Zinc in PDB 8ov6: Ternary Structure of Bivalent Glue Degrader Compound 1 Bound to BRD4 and DCAF16:DDB1DELTABPB

Zinc Binding Sites:

The binding sites of Zinc atom in the Ternary Structure of Bivalent Glue Degrader Compound 1 Bound to BRD4 and DCAF16:DDB1DELTABPB (pdb code 8ov6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Ternary Structure of Bivalent Glue Degrader Compound 1 Bound to BRD4 and DCAF16:DDB1DELTABPB, PDB code: 8ov6:

Zinc binding site 1 out of 1 in 8ov6

Go back to Zinc Binding Sites List in 8ov6
Zinc binding site 1 out of 1 in the Ternary Structure of Bivalent Glue Degrader Compound 1 Bound to BRD4 and DCAF16:DDB1DELTABPB


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Ternary Structure of Bivalent Glue Degrader Compound 1 Bound to BRD4 and DCAF16:DDB1DELTABPB within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn301

b:124.2
occ:1.00
SG B:CYS177 2.3 104.7 1.0
SG B:CYS103 2.3 100.0 1.0
SG B:CYS179 2.3 100.9 1.0
SG B:CYS100 2.4 97.0 1.0
HB3 B:CYS100 3.0 97.0 1.0
CB B:CYS100 3.2 97.0 1.0
HB2 B:CYS179 3.3 100.9 1.0
HB2 B:CYS100 3.4 97.0 1.0
HB2 B:CYS177 3.5 104.7 1.0
CB B:CYS179 3.5 100.9 1.0
HB2 B:CYS103 3.6 100.0 1.0
H B:CYS103 3.6 100.0 1.0
CB B:CYS177 3.6 104.7 1.0
CB B:CYS103 3.7 100.0 1.0
H B:CYS179 3.8 100.9 1.0
HB3 B:HIS102 3.8 97.9 1.0
HB2 B:TYR201 4.0 94.1 1.0
HB3 B:CYS179 4.1 100.9 1.0
N B:CYS103 4.2 100.0 1.0
HB3 B:CYS177 4.3 104.7 1.0
HB3 B:CYS103 4.4 100.0 1.0
HA B:CYS177 4.4 104.7 1.0
N B:CYS179 4.5 100.9 1.0
CA B:CYS103 4.6 100.0 1.0
CA B:CYS177 4.6 104.7 1.0
CA B:CYS179 4.6 100.9 1.0
CA B:CYS100 4.7 97.0 1.0
H B:TYR201 4.7 94.1 1.0
CB B:HIS102 4.8 97.9 1.0
H B:CYS178 4.8 106.0 1.0
HD1 B:TYR201 4.8 94.1 1.0
HA B:TYR201 4.8 94.1 1.0
CB B:TYR201 4.9 94.1 1.0
ND1 B:HIS102 4.9 97.9 1.0
HA B:CYS103 4.9 100.0 1.0
HA B:CYS179 4.9 100.9 1.0
H B:HIS102 4.9 97.9 1.0
N B:TYR201 5.0 94.1 1.0

Reference:

O.Hsia, M.Hinterndorfer, A.D.Cowan, K.Iso, I.Ishida, R.Sundaramoorthy, M.A.Nakasone, H.Imrichova, A.Rukvina, K.Husnjak, M.Wegner, A.Correa-Saez, C.Craigon, C.Maniaci, A.Testa, M.Kaulich, I.Dikic, G.E.Winter, A.Ciulli. An Intramolecular Bivalent Degrader Glues An Intrinsic BRD4-DCAF16 Interaction To Be Published.
Page generated: Fri Jul 28 07:22:11 2023

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