Zinc in PDB 8gq6: Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex
Enzymatic activity of Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex
All present enzymatic activity of Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex:
2.3.2.27;
2.3.2.32;
Zinc Binding Sites:
The binding sites of Zinc atom in the Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex
(pdb code 8gq6). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 6 binding sites of Zinc where determined in the
Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex, PDB code: 8gq6:
Jump to Zinc binding site number:
1;
2;
3;
4;
5;
6;
Zinc binding site 1 out
of 6 in 8gq6
Go back to
Zinc Binding Sites List in 8gq6
Zinc binding site 1 out
of 6 in the Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex
![](/pictures/ZN/pdb/gq/8gq6-ZN-sphere_01.jpg) Mono view
![](/pictures/ZN/pdb/gq/8gq6-ZN-sphere_01_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Zn4001
b:104.2
occ:1.00
|
ND1
|
E:HIS80
|
2.1
|
112.2
|
1.0
|
SG
|
E:CYS45
|
2.3
|
137.7
|
1.0
|
SG
|
E:CYS83
|
2.3
|
118.1
|
1.0
|
SG
|
E:CYS42
|
2.3
|
136.0
|
1.0
|
CE1
|
E:HIS80
|
2.8
|
112.3
|
1.0
|
CB
|
E:CYS42
|
3.0
|
136.2
|
1.0
|
CB
|
E:CYS45
|
3.0
|
137.7
|
1.0
|
CG
|
E:HIS80
|
3.2
|
112.4
|
1.0
|
CB
|
E:CYS83
|
3.6
|
117.6
|
1.0
|
CB
|
E:HIS80
|
3.7
|
112.5
|
1.0
|
N
|
E:CYS45
|
3.7
|
137.4
|
1.0
|
CA
|
E:CYS45
|
3.9
|
137.8
|
1.0
|
NE2
|
E:HIS80
|
4.0
|
112.3
|
1.0
|
CD2
|
E:HIS80
|
4.2
|
112.3
|
1.0
|
CB
|
E:CYS53
|
4.2
|
143.4
|
1.0
|
N
|
E:HIS80
|
4.3
|
112.2
|
1.0
|
CA
|
E:CYS42
|
4.5
|
136.3
|
1.0
|
C
|
E:CYS45
|
4.6
|
138.1
|
1.0
|
CA
|
E:HIS80
|
4.6
|
112.5
|
1.0
|
N
|
E:ARG46
|
4.6
|
138.5
|
1.0
|
O
|
E:HIS48
|
4.7
|
141.4
|
1.0
|
C
|
E:ILE44
|
4.8
|
137.0
|
1.0
|
CA
|
E:CYS53
|
4.9
|
143.5
|
1.0
|
CB
|
E:ILE44
|
4.9
|
136.6
|
1.0
|
|
Zinc binding site 2 out
of 6 in 8gq6
Go back to
Zinc Binding Sites List in 8gq6
Zinc binding site 2 out
of 6 in the Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex
![](/pictures/ZN/pdb/gq/8gq6-ZN-sphere_02.jpg) Mono view
![](/pictures/ZN/pdb/gq/8gq6-ZN-sphere_02_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Zn4002
b:92.5
occ:1.00
|
OD2
|
E:ASP97
|
2.1
|
131.3
|
1.0
|
SG
|
E:CYS75
|
2.3
|
115.9
|
1.0
|
ND1
|
E:HIS77
|
2.3
|
113.1
|
1.0
|
SG
|
E:CYS94
|
2.3
|
129.2
|
1.0
|
CB
|
E:CYS94
|
2.9
|
130.0
|
1.0
|
CG
|
E:ASP97
|
3.1
|
131.3
|
1.0
|
CE1
|
E:HIS77
|
3.2
|
113.2
|
1.0
|
CG
|
E:HIS77
|
3.3
|
112.9
|
1.0
|
OD1
|
E:ASP97
|
3.4
|
131.1
|
1.0
|
CB
|
E:CYS75
|
3.4
|
116.0
|
1.0
|
CB
|
E:HIS77
|
3.5
|
112.9
|
1.0
|
CE3
|
E:TRP101
|
4.3
|
129.1
|
1.0
|
NE2
|
E:HIS77
|
4.3
|
113.1
|
1.0
|
CA
|
E:CYS94
|
4.4
|
130.1
|
1.0
|
CD2
|
E:HIS77
|
4.4
|
113.0
|
1.0
|
CZ3
|
E:TRP101
|
4.4
|
128.8
|
1.0
|
CB
|
E:ASP97
|
4.4
|
131.3
|
1.0
|
CZ3
|
E:TRP35
|
4.5
|
160.4
|
1.0
|
CE3
|
E:TRP35
|
4.7
|
160.4
|
1.0
|
O
|
E:CYS75
|
4.7
|
115.6
|
1.0
|
CA
|
E:CYS75
|
4.7
|
116.0
|
1.0
|
C
|
E:CYS94
|
4.8
|
130.2
|
1.0
|
CA
|
E:HIS77
|
4.9
|
112.9
|
1.0
|
O
|
E:CYS94
|
4.9
|
130.2
|
1.0
|
N
|
E:ASP97
|
4.9
|
131.1
|
1.0
|
C
|
E:CYS75
|
5.0
|
115.6
|
1.0
|
N
|
E:HIS77
|
5.0
|
113.4
|
1.0
|
|
Zinc binding site 3 out
of 6 in 8gq6
Go back to
Zinc Binding Sites List in 8gq6
Zinc binding site 3 out
of 6 in the Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex
![](/pictures/ZN/pdb/gq/8gq6-ZN-sphere_03.jpg) Mono view
![](/pictures/ZN/pdb/gq/8gq6-ZN-sphere_03_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Zn4003
b:104.9
occ:1.00
|
ND1
|
E:HIS82
|
2.1
|
115.0
|
1.0
|
SG
|
E:CYS56
|
2.3
|
146.0
|
1.0
|
SG
|
E:CYS68
|
2.3
|
133.8
|
1.0
|
SG
|
E:CYS53
|
2.3
|
143.1
|
1.0
|
CE1
|
E:HIS82
|
2.8
|
114.9
|
1.0
|
CG
|
E:HIS82
|
3.0
|
115.1
|
1.0
|
CB
|
E:CYS56
|
3.1
|
146.0
|
1.0
|
NH1
|
C:ARG751
|
3.5
|
170.4
|
1.0
|
CB
|
E:HIS82
|
3.5
|
115.4
|
1.0
|
CB
|
E:CYS68
|
3.7
|
134.2
|
1.0
|
CB
|
E:CYS53
|
3.8
|
143.4
|
1.0
|
NE2
|
E:HIS82
|
3.9
|
114.7
|
1.0
|
CD2
|
E:HIS82
|
4.0
|
114.8
|
1.0
|
N
|
E:CYS53
|
4.2
|
143.3
|
1.0
|
CA
|
E:CYS56
|
4.3
|
146.0
|
1.0
|
N
|
E:CYS56
|
4.3
|
145.7
|
1.0
|
CA
|
E:CYS68
|
4.6
|
134.1
|
1.0
|
CA
|
E:CYS53
|
4.6
|
143.5
|
1.0
|
CZ
|
C:ARG751
|
4.8
|
170.4
|
1.0
|
C
|
E:GLU55
|
4.9
|
145.4
|
1.0
|
CA
|
E:HIS82
|
4.9
|
115.5
|
1.0
|
C
|
E:LEU52
|
5.0
|
143.2
|
1.0
|
|
Zinc binding site 4 out
of 6 in 8gq6
Go back to
Zinc Binding Sites List in 8gq6
Zinc binding site 4 out
of 6 in the Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex
![](/pictures/ZN/pdb/gq/8gq6-ZN-sphere_04.jpg) Mono view
![](/pictures/ZN/pdb/gq/8gq6-ZN-sphere_04_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Zn4001
b:104.2
occ:1.00
|
ND1
|
D:HIS80
|
2.1
|
112.2
|
1.0
|
CB
|
D:CYS42
|
2.2
|
136.2
|
1.0
|
SG
|
D:CYS45
|
2.3
|
137.7
|
1.0
|
SG
|
D:CYS83
|
2.3
|
118.1
|
1.0
|
SG
|
D:CYS42
|
2.3
|
136.0
|
1.0
|
CE1
|
D:HIS80
|
2.5
|
112.3
|
1.0
|
CB
|
D:CYS45
|
2.8
|
137.7
|
1.0
|
CG
|
D:HIS80
|
3.3
|
112.4
|
1.0
|
N
|
D:CYS45
|
3.4
|
137.4
|
1.0
|
NE2
|
D:HIS80
|
3.7
|
112.3
|
1.0
|
CA
|
D:CYS45
|
3.7
|
137.8
|
1.0
|
CB
|
D:CYS83
|
3.7
|
117.6
|
1.0
|
CA
|
D:CYS42
|
3.7
|
136.3
|
1.0
|
CD2
|
D:HIS80
|
4.1
|
112.3
|
1.0
|
CB
|
D:HIS80
|
4.1
|
112.5
|
1.0
|
N
|
D:HIS80
|
4.2
|
112.2
|
1.0
|
C
|
D:CYS42
|
4.3
|
136.2
|
1.0
|
C
|
D:CYS45
|
4.4
|
138.1
|
1.0
|
O
|
D:HIS48
|
4.4
|
141.4
|
1.0
|
N
|
D:ARG46
|
4.5
|
138.5
|
1.0
|
N
|
D:CYS42
|
4.5
|
136.5
|
1.0
|
C
|
D:ILE44
|
4.5
|
137.0
|
1.0
|
O
|
D:CYS42
|
4.6
|
136.3
|
1.0
|
CB
|
D:ILE44
|
4.7
|
136.6
|
1.0
|
CB
|
D:CYS53
|
4.7
|
143.4
|
1.0
|
N
|
D:ILE44
|
4.7
|
136.5
|
1.0
|
CA
|
D:HIS80
|
4.8
|
112.5
|
1.0
|
ND2
|
D:ASN47
|
4.9
|
139.8
|
1.0
|
CA
|
D:ILE44
|
4.9
|
136.8
|
1.0
|
|
Zinc binding site 5 out
of 6 in 8gq6
Go back to
Zinc Binding Sites List in 8gq6
Zinc binding site 5 out
of 6 in the Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex
![](/pictures/ZN/pdb/gq/8gq6-ZN-sphere_05.jpg) Mono view
![](/pictures/ZN/pdb/gq/8gq6-ZN-sphere_05_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 5 of Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Zn4002
b:92.5
occ:1.00
|
OD2
|
D:ASP97
|
2.1
|
131.3
|
1.0
|
SG
|
D:CYS94
|
2.3
|
129.2
|
1.0
|
ND1
|
D:HIS77
|
2.3
|
113.1
|
1.0
|
SG
|
D:CYS75
|
2.3
|
115.9
|
1.0
|
OD1
|
D:ASP97
|
2.6
|
131.1
|
1.0
|
CG
|
D:ASP97
|
2.7
|
131.3
|
1.0
|
CB
|
D:CYS75
|
2.7
|
116.0
|
1.0
|
CE1
|
D:HIS77
|
3.1
|
113.2
|
1.0
|
CG
|
D:HIS77
|
3.4
|
112.9
|
1.0
|
CB
|
D:CYS94
|
3.4
|
130.0
|
1.0
|
CB
|
D:HIS77
|
3.8
|
112.9
|
1.0
|
O
|
D:CYS75
|
3.9
|
115.6
|
1.0
|
CA
|
D:CYS75
|
4.1
|
116.0
|
1.0
|
CB
|
D:ASP97
|
4.1
|
131.3
|
1.0
|
NE2
|
D:HIS77
|
4.3
|
113.1
|
1.0
|
O
|
D:CYS94
|
4.3
|
130.2
|
1.0
|
C
|
D:CYS75
|
4.3
|
115.6
|
1.0
|
CD2
|
D:HIS77
|
4.4
|
113.0
|
1.0
|
N
|
D:ASP97
|
4.5
|
131.1
|
1.0
|
CA
|
D:CYS94
|
4.7
|
130.1
|
1.0
|
CB
|
D:ARG99
|
4.8
|
132.2
|
1.0
|
N
|
D:HIS77
|
4.8
|
113.4
|
1.0
|
C
|
D:CYS94
|
4.9
|
130.2
|
1.0
|
CB
|
D:LEU96
|
4.9
|
130.6
|
1.0
|
CG
|
D:ARG99
|
4.9
|
132.8
|
1.0
|
CA
|
D:ASP97
|
4.9
|
131.3
|
1.0
|
C
|
D:LEU96
|
4.9
|
130.8
|
1.0
|
CA
|
D:HIS77
|
4.9
|
112.9
|
1.0
|
N
|
D:CYS75
|
5.0
|
116.6
|
1.0
|
|
Zinc binding site 6 out
of 6 in 8gq6
Go back to
Zinc Binding Sites List in 8gq6
Zinc binding site 6 out
of 6 in the Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex
![](/pictures/ZN/pdb/gq/8gq6-ZN-sphere_06.jpg) Mono view
![](/pictures/ZN/pdb/gq/8gq6-ZN-sphere_06_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 6 of Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Zn4003
b:104.9
occ:1.00
|
ND1
|
D:HIS82
|
2.1
|
115.0
|
1.0
|
SG
|
D:CYS56
|
2.3
|
146.0
|
1.0
|
SG
|
D:CYS68
|
2.3
|
133.8
|
1.0
|
SG
|
D:CYS53
|
2.3
|
143.1
|
1.0
|
CG
|
D:HIS82
|
2.9
|
115.1
|
1.0
|
CE1
|
D:HIS82
|
3.0
|
114.9
|
1.0
|
CB
|
D:HIS82
|
3.2
|
115.4
|
1.0
|
NH1
|
F:ARG751
|
3.2
|
204.2
|
1.0
|
CB
|
D:CYS56
|
3.4
|
146.0
|
1.0
|
CB
|
D:CYS68
|
3.4
|
134.2
|
1.0
|
CB
|
D:CYS53
|
3.7
|
143.4
|
1.0
|
CD2
|
D:HIS82
|
3.9
|
114.8
|
1.0
|
NE2
|
D:HIS82
|
4.0
|
114.7
|
1.0
|
N
|
D:CYS56
|
4.3
|
145.7
|
1.0
|
CA
|
D:CYS56
|
4.3
|
146.0
|
1.0
|
N
|
D:CYS53
|
4.4
|
143.3
|
1.0
|
CZ
|
F:ARG751
|
4.5
|
204.2
|
1.0
|
CA
|
D:CYS68
|
4.6
|
134.1
|
1.0
|
C
|
D:GLU55
|
4.6
|
145.4
|
1.0
|
CA
|
D:CYS53
|
4.6
|
143.5
|
1.0
|
CA
|
D:HIS82
|
4.6
|
115.5
|
1.0
|
O
|
D:GLU55
|
4.9
|
145.5
|
1.0
|
|
Reference:
L.Sun,
Z.Chen,
Y.Hu,
Q.Mao.
Cryo-Em Structure of the KBTBD2-CUL3-RBX1 Dimeric Complex To Be Published.
Page generated: Thu Dec 28 13:05:38 2023
|