Zinc in PDB 8hlw: Crystal Structure of SIRT3 in Complex with H4K16LA Peptide

All present enzymatic activity of Crystal Structure of SIRT3 in Complex with H4K16LA Peptide:
2.3.1.286;

The structure of Crystal Structure of SIRT3 in Complex with H4K16LA Peptide, PDB code: 8hlw was solved by F.Zhuming, Q.Hao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.24 / 2.50
Space group	P 65
Cell size a, b, c (Å), α, β, γ (°)	97.449, 97.449, 53.583, 90, 90, 120
R / Rfree (%)	18.8 / 24.3

The binding sites of Zinc atom in the Crystal Structure of SIRT3 in Complex with H4K16LA Peptide (pdb code 8hlw). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of SIRT3 in Complex with H4K16LA Peptide, PDB code: 8hlw:

Zinc binding site 1 out of 1 in the Crystal Structure of SIRT3 in Complex with H4K16LA Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of SIRT3 in Complex with H4K16LA Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:39.9 occ:1.00 SG A:CYS256 2.3 34.6 1.0 SG A:CYS280 2.3 42.8 1.0 SG A:CYS283 2.3 42.3 1.0 SG A:CYS259 2.3 48.6 1.0 HB2 A:CYS280 2.9 45.6 1.0 HB3 A:CYS280 3.0 45.6 1.0 CB A:CYS280 3.0 38.8 1.0 H A:CYS259 3.0 46.2 1.0 HB3 A:CYS259 3.3 58.2 1.0 CB A:CYS256 3.3 34.5 1.0 H A:CYS283 3.3 64.9 1.0 HB3 A:CYS256 3.3 39.5 1.0 HB2 A:CYS256 3.4 39.5 1.0 CB A:CYS259 3.4 48.2 1.0 HB3 A:CYS283 3.6 62.6 1.0 CB A:CYS283 3.6 51.9 1.0 HB A:VAL258 3.6 43.5 1.0 N A:CYS259 3.8 38.2 1.0 H A:GLY285 3.8 42.5 1.0 HB A:VAL282 3.9 76.8 1.0 N A:CYS283 4.0 53.8 1.0 HB2 A:ARG261 4.1 54.1 1.0 CA A:CYS259 4.1 47.2 1.0 HG12 A:VAL282 4.2 74.2 1.0 HB2 A:CYS259 4.2 58.2 1.0 H A:ARG261 4.2 60.5 1.0 CA A:CYS283 4.3 43.0 1.0 H A:VAL258 4.3 43.6 1.0 HB2 A:CYS283 4.4 62.6 1.0 HA3 A:GLY285 4.4 47.0 1.0 H A:VAL282 4.5 72.5 1.0 CA A:CYS280 4.5 41.1 1.0 CB A:VAL258 4.6 35.9 1.0 HB3 A:ARG261 4.6 54.1 1.0 N A:GLY285 4.6 36.2 1.0 HE2 A:PHE263 4.6 50.7 1.0 H A:GLN260 4.6 55.6 1.0 HD2 A:ARG261 4.7 63.1 1.0 H A:THR284 4.7 47.3 1.0 HZ A:PHE263 4.7 49.4 1.0 CB A:VAL282 4.7 63.7 1.0 C A:CYS259 4.7 46.8 1.0 CA A:CYS256 4.8 32.2 1.0 C A:CYS283 4.8 41.1 1.0 CB A:ARG261 4.8 44.8 1.0 HA A:CYS280 4.8 49.7 1.0 CG1 A:VAL282 4.9 61.5 1.0 N A:THR284 4.9 41.0 1.0 C A:VAL258 4.9 38.7 1.0 N A:GLN260 4.9 46.0 1.0 C A:VAL282 5.0 59.6 1.0 CA A:GLY285 5.0 38.8 1.0 HA A:CYS259 5.0 57.0 1.0

Z.Fan, Z.Liu, N.Zhang, W.Wei, K.Cheng, H.Sun, Q.Hao. Identification of SIRT3 As An Eraser of H4K16LA. Iscience V. 26 07757 2023.
ISSN: ESSN 2589-0042
PubMed: 37720100
DOI: 10.1016/J.ISCI.2023.107757