Zinc in PDB 8j7u: Cryo-Em Structure of HZNT7-Fab Complex in Zinc-Bound State, Determined in Outward-Facing Conformation

The binding sites of Zinc atom in the Cryo-Em Structure of HZNT7-Fab Complex in Zinc-Bound State, Determined in Outward-Facing Conformation (pdb code 8j7u). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryo-Em Structure of HZNT7-Fab Complex in Zinc-Bound State, Determined in Outward-Facing Conformation, PDB code: 8j7u:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Cryo-Em Structure of HZNT7-Fab Complex in Zinc-Bound State, Determined in Outward-Facing Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of HZNT7-Fab Complex in Zinc-Bound State, Determined in Outward-Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:208.8 occ:1.00 OD1 A:ASP74 2.0 150.6 1.0 OD2 A:ASP74 2.0 153.0 1.0 NE2 A:HIS240 2.0 139.0 1.0 OD1 A:ASP244 2.1 153.0 1.0 CG A:ASP74 2.2 149.2 1.0 CD2 A:HIS240 2.5 135.9 1.0 CG A:ASP244 2.9 151.9 1.0 OD2 A:ASP244 3.0 155.4 1.0 CE1 A:HIS240 3.3 133.5 1.0 CB A:ASP74 3.8 144.8 1.0 CG A:HIS240 3.8 133.4 1.0 ND1 A:HIS240 4.1 131.2 1.0 O A:HIS240 4.2 128.8 1.0 CB A:ASP244 4.3 149.5 1.0 CE2 A:PHE114 4.3 110.6 1.0 CD2 A:LEU115 4.4 106.1 1.0 NE2 A:HIS70 4.4 147.6 1.0 CE1 A:HIS70 4.4 146.1 1.0 CA A:ASP74 4.6 145.8 1.0 CZ A:PHE114 4.7 112.0 1.0 CA A:ASP244 4.8 151.0 1.0 N A:ASP244 4.8 150.8 1.0 C A:HIS240 4.9 131.6 1.0

Zinc binding site 2 out of 2 in the Cryo-Em Structure of HZNT7-Fab Complex in Zinc-Bound State, Determined in Outward-Facing Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of HZNT7-Fab Complex in Zinc-Bound State, Determined in Outward-Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn501 b:220.3 occ:1.00 OD2 B:ASP74 2.0 168.9 1.0 OD1 B:ASP244 2.0 153.5 1.0 OD2 B:ASP244 2.0 158.4 1.0 OD1 B:ASP74 2.0 168.7 1.0 NE2 B:HIS240 2.0 143.4 1.0 CG B:ASP74 2.1 168.3 1.0 CG B:ASP244 2.2 154.4 1.0 CD2 B:HIS240 2.8 139.0 1.0 CE1 B:HIS240 2.8 141.6 1.0 CB B:ASP74 3.4 165.8 1.0 ND1 B:HIS240 3.7 137.4 1.0 CG B:HIS240 3.7 136.0 1.0 CB B:ASP244 3.7 151.6 1.0 O B:HIS240 4.0 134.7 1.0 CA B:ASP74 4.2 165.2 1.0 CE1 B:HIS70 4.4 172.0 1.0 CA B:ASP244 4.5 149.5 1.0 NE2 B:HIS70 4.5 172.3 1.0 N B:ASP244 4.7 149.9 1.0 C B:HIS240 4.8 134.2 1.0 N B:ASP74 5.0 163.8 1.0

H.B.Bui, S.Watanabe, N.Nomura, K.Liu, T.Uemura, M.Inoue, A.Tsutsumi, H.Fujita, K.Kinoshita, Y.Kato, S.Iwata, M.Kikkawa, K.Inaba. Cryo-Em Structures of Human Zinc Transporter ZNT7 Reveal the Mechanism of Zn 2+ Uptake Into the Golgi Apparatus. Nat Commun V. 14 4770 2023.
ISSN: ESSN 2041-1723
PubMed: 37553324
DOI: 10.1038/S41467-023-40521-5