Zinc in PDB 8hy3: Crystal Structure of Human Secretory Glutaminyl Cyclase in Complex with 1-Benzyl-5-Methyl-1H-Imidazole

Enzymatic activity of Crystal Structure of Human Secretory Glutaminyl Cyclase in Complex with 1-Benzyl-5-Methyl-1H-Imidazole

All present enzymatic activity of Crystal Structure of Human Secretory Glutaminyl Cyclase in Complex with 1-Benzyl-5-Methyl-1H-Imidazole:
2.3.2.5;

Protein crystallography data

The structure of Crystal Structure of Human Secretory Glutaminyl Cyclase in Complex with 1-Benzyl-5-Methyl-1H-Imidazole, PDB code: 8hy3 was solved by G.-B.Li, J.Deng, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.62 / 1.95
Space group F 41 3 2
Cell size a, b, c (Å), α, β, γ (°) 273.952, 273.952, 273.952, 90, 90, 90
R / Rfree (%) 22.6 / 25.8

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Human Secretory Glutaminyl Cyclase in Complex with 1-Benzyl-5-Methyl-1H-Imidazole (pdb code 8hy3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human Secretory Glutaminyl Cyclase in Complex with 1-Benzyl-5-Methyl-1H-Imidazole, PDB code: 8hy3:

Zinc binding site 1 out of 1 in 8hy3

Go back to Zinc Binding Sites List in 8hy3
Zinc binding site 1 out of 1 in the Crystal Structure of Human Secretory Glutaminyl Cyclase in Complex with 1-Benzyl-5-Methyl-1H-Imidazole


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Secretory Glutaminyl Cyclase in Complex with 1-Benzyl-5-Methyl-1H-Imidazole within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:56.2
occ:1.00
 OD2 A:ASP159 1.9 64.7 1.0
NE2 A:HIS330 2.0 59.7 1.0
N04 A:4Q8402 2.0 57.2 1.0
OE2 A:GLU202 2.1 69.8 1.0
OE1 A:GLU202 2.5 64.0 1.0
CD A:GLU202 2.6 60.6 1.0
C05 A:4Q8402 2.9 62.2 1.0
CE1 A:HIS330 3.0 57.3 1.0
CG A:ASP159 3.0 59.3 1.0
CD2 A:HIS330 3.0 66.1 1.0
H051 A:4Q8402 3.0 74.7 1.0
C03 A:4Q8402 3.1 59.5 1.0
HD2 A:HIS330 3.2 79.3 1.0
HE1 A:HIS330 3.2 68.8 1.0
H031 A:4Q8402 3.4 71.4 1.0
OD1 A:ASP159 3.4 59.3 1.0
HE1 A:TRP329 3.5 73.8 1.0
NE1 A:TRP329 3.9 61.5 1.0
ND1 A:HIS330 4.1 61.7 1.0
HD21 A:LEU249 4.1 75.4 1.0
N06 A:4Q8402 4.1 65.6 1.0
CG A:GLU202 4.1 60.6 1.0
CG A:HIS330 4.1 59.1 1.0
HE2 A:HIS140 4.1 73.9 1.0
HB2 A:LYS144 4.1 76.4 1.0
C02 A:4Q8402 4.2 62.2 1.0
CB A:ASP159 4.2 66.4 1.0
HZ2 A:TRP329 4.2 79.8 1.0
HB3 A:ASP159 4.3 79.7 1.0
HD2 A:LYS144 4.3 75.8 1.0
HG2 A:GLU202 4.3 72.7 1.0
HB2 A:ASP159 4.4 79.7 1.0
HG3 A:GLU202 4.4 72.7 1.0
OE1 A:GLU201 4.5 59.7 1.0
CE2 A:TRP329 4.5 60.2 1.0
CZ2 A:TRP329 4.6 66.5 1.0
HE1 A:HIS140 4.7 72.7 1.0
NE2 A:HIS140 4.7 61.6 1.0
HZ A:PHE154 4.8 77.3 1.0
CD1 A:TRP329 4.8 63.7 1.0
O A:HOH502 4.8 59.0 1.0
HD1 A:HIS330 4.8 74.1 1.0
CD2 A:LEU249 4.9 62.9 1.0
HB3 A:GLU202 4.9 69.7 1.0
CB A:LYS144 5.0 63.7 1.0
HD1 A:TRP329 5.0 76.5 1.0
CE1 A:HIS140 5.0 60.6 1.0

Reference:

G.-B.Li, J.Deng. Crystal Structure of Human Secretory Glutaminyl Cyclase in Complex with 1-Benzyl-5-Methyl-1H-Imidazole To Be Published.
Page generated: Thu Oct 31 07:32:19 2024

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