Zinc in PDB 8jyh: Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C

All present enzymatic activity of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C:
3.1.26.13;

The structure of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C, PDB code: 8jyh was solved by Y.Ito, H.Lu, M.Kitajima, H.Ishikawa, Y.Nakata, Y.Iwatani, T.Hoshino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.73 / 2.21
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	61.85, 61.85, 82.337, 90, 90, 90
R / Rfree (%)	22.8 / 28.2

The structure of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C also contains other interesting chemical elements:

Manganese

(Mn)

2 atoms

The binding sites of Zinc atom in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C (pdb code 8jyh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C, PDB code: 8jyh:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn204 b:56.3 occ:1.00 OE1 A:GLU136 2.1 61.3 1.0 O A:HOH309 2.2 48.9 1.0 NE2 A:HIS129 2.3 59.3 1.0 CD A:GLU136 2.7 72.5 1.0 OE2 A:GLU136 2.8 70.8 1.0 CD2 A:HIS129 3.2 64.5 1.0 CE1 A:HIS129 3.2 68.6 1.0 CA A:GLY133 3.7 70.7 1.0 O A:HOH303 3.9 60.0 1.0 C A:GLY133 4.0 68.7 1.0 N A:GLY134 4.0 65.2 1.0 CG A:GLU136 4.1 73.7 1.0 N A:ASN135 4.2 62.4 1.0 N A:GLY133 4.3 75.7 1.0 ND1 A:HIS129 4.3 65.5 1.0 CG A:HIS129 4.3 71.6 1.0 CB A:ASN135 4.5 65.0 1.0 O A:GLY133 4.6 63.7 1.0 N A:GLU136 4.7 59.5 1.0 CA A:ASN135 4.9 57.0 1.0 C A:GLY134 5.0 65.3 1.0 CA A:GLY134 5.0 60.7 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn205 b:63.2 occ:1.00 OE1 A:GLU119 1.8 73.1 1.0 OE2 A:GLU72 2.0 61.7 1.0 O A:HOH308 2.2 53.4 1.0 CD A:GLU119 2.8 69.9 1.0 CD A:GLU72 3.0 63.6 1.0 OE2 A:GLU119 3.1 78.2 1.0 CG A:GLU72 3.3 61.4 1.0 CG A:GLU119 4.1 64.8 1.0 OE1 A:GLU72 4.2 57.9 1.0 CE A:LYS120 4.6 68.8 1.0 CB A:GLU72 4.8 54.8 1.0 CB A:GLU119 4.8 62.9 1.0

Y.Ito, H.Lu, M.Kitajima, H.Ishikawa, Y.Nakata, Y.Iwatani, T.Hoshino. Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C To Be Published.