Zinc in PDB 8gvx: Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2

Other elements in 8gvx:

The structure of Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2 also contains other interesting chemical elements:

Calcium (Ca) 4 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2 (pdb code 8gvx). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2, PDB code: 8gvx:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 8gvx

Go back to Zinc Binding Sites List in 8gvx
Zinc binding site 1 out of 4 in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn803

b:198.3
occ:1.00
 ND1 B:HIS172 2.1 159.2 1.0
SG B:CYS178 2.3 194.1 1.0
SG B:CYS181 2.3 194.9 1.0
SG B:CYS176 2.3 182.4 1.0
CE1 B:HIS172 2.6 159.2 1.0
CG B:HIS172 3.1 159.2 1.0
CB B:CYS181 3.1 194.9 1.0
CB B:CYS178 3.6 194.1 1.0
NE2 B:HIS172 3.6 159.2 1.0
CB B:CYS176 3.7 182.4 1.0
CB B:HIS172 3.8 159.2 1.0
CD2 B:HIS172 3.9 159.2 1.0
N B:CYS181 4.1 194.9 1.0
CA B:CYS181 4.2 194.9 1.0
N B:CYS178 4.3 194.1 1.0
CA B:CYS178 4.5 194.1 1.0
CG B:GLU180 4.5 192.9 1.0
OE2 B:GLU180 4.8 192.9 1.0
CA B:CYS176 4.8 182.4 1.0
C B:CYS176 4.9 182.4 1.0
C B:CYS178 5.0 194.1 1.0

Zinc binding site 2 out of 4 in 8gvx

Go back to Zinc Binding Sites List in 8gvx
Zinc binding site 2 out of 4 in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn803

b:198.3
occ:1.00
 ND1 A:HIS172 2.1 159.2 1.0
SG A:CYS178 2.3 194.1 1.0
SG A:CYS181 2.3 194.9 1.0
SG A:CYS176 2.3 182.4 1.0
CE1 A:HIS172 2.6 159.2 1.0
CG A:HIS172 3.1 159.2 1.0
CB A:CYS181 3.1 194.9 1.0
CB A:CYS178 3.6 194.1 1.0
NE2 A:HIS172 3.6 159.2 1.0
CB A:CYS176 3.7 182.4 1.0
CB A:HIS172 3.8 159.2 1.0
CD2 A:HIS172 3.9 159.2 1.0
N A:CYS181 4.1 194.9 1.0
CA A:CYS181 4.2 194.9 1.0
N A:CYS178 4.3 194.1 1.0
CA A:CYS178 4.5 194.1 1.0
CG A:GLU180 4.5 192.9 1.0
OE2 A:GLU180 4.8 192.9 1.0
CA A:CYS176 4.8 182.4 1.0
C A:CYS176 4.9 182.4 1.0
C A:CYS178 5.0 194.1 1.0

Zinc binding site 3 out of 4 in 8gvx

Go back to Zinc Binding Sites List in 8gvx
Zinc binding site 3 out of 4 in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn803

b:198.3
occ:1.00
 ND1 C:HIS172 2.1 159.2 1.0
SG C:CYS178 2.3 194.1 1.0
SG C:CYS181 2.3 194.9 1.0
SG C:CYS176 2.3 182.4 1.0
CE1 C:HIS172 2.6 159.2 1.0
CG C:HIS172 3.1 159.2 1.0
CB C:CYS181 3.1 194.9 1.0
CB C:CYS178 3.6 194.1 1.0
NE2 C:HIS172 3.6 159.2 1.0
CB C:CYS176 3.7 182.4 1.0
CB C:HIS172 3.8 159.2 1.0
CD2 C:HIS172 3.9 159.2 1.0
N C:CYS181 4.1 194.9 1.0
CA C:CYS181 4.2 194.9 1.0
N C:CYS178 4.3 194.1 1.0
CA C:CYS178 4.5 194.1 1.0
CG C:GLU180 4.5 192.9 1.0
OE2 C:GLU180 4.8 192.9 1.0
CA C:CYS176 4.8 182.4 1.0
C C:CYS176 4.9 182.4 1.0
C C:CYS178 5.0 194.1 1.0

Zinc binding site 4 out of 4 in 8gvx

Go back to Zinc Binding Sites List in 8gvx
Zinc binding site 4 out of 4 in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn803

b:198.3
occ:1.00
 ND1 D:HIS172 2.1 159.2 1.0
SG D:CYS178 2.3 194.1 1.0
SG D:CYS181 2.3 194.9 1.0
SG D:CYS176 2.3 182.4 1.0
CE1 D:HIS172 2.6 159.2 1.0
CG D:HIS172 3.1 159.2 1.0
CB D:CYS181 3.1 194.9 1.0
CB D:CYS178 3.6 194.1 1.0
NE2 D:HIS172 3.6 159.2 1.0
CB D:CYS176 3.7 182.4 1.0
CB D:HIS172 3.8 159.2 1.0
CD2 D:HIS172 3.9 159.2 1.0
N D:CYS181 4.1 194.9 1.0
CA D:CYS181 4.2 194.9 1.0
N D:CYS178 4.3 194.1 1.0
CA D:CYS178 4.5 194.1 1.0
CG D:GLU180 4.5 192.9 1.0
OE2 D:GLU180 4.8 192.9 1.0
CA D:CYS176 4.8 182.4 1.0
C D:CYS176 4.9 182.4 1.0
C D:CYS178 5.0 194.1 1.0

Reference:

J.Won, J.Kim, H.Jeong, J.Kim, S.Feng, B.Jeong, M.Kwak, J.Ko, W.Im, I.So, H.H.Lee. Molecular Architecture of the G Alpha I -Bound TRPC5 Ion Channel. Nat Commun V. 14 2550 2023.
ISSN: ESSN 2041-1723
PubMed: 37137991
DOI: 10.1038/S41467-023-38281-3
Page generated: Wed Oct 30 21:06:57 2024

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