Zinc in PDB 8j80: Cryo-Em Structure of HZNT7-Fab Complex in Zinc State 1, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing Zinc- Bound and the Other in An Outward-Facing Zinc-Unbound Conformation

The binding sites of Zinc atom in the Cryo-Em Structure of HZNT7-Fab Complex in Zinc State 1, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing Zinc- Bound and the Other in An Outward-Facing Zinc-Unbound Conformation (pdb code 8j80). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryo-Em Structure of HZNT7-Fab Complex in Zinc State 1, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing Zinc- Bound and the Other in An Outward-Facing Zinc-Unbound Conformation, PDB code: 8j80:

Zinc binding site 1 out of 1 in the Cryo-Em Structure of HZNT7-Fab Complex in Zinc State 1, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing Zinc- Bound and the Other in An Outward-Facing Zinc-Unbound Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of HZNT7-Fab Complex in Zinc State 1, Determined in Heterogeneous Conformations- One Subunit in An Inward-Facing Zinc- Bound and the Other in An Outward-Facing Zinc-Unbound Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn401 b:167.2 occ:1.00 OD2 B:ASP74 2.0 113.7 1.0 OD2 B:ASP244 2.0 128.5 1.0 NE2 B:HIS70 2.1 108.2 1.0 ND1 B:HIS164 2.1 121.3 1.0 OD1 B:ASP74 2.1 105.6 1.0 CG B:ASP74 2.3 105.3 1.0 CE1 B:HIS164 2.5 123.9 1.0 CE1 B:HIS70 2.5 104.5 1.0 CD2 B:HIS70 3.1 104.0 1.0 CG B:ASP244 3.2 124.7 1.0 CG B:HIS164 3.3 123.8 1.0 ND1 B:HIS70 3.6 100.4 1.0 OD1 B:ASP244 3.8 125.1 1.0 NE2 B:HIS164 3.8 124.5 1.0 CB B:ASP74 3.8 99.7 1.0 CG B:HIS70 3.8 98.8 1.0 CB B:HIS164 4.0 126.7 1.0 CD2 B:HIS164 4.2 121.6 1.0 O B:HIS70 4.3 106.8 1.0 CB B:ASP244 4.4 122.6 1.0 CA B:ASP74 4.7 98.8 1.0 O B:ALA243 4.9 117.7 1.0 C B:HIS70 5.0 101.9 1.0

H.B.Bui, S.Watanabe, N.Nomura, K.Liu, T.Uemura, M.Inoue, A.Tsutsumi, H.Fujita, K.Kinoshita, Y.Kato, S.Iwata, M.Kikkawa, K.Inaba. Cryo-Em Structures of Human Zinc Transporter ZNT7 Reveal the Mechanism of Zn 2+ Uptake Into the Golgi Apparatus. Nat Commun V. 14 4770 2023.
ISSN: ESSN 2041-1723
PubMed: 37553324
DOI: 10.1038/S41467-023-40521-5