Zinc in PDB 8heo: Crystal Structure of SIAH1 Sbd Bound to AXIN2 Peptide

All present enzymatic activity of Crystal Structure of SIAH1 Sbd Bound to AXIN2 Peptide:
2.3.2.27;

The structure of Crystal Structure of SIAH1 Sbd Bound to AXIN2 Peptide, PDB code: 8heo was solved by X.X.Yan, L.F.Tian, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.20 / 2.53
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	40.818, 87.932, 59.698, 90, 101.57, 90
R / Rfree (%)	20.7 / n/a

The binding sites of Zinc atom in the Crystal Structure of SIAH1 Sbd Bound to AXIN2 Peptide (pdb code 8heo). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of SIAH1 Sbd Bound to AXIN2 Peptide, PDB code: 8heo:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Crystal Structure of SIAH1 Sbd Bound to AXIN2 Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of SIAH1 Sbd Bound to AXIN2 Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:72.5 occ:1.00 NE2 A:HIS117 1.9 89.6 1.0 SG A:CYS98 2.3 72.0 1.0 SG A:CYS121 2.3 83.9 1.0 SG A:CYS105 2.5 68.0 1.0 CE1 A:HIS117 2.7 88.9 1.0 CD2 A:HIS117 2.8 86.4 1.0 CB A:CYS121 3.0 83.3 1.0 CB A:CYS98 3.0 74.9 1.0 CB A:CYS105 3.4 70.8 1.0 ND1 A:HIS117 3.8 88.3 1.0 CG A:HIS117 3.9 88.6 1.0 CA A:CYS121 4.3 84.0 1.0 CA A:CYS98 4.5 75.4 1.0 O A:HIS117 4.6 96.4 1.0 CD2 A:TYR100 4.7 70.0 1.0 CG1 A:ILE107 4.8 79.5 1.0 CB A:TYR100 4.8 73.3 1.0 CA A:CYS105 4.8 71.8 1.0 CD1 A:PHE123 5.0 78.7 1.0 CB A:ILE107 5.0 77.6 1.0

Zinc binding site 2 out of 4 in the Crystal Structure of SIAH1 Sbd Bound to AXIN2 Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of SIAH1 Sbd Bound to AXIN2 Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:74.6 occ:1.00 NE2 A:HIS152 2.0 70.0 1.0 NE2 A:HIS147 2.1 60.4 1.0 SG A:CYS135 2.4 74.4 1.0 SG A:CYS128 2.4 82.5 1.0 CE1 A:HIS152 2.8 70.3 1.0 CE1 A:HIS147 3.0 60.8 1.0 CB A:CYS128 3.1 80.6 1.0 CD2 A:HIS147 3.2 67.9 1.0 CD2 A:HIS152 3.2 74.2 1.0 CB A:CYS135 3.5 80.9 1.0 ND1 A:HIS152 4.0 73.7 1.0 ND1 A:HIS147 4.1 67.0 1.0 CG A:HIS152 4.2 76.4 1.0 CG A:HIS147 4.2 61.7 1.0 CA A:CYS128 4.4 77.8 1.0 O A:CYS135 4.4 83.4 1.0 CB A:TRP137 4.6 69.7 1.0 CA A:CYS135 4.7 84.2 1.0 C A:CYS135 4.8 78.4 1.0 CB A:CYS130 4.8 65.0 1.0 CD2 A:LEU148 4.8 69.7 1.0

Zinc binding site 3 out of 4 in the Crystal Structure of SIAH1 Sbd Bound to AXIN2 Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of SIAH1 Sbd Bound to AXIN2 Peptide within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn301 b:87.4 occ:1.00 NE2 B:HIS117 1.9 88.2 1.0 SG B:CYS105 2.2 86.4 1.0 SG B:CYS121 2.4 98.3 1.0 SG B:CYS98 2.6 91.9 1.0 CD2 B:HIS117 2.7 89.9 1.0 CE1 B:HIS117 3.0 91.8 1.0 CB B:CYS98 3.2 84.9 1.0 CB B:CYS121 3.2 93.2 1.0 CD1 B:ILE107 3.4 98.1 1.0 CB B:CYS105 3.6 90.6 1.0 CG1 B:ILE107 3.9 95.1 1.0 CG B:HIS117 4.0 86.2 1.0 ND1 B:HIS117 4.1 89.2 1.0 CA B:CYS121 4.4 92.1 1.0 CA B:CYS98 4.6 81.6 1.0 CD2 B:PHE123 4.7 97.2 1.0 CD2 B:TYR100 4.7 80.0 1.0 CB B:TYR100 4.8 89.5 1.0 O B:HIS117 4.8 92.6 1.0 CA B:CYS105 4.9 92.2 1.0 CG B:GLU118 5.0 85.2 1.0

Zinc binding site 4 out of 4 in the Crystal Structure of SIAH1 Sbd Bound to AXIN2 Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of SIAH1 Sbd Bound to AXIN2 Peptide within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn302 b:105.3 occ:1.00 SG B:CYS135 2.1 117.6 1.0 NE2 B:HIS147 2.2 105.8 1.0 CB B:CYS128 2.2 85.1 1.0 NE2 B:HIS152 2.3 99.2 1.0 SG B:CYS128 2.6 94.6 1.0 CE1 B:HIS152 2.7 110.1 1.0 CE1 B:HIS147 3.2 107.4 1.0 CB B:TRP137 3.2 99.7 1.0 CD2 B:HIS147 3.3 108.9 1.0 CB B:CYS135 3.4 111.7 1.0 CA B:CYS128 3.4 85.1 1.0 CD2 B:HIS152 3.5 102.7 1.0 ND1 B:HIS152 3.9 105.6 1.0 CG B:TRP137 4.0 103.5 1.0 N B:TRP137 4.0 104.4 1.0 CA B:TRP137 4.1 97.6 1.0 CE3 B:TRP137 4.1 100.7 1.0 N B:CYS128 4.1 85.9 1.0 CD2 B:TRP137 4.2 103.0 1.0 O B:TRP137 4.3 100.0 1.0 ND1 B:HIS147 4.3 108.6 1.0 CG B:HIS152 4.4 100.1 1.0 CG B:HIS147 4.4 109.5 1.0 C B:TRP137 4.6 99.3 1.0 C B:CYS128 4.6 81.5 1.0 CA B:CYS135 4.7 109.1 1.0 C B:CYS135 4.7 106.1 1.0 N B:LYS136 4.8 105.2 1.0

X.X.Yan, L.F.Tian. Crystal Structure of SIAH1 Sbd Bound to AXIN2 Peptide To Be Published.