Zinc in PDB 8gvw: Cryo-Em Structure of the Human TRPC5 Ion Channel in Lipid Nanodiscs, CLASS2

The structure of Cryo-Em Structure of the Human TRPC5 Ion Channel in Lipid Nanodiscs, CLASS2 also contains other interesting chemical elements:

Calcium

(Ca)

4 atoms

The binding sites of Zinc atom in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Lipid Nanodiscs, CLASS2 (pdb code 8gvw). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Lipid Nanodiscs, CLASS2, PDB code: 8gvw:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Lipid Nanodiscs, CLASS2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of the Human TRPC5 Ion Channel in Lipid Nanodiscs, CLASS2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn804 b:202.2 occ:1.00 ND1 A:HIS172 2.1 116.1 1.0 SG A:CYS181 2.3 127.1 1.0 SG A:CYS178 2.3 138.4 1.0 SG A:CYS176 2.3 132.7 1.0 CE1 A:HIS172 2.9 116.1 1.0 CG A:HIS172 3.2 116.1 1.0 CB A:CYS178 3.4 138.4 1.0 CB A:CYS181 3.5 127.1 1.0 CB A:CYS176 3.6 132.7 1.0 CB A:HIS172 3.7 116.1 1.0 NE2 A:HIS172 4.0 116.1 1.0 N A:CYS178 4.1 138.4 1.0 N A:CYS181 4.2 127.1 1.0 CD2 A:HIS172 4.2 116.1 1.0 CA A:CYS178 4.2 138.4 1.0 CA A:CYS181 4.4 127.1 1.0 OE1 A:GLU180 4.7 129.9 1.0 C A:CYS178 4.7 138.4 1.0 O A:CYS178 4.8 138.4 1.0 CA A:CYS176 4.9 132.7 1.0 C A:CYS176 4.9 132.7 1.0

Zinc binding site 2 out of 4 in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Lipid Nanodiscs, CLASS2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of the Human TRPC5 Ion Channel in Lipid Nanodiscs, CLASS2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn804 b:205.5 occ:1.00 ND1 B:HIS172 2.1 117.2 1.0 SG B:CYS181 2.3 128.5 1.0 SG B:CYS178 2.3 139.5 1.0 SG B:CYS176 2.3 132.2 1.0 CE1 B:HIS172 2.9 117.2 1.0 CG B:HIS172 3.2 117.2 1.0 CB B:CYS178 3.4 139.5 1.0 CB B:CYS181 3.5 128.5 1.0 CB B:CYS176 3.6 132.2 1.0 CB B:HIS172 3.7 117.2 1.0 NE2 B:HIS172 4.0 117.2 1.0 N B:CYS178 4.1 139.5 1.0 N B:CYS181 4.2 128.5 1.0 CD2 B:HIS172 4.2 117.2 1.0 CA B:CYS178 4.2 139.5 1.0 CA B:CYS181 4.4 128.5 1.0 OE1 B:GLU180 4.7 131.2 1.0 C B:CYS178 4.7 139.5 1.0 O B:CYS178 4.8 139.5 1.0 CA B:CYS176 4.9 132.2 1.0 C B:CYS176 4.9 132.2 1.0

Zinc binding site 3 out of 4 in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Lipid Nanodiscs, CLASS2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryo-Em Structure of the Human TRPC5 Ion Channel in Lipid Nanodiscs, CLASS2 within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn804 b:205.8 occ:1.00 ND1 C:HIS172 2.1 117.5 1.0 SG C:CYS181 2.3 128.3 1.0 SG C:CYS178 2.3 139.6 1.0 SG C:CYS176 2.3 133.1 1.0 CE1 C:HIS172 2.9 117.5 1.0 CG C:HIS172 3.2 117.5 1.0 CB C:CYS178 3.4 139.6 1.0 CB C:CYS181 3.5 128.3 1.0 CB C:CYS176 3.6 133.1 1.0 CB C:HIS172 3.7 117.5 1.0 NE2 C:HIS172 4.0 117.5 1.0 N C:CYS178 4.1 139.6 1.0 N C:CYS181 4.2 128.3 1.0 CD2 C:HIS172 4.2 117.5 1.0 CA C:CYS178 4.2 139.6 1.0 CA C:CYS181 4.4 128.3 1.0 OE1 C:GLU180 4.7 131.2 1.0 C C:CYS178 4.7 139.6 1.0 O C:CYS178 4.8 139.6 1.0 CA C:CYS176 4.9 133.1 1.0 C C:CYS176 4.9 133.1 1.0

Zinc binding site 4 out of 4 in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Lipid Nanodiscs, CLASS2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Cryo-Em Structure of the Human TRPC5 Ion Channel in Lipid Nanodiscs, CLASS2 within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn804 b:202.6 occ:1.00 ND1 D:HIS172 2.1 116.3 1.0 SG D:CYS181 2.3 127.1 1.0 SG D:CYS178 2.3 138.9 1.0 SG D:CYS176 2.3 132.4 1.0 CE1 D:HIS172 2.9 116.3 1.0 CG D:HIS172 3.2 116.3 1.0 CB D:CYS178 3.4 138.9 1.0 CB D:CYS181 3.5 127.1 1.0 CB D:CYS176 3.6 132.4 1.0 CB D:HIS172 3.7 116.3 1.0 NE2 D:HIS172 4.0 116.3 1.0 N D:CYS178 4.1 138.9 1.0 N D:CYS181 4.2 127.1 1.0 CD2 D:HIS172 4.2 116.3 1.0 CA D:CYS178 4.2 138.9 1.0 CA D:CYS181 4.4 127.1 1.0 OE1 D:GLU180 4.7 130.5 1.0 C D:CYS178 4.7 138.9 1.0 O D:CYS178 4.8 138.9 1.0 CA D:CYS176 4.9 132.4 1.0 C D:CYS176 4.9 132.4 1.0

J.Won, J.Kim, H.Jeong, J.Kim, S.Feng, B.Jeong, M.Kwak, J.Ko, W.Im, I.So, H.H.Lee. Molecular Architecture of the G Alpha I -Bound TRPC5 Ion Channel. Nat Commun V. 14 2550 2023.
ISSN: ESSN 2041-1723
PubMed: 37137991
DOI: 10.1038/S41467-023-38281-3