Zinc in PDB 8hih: Cryo-Em Structure of Mycobacterium Tuberculosis Transcription Initiation Complex with Transcription Factor Glnr

All present enzymatic activity of Cryo-Em Structure of Mycobacterium Tuberculosis Transcription Initiation Complex with Transcription Factor Glnr:
2.7.7.6;

The structure of Cryo-Em Structure of Mycobacterium Tuberculosis Transcription Initiation Complex with Transcription Factor Glnr also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Zinc atom in the Cryo-Em Structure of Mycobacterium Tuberculosis Transcription Initiation Complex with Transcription Factor Glnr (pdb code 8hih). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryo-Em Structure of Mycobacterium Tuberculosis Transcription Initiation Complex with Transcription Factor Glnr, PDB code: 8hih:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Cryo-Em Structure of Mycobacterium Tuberculosis Transcription Initiation Complex with Transcription Factor Glnr


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Mycobacterium Tuberculosis Transcription Initiation Complex with Transcription Factor Glnr within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn2000 b:319.1 occ:1.00 SG D:CYS891 2.3 245.5 1.0 SG D:CYS978 2.3 232.3 1.0 CA D:CYS968 2.6 242.2 1.0 CG2 D:THR893 2.7 234.6 1.0 N D:ALA969 2.9 237.5 1.0 O D:THR967 3.1 239.8 1.0 C D:CYS968 3.3 242.2 1.0 SG D:CYS968 3.4 242.2 1.0 CB D:CYS968 3.4 242.2 1.0 N D:CYS968 3.5 242.2 1.0 C D:THR967 3.6 239.8 1.0 CB D:THR893 3.7 234.6 1.0 CB D:CYS891 3.8 245.5 1.0 CB D:CYS978 3.9 232.3 1.0 SG D:CYS975 4.0 228.2 1.0 CA D:ALA969 4.2 237.5 1.0 CB D:ALA969 4.4 237.5 1.0 O D:CYS968 4.5 242.2 1.0 OG1 D:THR893 4.5 234.6 1.0 O D:SER964 4.7 241.6 1.0 CG D:ARG963 4.7 244.9 1.0 N D:THR893 4.8 234.6 1.0 CA D:THR893 4.8 234.6 1.0 N D:THR970 4.9 237.8 1.0

Zinc binding site 2 out of 2 in the Cryo-Em Structure of Mycobacterium Tuberculosis Transcription Initiation Complex with Transcription Factor Glnr


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of Mycobacterium Tuberculosis Transcription Initiation Complex with Transcription Factor Glnr within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn2001 b:290.0 occ:1.00 SG D:CYS78 2.3 236.8 1.0 SG D:CYS62 2.3 253.1 1.0 SG D:CYS75 2.3 255.6 1.0 SG D:CYS60 2.3 252.5 1.0 CB D:CYS75 3.0 255.6 1.0 CB D:LYS64 3.5 260.7 1.0 CB D:CYS60 3.5 252.5 1.0 N D:CYS62 3.6 253.1 1.0 N D:LYS64 3.8 260.7 1.0 CB D:CYS62 3.8 253.1 1.0 CB D:CYS78 3.9 236.8 1.0 N D:CYS78 4.1 236.8 1.0 CA D:CYS62 4.1 253.1 1.0 N D:TYR61 4.2 233.8 1.0 N D:GLY63 4.3 254.2 1.0 CA D:LYS64 4.3 260.7 1.0 C D:CYS62 4.4 253.1 1.0 CA D:CYS75 4.5 255.6 1.0 NH2 D:ARG77 4.5 241.9 1.0 C D:CYS60 4.6 252.5 1.0 CA D:CYS78 4.6 236.8 1.0 CG D:LYS64 4.6 260.7 1.0 CA D:CYS60 4.7 252.5 1.0 C D:TYR61 4.7 233.8 1.0 CB D:ARG77 4.8 241.9 1.0 CA D:TYR61 4.9 233.8 1.0 C D:GLY63 4.9 254.2 1.0 C D:CYS75 5.0 255.6 1.0 NE D:ARG77 5.0 241.9 1.0 CB D:TYR61 5.0 233.8 1.0

J.Shi, Z.Feng, J.Xu, F.Li, Y.Zhang, A.Wen, F.Wang, Q.Song, L.Wang, H.Cui, S.Tong, P.Chen, Y.Zhu, G.Zhao, S.Wang, Y.Feng, W.Lin. Structural Insights Into the Transcription Activation Mechanism of the Global Regulator Glnr From Actinobacteria. Proc.Natl.Acad.Sci.Usa V. 120 82120 2023.
ISSN: ESSN 1091-6490
PubMed: 37216560
DOI: 10.1073/PNAS.2300282120