.0 C A:CYS71 4.7 99.8 1.0 CA A:CYS81 4.8 92.4 1.0 N A:CYS71 4.9 99.8 1.0 C A:PRO82 4.9 82.6 1.0 C A:GLY63 4.9 92.5 1.0 O A:ARG61 5.0 92.8 1.0

Zinc binding site 2 out of 3 in the Structural Insights Into Human Co-Transcriptional Capping - Structure 3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structural Insights Into Human Co-Transcriptional Capping - Structure 3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2002 b:153.2 occ:1.00 SG A:CYS114 2.3 130.9 1.0 SG A:CYS111 2.3 132.7 1.0 CB A:CYS114 3.1 130.9 1.0 CE1 A:TYR187 3.3 139.1 1.0 SG A:CYS184 3.4 140.0 1.0 CD1 A:TYR187 3.4 139.1 1.0 N A:CYS184 3.5 140.0 1.0 CZ A:TYR187 3.9 139.1 1.0 CB A:CYS111 3.9 132.7 1.0 CA A:GLY183 4.0 139.0 1.0 CG A:TYR187 4.1 139.1 1.0 CB A:CYS184 4.2 140.0 1.0 C A:GLY183 4.3 139.0 1.0 CD A:LYS116 4.3 128.9 1.0 CE2 A:TYR187 4.4 139.1 1.0 CA A:CYS184 4.5 140.0 1.0 O A:GLY182 4.5 135.6 1.0 OH A:TYR187 4.5 139.1 1.0 CD2 A:TYR187 4.5 139.1 1.0 CA A:CYS114 4.6 130.9 1.0 O A:PHE112 4.6 125.8 1.0 CB A:LYS116 4.8 128.9 1.0 NZ A:LYS116 4.9 128.9 1.0 CB A:TYR187 4.9 139.1 1.0 N A:GLY185 4.9 140.5 1.0 CG A:LYS116 4.9 128.9 1.0

Zinc binding site 3 out of 3 in the Structural Insights Into Human Co-Transcriptional Capping - Structure 3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structural Insights Into Human Co-Transcriptional Capping - Structure 3 within 5.0Å range: probe atom residue distance (Å) B Occ Y:Zn201 b:123.3 occ:1.00 SG Y:CYS16 2.5 81.2 1.0 SG Y:CYS33 2.5 73.7 1.0 SG Y:CYS19 2.5 84.5 1.0 CB Y:CYS16 3.4 81.2 1.0 N Y:CYS19 3.7 84.5 1.0 CB Y:CYS19 3.7 84.5 1.0 CB Y:CYS33 3.9 73.7 1.0 CB Y:LEU18 4.0 79.2 1.0 CD1 Y:LEU40 4.2 85.1 1.0 CA Y:CYS19 4.2 84.5 1.0 C Y:LEU18 4.6 79.2 1.0 N Y:LEU18 4.6 79.2 1.0 CA Y:LEU18 4.6 79.2 1.0 CD2 Y:LEU18 4.6 79.2 1.0 CG Y:LEU18 4.7 79.2 1.0 CB Y:LEU21 4.7 77.5 1.0 N Y:CYS36 4.8 80.7 1.0 CA Y:CYS16 4.8 81.2 1.0 C Y:CYS19 4.8 84.5 1.0 CB Y:CYS36 4.9 80.7 1.0 N Y:SER20 5.0 78.2 1.0

G.Garg, C.Dienemann, L.Farnung, J.Schwarz, A.Linden, H.Urlaub, P.Cramer. Structural Insights Into Human Co-Transcriptional Capping. Mol.Cell V. 83 2464 2023.
ISSN: ISSN 1097-2765
PubMed: 37369200
DOI: 10.1016/J.MOLCEL.2023.06.002