Zinc in PDB 8og2: Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A

Enzymatic activity of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A

All present enzymatic activity of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A:
2.3.1.48;

Protein crystallography data

The structure of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A, PDB code: 8og2 was solved by A.E.Mechaly, W.Zhang, A.Haouz, M.Green, F.Rodrigues-Lima, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 77.66 / 2.47
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 86.766, 145.69, 155.312, 90, 90, 90
R / Rfree (%) 23.6 / 28.9

Other elements in 8og2:

The structure of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A also contains other interesting chemical elements:

Sodium (Na) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A (pdb code 8og2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A, PDB code: 8og2:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 8og2

Go back to Zinc Binding Sites List in 8og2
Zinc binding site 1 out of 4 in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1802

b:50.3
occ:1.00
 SG A:CYS1200 2.1 59.1 1.0
ND1 A:HIS1291 2.1 45.3 1.0
SG A:CYS1199 2.2 52.1 1.0
SG A:CYS1294 2.5 48.9 1.0
CB A:CYS1199 2.8 58.0 1.0
CG A:HIS1291 3.0 50.8 1.0
N A:CYS1200 3.1 67.5 1.0
CE1 A:HIS1291 3.1 40.4 1.0
CB A:HIS1291 3.3 61.9 1.0
CB A:CYS1294 3.4 50.6 1.0
CB A:CYS1200 3.4 55.0 1.0
C A:CYS1199 3.6 63.0 1.0
CA A:CYS1199 3.8 61.5 1.0
CA A:CYS1200 3.8 49.8 1.0
CD2 A:HIS1291 4.2 39.7 1.0
NE2 A:HIS1291 4.2 38.5 1.0
N A:HIS1291 4.3 39.3 1.0
CA A:HIS1291 4.4 47.2 1.0
N A:CYS1199 4.5 63.4 1.0
C A:CYS1200 4.5 36.8 1.0
O A:CYS1199 4.6 52.0 1.0
CH2 A:TRP1151 4.6 37.7 1.0
CE2 A:TYR1204 4.7 48.2 1.0
CA A:CYS1294 4.8 45.0 1.0
NH2 A:ARG1682 4.8 23.2 1.0
O A:CYS1200 4.8 37.7 1.0
CZ2 A:TRP1151 5.0 39.6 1.0

Zinc binding site 2 out of 4 in 8og2

Go back to Zinc Binding Sites List in 8og2
Zinc binding site 2 out of 4 in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1803

b:70.2
occ:1.00
 SG A:CYS1286 2.3 75.6 1.0
SG A:CYS1283 2.4 79.4 1.0
SG A:CYS1308 2.4 74.9 1.0
SG A:CYS1311 2.6 64.3 1.0
CB A:CYS1308 2.6 56.9 1.0
CB A:CYS1286 2.9 57.9 1.0
CB A:CYS1283 3.3 51.1 1.0
CB A:CYS1311 3.4 58.3 1.0
N A:CYS1308 3.5 92.0 1.0
N A:CYS1286 3.5 79.2 1.0
CA A:CYS1308 3.6 74.2 1.0
CA A:CYS1286 3.8 66.7 1.0
C A:CYS1308 4.5 76.4 1.0
N A:CYS1311 4.6 78.1 1.0
CA A:CYS1311 4.6 62.2 1.0
C A:GLU1285 4.7 73.8 1.0
CA A:CYS1283 4.7 59.2 1.0
C A:VAL1307 4.8 81.5 1.0
CG1 A:VAL1307 4.8 61.3 1.0
CG A:ARG1288 4.8 65.9 1.0
CD A:ARG1288 4.9 67.0 1.0

Zinc binding site 3 out of 4 in 8og2

Go back to Zinc Binding Sites List in 8og2
Zinc binding site 3 out of 4 in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1804

b:177.0
occ:1.00
 SG A:CYS1710 1.9 268.0 1.0
CB A:CYS1729 2.1 240.7 1.0
SG A:CYS1729 2.3 239.6 1.0
CB A:CYS1710 2.4 221.4 1.0
SG A:CYS1707 2.5 144.0 1.0
CA A:CYS1729 3.4 203.3 1.0
N A:CYS1729 3.7 188.3 1.0
ND2 A:ASN1731 3.8 99.4 1.0
CA A:CYS1710 3.8 183.5 1.0
ND1 A:HIS1712 4.0 99.0 1.0
CB A:CYS1707 4.1 127.3 1.0
N A:CYS1710 4.2 178.3 1.0
CB A:HIS1712 4.4 107.6 1.0
CB A:ASN1731 4.5 138.9 1.0
C A:CYS1729 4.5 183.2 1.0
CG A:ASN1731 4.6 123.0 1.0
CG A:HIS1712 4.7 97.4 1.0
CG A:LEU1728 4.7 132.8 1.0
CD2 A:LEU1728 4.8 133.4 1.0
C A:CYS1710 4.8 151.8 1.0
O A:CYS1729 4.9 178.0 1.0
C A:LEU1728 5.0 166.0 1.0

Zinc binding site 4 out of 4 in 8og2

Go back to Zinc Binding Sites List in 8og2
Zinc binding site 4 out of 4 in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1805

b:301.2
occ:1.00
 ND1 A:HIS1740 2.3 154.2 1.0
CD2 A:HIS1738 2.4 257.8 1.0
CE1 A:TYR1726 2.4 111.4 1.0
CE1 A:HIS1740 2.7 155.2 1.0
CZ A:TYR1726 2.8 119.5 1.0
NE2 A:HIS1738 2.9 271.5 1.0
CD1 A:TYR1726 3.1 109.9 1.0
OH A:TYR1726 3.2 133.6 1.0
SG A:CYS1720 3.6 178.4 1.0
CG A:HIS1740 3.6 156.8 1.0
CG A:HIS1738 3.6 253.0 1.0
CE2 A:TYR1726 3.7 115.5 1.0
SG A:CYS1723 3.9 139.3 1.0
CG A:TYR1726 3.9 115.0 1.0
NE2 A:HIS1740 4.0 155.8 1.0
CD2 A:TYR1726 4.2 109.7 1.0
CE1 A:HIS1738 4.2 276.8 1.0
CB A:HIS1740 4.3 165.6 1.0
CB A:HIS1738 4.4 198.6 1.0
CD2 A:HIS1740 4.4 153.8 1.0
ND1 A:HIS1738 4.5 270.4 1.0
N A:HIS1740 5.0 173.2 1.0

Reference:

A.E.Mechaly, W.Zhang, A.Haouz, M.Green, F.Rodrigues-Lima. Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A To Be Published.
Page generated: Thu Oct 31 08:46:43 2024

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