Zinc in PDB 8og2: Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A
Enzymatic activity of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A
All present enzymatic activity of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A:
2.3.1.48;
Protein crystallography data
The structure of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A, PDB code: 8og2
was solved by
A.E.Mechaly,
W.Zhang,
A.Haouz,
M.Green,
F.Rodrigues-Lima,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
77.66 /
2.47
|
Space group
|
I 2 2 2
|
Cell size a, b, c (Å), α, β, γ (°)
|
86.766,
145.69,
155.312,
90,
90,
90
|
R / Rfree (%)
|
23.6 /
28.9
|
Other elements in 8og2:
The structure of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A
(pdb code 8og2). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the
Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A, PDB code: 8og2:
Jump to Zinc binding site number:
1;
2;
3;
4;
Zinc binding site 1 out
of 4 in 8og2
Go back to
Zinc Binding Sites List in 8og2
Zinc binding site 1 out
of 4 in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1802
b:50.3
occ:1.00
|
SG
|
A:CYS1200
|
2.1
|
59.1
|
1.0
|
ND1
|
A:HIS1291
|
2.1
|
45.3
|
1.0
|
SG
|
A:CYS1199
|
2.2
|
52.1
|
1.0
|
SG
|
A:CYS1294
|
2.5
|
48.9
|
1.0
|
CB
|
A:CYS1199
|
2.8
|
58.0
|
1.0
|
CG
|
A:HIS1291
|
3.0
|
50.8
|
1.0
|
N
|
A:CYS1200
|
3.1
|
67.5
|
1.0
|
CE1
|
A:HIS1291
|
3.1
|
40.4
|
1.0
|
CB
|
A:HIS1291
|
3.3
|
61.9
|
1.0
|
CB
|
A:CYS1294
|
3.4
|
50.6
|
1.0
|
CB
|
A:CYS1200
|
3.4
|
55.0
|
1.0
|
C
|
A:CYS1199
|
3.6
|
63.0
|
1.0
|
CA
|
A:CYS1199
|
3.8
|
61.5
|
1.0
|
CA
|
A:CYS1200
|
3.8
|
49.8
|
1.0
|
CD2
|
A:HIS1291
|
4.2
|
39.7
|
1.0
|
NE2
|
A:HIS1291
|
4.2
|
38.5
|
1.0
|
N
|
A:HIS1291
|
4.3
|
39.3
|
1.0
|
CA
|
A:HIS1291
|
4.4
|
47.2
|
1.0
|
N
|
A:CYS1199
|
4.5
|
63.4
|
1.0
|
C
|
A:CYS1200
|
4.5
|
36.8
|
1.0
|
O
|
A:CYS1199
|
4.6
|
52.0
|
1.0
|
CH2
|
A:TRP1151
|
4.6
|
37.7
|
1.0
|
CE2
|
A:TYR1204
|
4.7
|
48.2
|
1.0
|
CA
|
A:CYS1294
|
4.8
|
45.0
|
1.0
|
NH2
|
A:ARG1682
|
4.8
|
23.2
|
1.0
|
O
|
A:CYS1200
|
4.8
|
37.7
|
1.0
|
CZ2
|
A:TRP1151
|
5.0
|
39.6
|
1.0
|
|
Zinc binding site 2 out
of 4 in 8og2
Go back to
Zinc Binding Sites List in 8og2
Zinc binding site 2 out
of 4 in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1803
b:70.2
occ:1.00
|
SG
|
A:CYS1286
|
2.3
|
75.6
|
1.0
|
SG
|
A:CYS1283
|
2.4
|
79.4
|
1.0
|
SG
|
A:CYS1308
|
2.4
|
74.9
|
1.0
|
SG
|
A:CYS1311
|
2.6
|
64.3
|
1.0
|
CB
|
A:CYS1308
|
2.6
|
56.9
|
1.0
|
CB
|
A:CYS1286
|
2.9
|
57.9
|
1.0
|
CB
|
A:CYS1283
|
3.3
|
51.1
|
1.0
|
CB
|
A:CYS1311
|
3.4
|
58.3
|
1.0
|
N
|
A:CYS1308
|
3.5
|
92.0
|
1.0
|
N
|
A:CYS1286
|
3.5
|
79.2
|
1.0
|
CA
|
A:CYS1308
|
3.6
|
74.2
|
1.0
|
CA
|
A:CYS1286
|
3.8
|
66.7
|
1.0
|
C
|
A:CYS1308
|
4.5
|
76.4
|
1.0
|
N
|
A:CYS1311
|
4.6
|
78.1
|
1.0
|
CA
|
A:CYS1311
|
4.6
|
62.2
|
1.0
|
C
|
A:GLU1285
|
4.7
|
73.8
|
1.0
|
CA
|
A:CYS1283
|
4.7
|
59.2
|
1.0
|
C
|
A:VAL1307
|
4.8
|
81.5
|
1.0
|
CG1
|
A:VAL1307
|
4.8
|
61.3
|
1.0
|
CG
|
A:ARG1288
|
4.8
|
65.9
|
1.0
|
CD
|
A:ARG1288
|
4.9
|
67.0
|
1.0
|
|
Zinc binding site 3 out
of 4 in 8og2
Go back to
Zinc Binding Sites List in 8og2
Zinc binding site 3 out
of 4 in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1804
b:177.0
occ:1.00
|
SG
|
A:CYS1710
|
1.9
|
268.0
|
1.0
|
CB
|
A:CYS1729
|
2.1
|
240.7
|
1.0
|
SG
|
A:CYS1729
|
2.3
|
239.6
|
1.0
|
CB
|
A:CYS1710
|
2.4
|
221.4
|
1.0
|
SG
|
A:CYS1707
|
2.5
|
144.0
|
1.0
|
CA
|
A:CYS1729
|
3.4
|
203.3
|
1.0
|
N
|
A:CYS1729
|
3.7
|
188.3
|
1.0
|
ND2
|
A:ASN1731
|
3.8
|
99.4
|
1.0
|
CA
|
A:CYS1710
|
3.8
|
183.5
|
1.0
|
ND1
|
A:HIS1712
|
4.0
|
99.0
|
1.0
|
CB
|
A:CYS1707
|
4.1
|
127.3
|
1.0
|
N
|
A:CYS1710
|
4.2
|
178.3
|
1.0
|
CB
|
A:HIS1712
|
4.4
|
107.6
|
1.0
|
CB
|
A:ASN1731
|
4.5
|
138.9
|
1.0
|
C
|
A:CYS1729
|
4.5
|
183.2
|
1.0
|
CG
|
A:ASN1731
|
4.6
|
123.0
|
1.0
|
CG
|
A:HIS1712
|
4.7
|
97.4
|
1.0
|
CG
|
A:LEU1728
|
4.7
|
132.8
|
1.0
|
CD2
|
A:LEU1728
|
4.8
|
133.4
|
1.0
|
C
|
A:CYS1710
|
4.8
|
151.8
|
1.0
|
O
|
A:CYS1729
|
4.9
|
178.0
|
1.0
|
C
|
A:LEU1728
|
5.0
|
166.0
|
1.0
|
|
Zinc binding site 4 out
of 4 in 8og2
Go back to
Zinc Binding Sites List in 8og2
Zinc binding site 4 out
of 4 in the Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1805
b:301.2
occ:1.00
|
ND1
|
A:HIS1740
|
2.3
|
154.2
|
1.0
|
CD2
|
A:HIS1738
|
2.4
|
257.8
|
1.0
|
CE1
|
A:TYR1726
|
2.4
|
111.4
|
1.0
|
CE1
|
A:HIS1740
|
2.7
|
155.2
|
1.0
|
CZ
|
A:TYR1726
|
2.8
|
119.5
|
1.0
|
NE2
|
A:HIS1738
|
2.9
|
271.5
|
1.0
|
CD1
|
A:TYR1726
|
3.1
|
109.9
|
1.0
|
OH
|
A:TYR1726
|
3.2
|
133.6
|
1.0
|
SG
|
A:CYS1720
|
3.6
|
178.4
|
1.0
|
CG
|
A:HIS1740
|
3.6
|
156.8
|
1.0
|
CG
|
A:HIS1738
|
3.6
|
253.0
|
1.0
|
CE2
|
A:TYR1726
|
3.7
|
115.5
|
1.0
|
SG
|
A:CYS1723
|
3.9
|
139.3
|
1.0
|
CG
|
A:TYR1726
|
3.9
|
115.0
|
1.0
|
NE2
|
A:HIS1740
|
4.0
|
155.8
|
1.0
|
CD2
|
A:TYR1726
|
4.2
|
109.7
|
1.0
|
CE1
|
A:HIS1738
|
4.2
|
276.8
|
1.0
|
CB
|
A:HIS1740
|
4.3
|
165.6
|
1.0
|
CB
|
A:HIS1738
|
4.4
|
198.6
|
1.0
|
CD2
|
A:HIS1740
|
4.4
|
153.8
|
1.0
|
ND1
|
A:HIS1738
|
4.5
|
270.4
|
1.0
|
N
|
A:HIS1740
|
5.0
|
173.2
|
1.0
|
|
Reference:
A.E.Mechaly,
W.Zhang,
A.Haouz,
M.Green,
F.Rodrigues-Lima.
Crystal Structure of Crebbp Histone Acetyltransferase Domain in Complex with Coenzyme A To Be Published.
Page generated: Thu Oct 31 08:46:43 2024
|