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Zinc in PDB 8ou3: Cereblon Isoform 4 in Complex with Novel Benzamide-Type Cereblon Binder 8DProtein crystallography data
The structure of Cereblon Isoform 4 in Complex with Novel Benzamide-Type Cereblon Binder 8D, PDB code: 8ou3
was solved by
C.Heim,
L.Bischof,
S.Maiwald,
M.D.Hartmann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8ou3:
The structure of Cereblon Isoform 4 in Complex with Novel Benzamide-Type Cereblon Binder 8D also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Cereblon Isoform 4 in Complex with Novel Benzamide-Type Cereblon Binder 8D
(pdb code 8ou3). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Cereblon Isoform 4 in Complex with Novel Benzamide-Type Cereblon Binder 8D, PDB code: 8ou3: Jump to Zinc binding site number: 1; 2; 3; Zinc binding site 1 out of 3 in 8ou3Go back to Zinc Binding Sites List in 8ou3
Zinc binding site 1 out
of 3 in the Cereblon Isoform 4 in Complex with Novel Benzamide-Type Cereblon Binder 8D
Mono view Stereo pair view
Zinc binding site 2 out of 3 in 8ou3Go back to Zinc Binding Sites List in 8ou3
Zinc binding site 2 out
of 3 in the Cereblon Isoform 4 in Complex with Novel Benzamide-Type Cereblon Binder 8D
Mono view Stereo pair view
Zinc binding site 3 out of 3 in 8ou3Go back to Zinc Binding Sites List in 8ou3
Zinc binding site 3 out
of 3 in the Cereblon Isoform 4 in Complex with Novel Benzamide-Type Cereblon Binder 8D
Mono view Stereo pair view
Reference:
C.Steinebach,
A.Bricelj,
A.Murgai,
I.Sosic,
L.Bischof,
Y.L.D.Ng,
C.Heim,
S.Maiwald,
M.Proj,
R.Voget,
F.Feller,
J.Kosmrlj,
V.Sapozhnikova,
A.Schmidt,
M.R.Zuleeg,
P.Lemnitzer,
P.Mertins,
F.K.Hansen,
M.Gutschow,
J.Kronke,
M.D.Hartmann.
Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders For the Design of Protacs. J.Med.Chem. 2023.
Page generated: Thu Oct 31 08:57:57 2024
ISSN: ISSN 0022-2623 PubMed: 37902300 DOI: 10.1021/ACS.JMEDCHEM.3C00851 |
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