Zinc in PDB 8jyj: Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid A

All present enzymatic activity of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid A:
3.1.26.13;

The structure of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid A, PDB code: 8jyj was solved by Y.Ito, H.Lu, M.Kitajima, H.Ishikawa, Y.Nakata, Y.Iwatani, T.Hoshino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.72 / 2.01
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	61.836, 61.836, 83.624, 90, 90, 90
R / Rfree (%)	24.3 / 29.8

The structure of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid A also contains other interesting chemical elements:

Manganese

(Mn)

2 atoms

The binding sites of Zinc atom in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid A (pdb code 8jyj). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid A, PDB code: 8jyj:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid A within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn204 b:54.4 occ:1.00 O A:HOH320 2.1 36.5 1.0 OE1 A:GLU136 2.2 56.9 1.0 NE2 A:HIS129 2.3 60.9 1.0 CD A:GLU136 2.8 56.5 1.0 OE2 A:GLU136 2.8 58.1 1.0 CD2 A:HIS129 3.0 63.2 1.0 CE1 A:HIS129 3.4 60.1 1.0 CA A:GLY133 3.6 62.8 1.0 C A:GLY133 3.9 65.3 1.0 N A:GLY134 4.1 51.6 1.0 N A:GLY133 4.1 79.4 1.0 N A:ASN135 4.1 55.1 1.0 CG A:GLU136 4.2 74.5 1.0 CG A:HIS129 4.2 63.6 1.0 CB A:ASN135 4.2 57.9 1.0 O A:HOH306 4.4 63.7 1.0 ND1 A:HIS129 4.4 53.4 1.0 O A:GLY133 4.6 57.7 1.0 N A:GLU136 4.6 47.4 1.0 CA A:ASN135 4.7 52.7 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid A within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn205 b:61.6 occ:1.00 OE2 A:GLU119 1.9 67.4 1.0 O A:HOH319 2.1 43.6 1.0 OE2 A:GLU72 2.1 60.5 1.0 CD A:GLU119 3.0 65.3 1.0 CD A:GLU72 3.1 53.9 1.0 CG A:GLU72 3.3 50.5 1.0 OE1 A:GLU119 3.6 62.8 1.0 CG A:GLU119 4.2 61.0 1.0 OE1 A:GLU72 4.2 58.7 1.0 CB A:GLU72 4.8 43.5 1.0

Y.Ito, H.Lu, M.Kitajima, H.Ishikawa, Y.Nakata, Y.Iwatani, T.Hoshino. Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid A To Be Published.