Zinc in PDB 8oev: Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3)
Enzymatic activity of Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3)
All present enzymatic activity of Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3):
2.7.7.6;
Other elements in 8oev:
The structure of Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3) also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3)
(pdb code 8oev). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 8 binding sites of Zinc where determined in the
Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3), PDB code: 8oev:
Jump to Zinc binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Zinc binding site 1 out
of 8 in 8oev
Go back to
Zinc Binding Sites List in 8oev
Zinc binding site 1 out
of 8 in the Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3)
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn2002
b:69.9
occ:1.00
|
NE2
|
A:HIS84
|
2.1
|
40.4
|
1.0
|
SG
|
A:CYS74
|
2.3
|
53.4
|
1.0
|
SG
|
A:CYS81
|
2.3
|
43.1
|
1.0
|
SG
|
A:CYS71
|
2.3
|
55.6
|
1.0
|
CD2
|
A:HIS84
|
2.6
|
40.4
|
1.0
|
CB
|
A:CYS71
|
2.9
|
55.6
|
1.0
|
CE1
|
A:HIS84
|
3.2
|
40.4
|
1.0
|
CB
|
A:CYS81
|
3.6
|
43.1
|
1.0
|
CG
|
A:HIS84
|
3.9
|
40.4
|
1.0
|
CB
|
A:CYS74
|
3.9
|
53.4
|
1.0
|
N
|
A:CYS74
|
3.9
|
53.4
|
1.0
|
ND1
|
A:HIS84
|
4.1
|
40.4
|
1.0
|
O
|
A:CYS74
|
4.2
|
53.4
|
1.0
|
CA
|
A:CYS81
|
4.3
|
43.1
|
1.0
|
CA
|
A:CYS74
|
4.4
|
53.4
|
1.0
|
CA
|
A:CYS71
|
4.4
|
55.6
|
1.0
|
CA
|
A:GLY63
|
4.5
|
48.1
|
1.0
|
CB
|
A:THR73
|
4.6
|
50.2
|
1.0
|
N
|
A:GLY83
|
4.6
|
37.5
|
1.0
|
CD
|
A:PRO82
|
4.7
|
37.6
|
1.0
|
C
|
A:CYS74
|
4.7
|
53.4
|
1.0
|
O
|
A:GLN62
|
4.7
|
42.7
|
1.0
|
C
|
A:CYS81
|
4.9
|
43.1
|
1.0
|
C
|
A:THR73
|
4.9
|
50.2
|
1.0
|
N
|
A:THR73
|
4.9
|
50.2
|
1.0
|
CA
|
A:GLY83
|
4.9
|
37.5
|
1.0
|
N
|
A:PRO82
|
4.9
|
37.6
|
1.0
|
|
Zinc binding site 2 out
of 8 in 8oev
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Zinc Binding Sites List in 8oev
Zinc binding site 2 out
of 8 in the Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3)
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn2003
b:122.3
occ:1.00
|
CB
|
A:CYS184
|
2.2
|
87.2
|
1.0
|
SG
|
A:CYS111
|
2.3
|
79.4
|
1.0
|
SG
|
A:CYS114
|
2.3
|
79.0
|
1.0
|
SG
|
A:CYS154
|
2.3
|
89.8
|
1.0
|
SG
|
A:CYS184
|
2.3
|
87.2
|
1.0
|
CB
|
A:CYS111
|
3.1
|
79.4
|
1.0
|
CB
|
A:CYS114
|
3.4
|
79.0
|
1.0
|
N
|
A:CYS114
|
3.7
|
79.0
|
1.0
|
CA
|
A:CYS184
|
3.7
|
87.2
|
1.0
|
CB
|
A:CYS154
|
4.1
|
89.8
|
1.0
|
NE2
|
A:GLN188
|
4.1
|
84.3
|
1.0
|
CA
|
A:CYS114
|
4.1
|
79.0
|
1.0
|
N
|
A:CYS184
|
4.3
|
87.2
|
1.0
|
C
|
A:CYS184
|
4.5
|
87.2
|
1.0
|
CA
|
A:CYS111
|
4.6
|
79.4
|
1.0
|
CB
|
A:PHE113
|
4.7
|
78.7
|
1.0
|
C
|
A:PHE113
|
4.8
|
78.7
|
1.0
|
C
|
A:CYS114
|
4.9
|
79.0
|
1.0
|
N
|
A:PHE113
|
4.9
|
78.7
|
1.0
|
CD2
|
A:PHE113
|
5.0
|
78.7
|
1.0
|
|
Zinc binding site 3 out
of 8 in 8oev
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Zinc Binding Sites List in 8oev
Zinc binding site 3 out
of 8 in the Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3)
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn2000
b:97.5
occ:1.00
|
SG
|
B:CYS1199
|
2.3
|
50.8
|
1.0
|
SG
|
B:CYS1196
|
2.3
|
51.1
|
1.0
|
SG
|
B:CYS1214
|
2.3
|
61.3
|
1.0
|
SG
|
B:CYS1217
|
2.3
|
68.3
|
1.0
|
CB
|
B:CYS1196
|
2.7
|
51.1
|
1.0
|
CB
|
B:CYS1217
|
3.1
|
68.3
|
1.0
|
CB
|
B:CYS1199
|
3.2
|
50.8
|
1.0
|
CB
|
B:CYS1214
|
3.7
|
61.3
|
1.0
|
N
|
B:CYS1199
|
3.8
|
50.8
|
1.0
|
CA
|
B:CYS1199
|
4.1
|
50.8
|
1.0
|
CA
|
B:CYS1196
|
4.2
|
51.1
|
1.0
|
CA
|
B:CYS1217
|
4.4
|
68.3
|
1.0
|
N
|
B:CYS1217
|
4.4
|
68.3
|
1.0
|
CB
|
B:LEU1198
|
4.7
|
52.6
|
1.0
|
O
|
B:ARG1215
|
4.8
|
60.0
|
1.0
|
ND2
|
B:ASN1219
|
4.8
|
64.8
|
1.0
|
C
|
B:LEU1198
|
4.8
|
52.6
|
1.0
|
CB
|
B:ASN1219
|
4.9
|
64.8
|
1.0
|
C
|
B:CYS1199
|
4.9
|
50.8
|
1.0
|
C
|
B:GLY1216
|
4.9
|
63.1
|
1.0
|
C
|
B:CYS1196
|
4.9
|
51.1
|
1.0
|
N
|
B:GLY1200
|
5.0
|
44.0
|
1.0
|
|
Zinc binding site 4 out
of 8 in 8oev
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Zinc Binding Sites List in 8oev
Zinc binding site 4 out
of 8 in the Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3)
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Zn301
b:85.0
occ:1.00
|
SG
|
C:CYS94
|
2.3
|
33.2
|
1.0
|
SG
|
C:CYS88
|
2.3
|
42.4
|
1.0
|
SG
|
C:CYS90
|
2.3
|
53.5
|
1.0
|
SG
|
C:CYS97
|
2.3
|
29.0
|
1.0
|
CB
|
C:CYS97
|
3.2
|
29.0
|
1.0
|
CB
|
C:CYS90
|
3.2
|
53.5
|
1.0
|
CB
|
C:CYS88
|
3.2
|
42.4
|
1.0
|
CB
|
C:CYS94
|
3.5
|
33.2
|
1.0
|
N
|
C:CYS94
|
3.7
|
33.2
|
1.0
|
N
|
C:CYS97
|
4.0
|
29.0
|
1.0
|
CA
|
C:CYS94
|
4.1
|
33.2
|
1.0
|
N
|
C:CYS90
|
4.2
|
53.5
|
1.0
|
CA
|
C:CYS97
|
4.2
|
29.0
|
1.0
|
CA
|
C:CYS90
|
4.3
|
53.5
|
1.0
|
C
|
C:PHE93
|
4.3
|
34.3
|
1.0
|
O
|
C:CYS94
|
4.3
|
33.2
|
1.0
|
C
|
C:CYS94
|
4.5
|
33.2
|
1.0
|
CA
|
C:CYS88
|
4.6
|
42.4
|
1.0
|
CA
|
C:PHE93
|
4.6
|
34.3
|
1.0
|
C
|
C:GLU96
|
4.7
|
31.0
|
1.0
|
C
|
C:CYS88
|
4.8
|
42.4
|
1.0
|
CB
|
C:GLU96
|
5.0
|
31.0
|
1.0
|
C
|
C:CYS97
|
5.0
|
29.0
|
1.0
|
N
|
C:THR89
|
5.0
|
51.1
|
1.0
|
|
Zinc binding site 5 out
of 8 in 8oev
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Zinc Binding Sites List in 8oev
Zinc binding site 5 out
of 8 in the Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3)
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 5 of Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
I:Zn201
b:89.6
occ:1.00
|
SG
|
I:CYS119
|
2.3
|
54.0
|
1.0
|
SG
|
I:CYS89
|
2.3
|
61.1
|
1.0
|
SG
|
I:CYS86
|
2.3
|
59.2
|
1.0
|
SG
|
I:CYS114
|
2.3
|
49.3
|
1.0
|
CB
|
I:CYS86
|
3.0
|
59.2
|
1.0
|
CB
|
I:CYS114
|
3.1
|
49.3
|
1.0
|
CB
|
I:CYS119
|
3.4
|
54.0
|
1.0
|
CB
|
I:CYS89
|
3.4
|
61.1
|
1.0
|
N
|
I:CYS89
|
4.0
|
61.1
|
1.0
|
CA
|
I:CYS89
|
4.2
|
61.1
|
1.0
|
CB
|
I:HIS91
|
4.3
|
53.2
|
1.0
|
CB
|
I:HIS121
|
4.4
|
53.0
|
1.0
|
CA
|
I:CYS86
|
4.5
|
59.2
|
1.0
|
CA
|
I:CYS114
|
4.6
|
49.3
|
1.0
|
CB
|
I:ALA116
|
4.7
|
46.2
|
1.0
|
N
|
I:HIS91
|
4.7
|
53.2
|
1.0
|
C
|
I:CYS89
|
4.7
|
61.1
|
1.0
|
N
|
I:GLY90
|
4.8
|
59.0
|
1.0
|
CA
|
I:CYS119
|
4.8
|
54.0
|
1.0
|
N
|
I:HIS121
|
4.8
|
53.0
|
1.0
|
CB
|
I:LYS88
|
4.9
|
59.5
|
1.0
|
C
|
I:LYS88
|
4.9
|
59.5
|
1.0
|
|
Zinc binding site 6 out
of 8 in 8oev
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Zinc Binding Sites List in 8oev
Zinc binding site 6 out
of 8 in the Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3)
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 6 of Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
I:Zn202
b:115.1
occ:1.00
|
SG
|
I:CYS39
|
2.3
|
89.8
|
1.0
|
SG
|
I:CYS42
|
2.3
|
94.5
|
1.0
|
SG
|
I:CYS20
|
2.3
|
82.0
|
1.0
|
SG
|
I:CYS17
|
2.3
|
81.2
|
1.0
|
CB
|
I:CYS17
|
3.2
|
81.2
|
1.0
|
CB
|
I:CYS39
|
3.3
|
89.8
|
1.0
|
CB
|
I:CYS42
|
3.6
|
94.5
|
1.0
|
N
|
I:CYS20
|
3.8
|
82.0
|
1.0
|
CB
|
I:CYS20
|
3.9
|
82.0
|
1.0
|
N
|
I:CYS42
|
3.9
|
94.5
|
1.0
|
CB
|
I:GLU19
|
4.3
|
87.8
|
1.0
|
CA
|
I:CYS42
|
4.3
|
94.5
|
1.0
|
CB
|
I:TYR44
|
4.3
|
87.2
|
1.0
|
CA
|
I:CYS20
|
4.3
|
82.0
|
1.0
|
N
|
I:GLU19
|
4.6
|
87.8
|
1.0
|
C
|
I:GLU19
|
4.7
|
87.8
|
1.0
|
CA
|
I:CYS17
|
4.7
|
81.2
|
1.0
|
CA
|
I:CYS39
|
4.7
|
89.8
|
1.0
|
CA
|
I:GLU19
|
4.8
|
87.8
|
1.0
|
C
|
I:CYS42
|
4.8
|
94.5
|
1.0
|
CG
|
I:GLU19
|
4.8
|
87.8
|
1.0
|
CB
|
I:ASN22
|
4.8
|
74.0
|
1.0
|
C
|
I:CYS20
|
4.9
|
82.0
|
1.0
|
N
|
I:ASN22
|
4.9
|
74.0
|
1.0
|
N
|
I:ASN21
|
4.9
|
75.5
|
1.0
|
CB
|
I:ASN41
|
4.9
|
88.9
|
1.0
|
N
|
I:TYR44
|
5.0
|
87.2
|
1.0
|
|
Zinc binding site 7 out
of 8 in 8oev
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Zinc Binding Sites List in 8oev
Zinc binding site 7 out
of 8 in the Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3)
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 7 of Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
J:Zn101
b:31.5
occ:1.00
|
SG
|
J:CYS45
|
2.3
|
16.5
|
1.0
|
SG
|
J:CYS10
|
2.3
|
14.2
|
1.0
|
SG
|
J:CYS44
|
2.3
|
15.1
|
1.0
|
SG
|
J:CYS7
|
2.3
|
10.8
|
1.0
|
N
|
J:CYS45
|
3.2
|
16.5
|
1.0
|
CB
|
J:CYS7
|
3.2
|
10.8
|
1.0
|
CB
|
J:CYS10
|
3.5
|
14.2
|
1.0
|
CB
|
J:CYS45
|
3.5
|
16.5
|
1.0
|
CB
|
J:CYS44
|
3.6
|
15.1
|
1.0
|
CA
|
J:CYS45
|
3.6
|
16.5
|
1.0
|
C
|
J:CYS44
|
3.6
|
15.1
|
1.0
|
N
|
J:CYS10
|
3.9
|
14.2
|
1.0
|
NE
|
J:ARG42
|
4.1
|
14.6
|
1.0
|
O
|
J:CYS44
|
4.1
|
15.1
|
1.0
|
CA
|
J:CYS44
|
4.2
|
15.1
|
1.0
|
CA
|
J:CYS10
|
4.3
|
14.2
|
1.0
|
NH2
|
J:ARG42
|
4.5
|
14.6
|
1.0
|
CB
|
J:LYS12
|
4.6
|
13.8
|
1.0
|
CA
|
J:CYS7
|
4.6
|
10.8
|
1.0
|
CB
|
J:THR9
|
4.7
|
14.5
|
1.0
|
CZ
|
J:ARG42
|
4.8
|
14.6
|
1.0
|
CB
|
J:ARG42
|
4.8
|
14.6
|
1.0
|
N
|
J:GLY11
|
4.8
|
13.5
|
1.0
|
N
|
J:LYS12
|
4.9
|
13.8
|
1.0
|
N
|
J:CYS44
|
4.9
|
15.1
|
1.0
|
C
|
J:CYS10
|
4.9
|
14.2
|
1.0
|
C
|
J:THR9
|
5.0
|
14.5
|
1.0
|
CD
|
J:ARG42
|
5.0
|
14.6
|
1.0
|
|
Zinc binding site 8 out
of 8 in 8oev
Go back to
Zinc Binding Sites List in 8oev
Zinc binding site 8 out
of 8 in the Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3)
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 8 of Structure of the Mammalian Pol II-SPT6-Elongin Complex, Lacking Eloa Latch (Composite Structure, Structure 3) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
L:Zn101
b:118.8
occ:1.00
|
SG
|
L:CYS22
|
2.3
|
61.2
|
1.0
|
SG
|
L:CYS19
|
2.3
|
54.1
|
1.0
|
SG
|
L:CYS36
|
2.3
|
63.5
|
1.0
|
SG
|
L:CYS39
|
2.3
|
64.3
|
1.0
|
CB
|
L:CYS19
|
3.0
|
54.1
|
1.0
|
CB
|
L:CYS36
|
3.1
|
63.5
|
1.0
|
CB
|
L:CYS22
|
3.2
|
61.2
|
1.0
|
CB
|
L:CYS39
|
3.8
|
64.3
|
1.0
|
N
|
L:CYS22
|
3.9
|
61.2
|
1.0
|
N
|
L:CYS39
|
4.0
|
64.3
|
1.0
|
CA
|
L:CYS22
|
4.1
|
61.2
|
1.0
|
OG1
|
L:THR24
|
4.2
|
59.0
|
1.0
|
CB
|
L:TYR41
|
4.4
|
49.9
|
1.0
|
CA
|
L:CYS39
|
4.4
|
64.3
|
1.0
|
CA
|
L:CYS19
|
4.5
|
54.1
|
1.0
|
CB
|
L:GLU38
|
4.6
|
68.7
|
1.0
|
CA
|
L:CYS36
|
4.6
|
63.5
|
1.0
|
C
|
L:CYS22
|
4.8
|
61.2
|
1.0
|
N
|
L:TYR41
|
4.8
|
49.9
|
1.0
|
OE1
|
L:GLU38
|
4.9
|
68.7
|
1.0
|
C
|
L:CYS39
|
4.9
|
64.3
|
1.0
|
ND2
|
L:ASN26
|
5.0
|
61.0
|
1.0
|
N
|
L:GLY40
|
5.0
|
57.4
|
1.0
|
|
Reference:
Y.Chen,
G.Kokic,
C.Dienemann,
O.Dybkov,
H.Urlaub,
P.Cramer.
Structure of Transcribing Rna Polymerase II-Elongin Complex Nat.Struct.Mol.Biol. 2023.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-023-01138-W
Page generated: Thu Oct 31 08:44:12 2024
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