Zinc in PDB 8gis: Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.5MM MN2+

All present enzymatic activity of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.5MM MN2+:
2.7.7.86;

The structure of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.5MM MN2+, PDB code: 8gis was solved by S.Wu, J.Sohn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.54 / 2.46
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	78.056, 98.218, 142.465, 90, 90, 90
R / Rfree (%)	19.2 / 23

The structure of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.5MM MN2+ also contains other interesting chemical elements:

Manganese

(Mn)

4 atoms

The binding sites of Zinc atom in the Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.5MM MN2+ (pdb code 8gis). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.5MM MN2+, PDB code: 8gis:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.5MM MN2+


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.5MM MN2+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn602 b:42.2 occ:1.00 NE2 A:HIS378 2.1 37.2 1.0 SG A:CYS385 2.3 38.7 1.0 SG A:CYS384 2.3 38.1 1.0 SG A:CYS392 2.4 40.8 1.0 CD2 A:HIS378 2.9 36.1 1.0 CE1 A:HIS378 3.2 36.6 1.0 CB A:CYS385 3.2 36.2 1.0 CB A:CYS392 3.3 36.2 1.0 CB A:CYS384 3.7 34.0 1.0 N A:CYS385 3.7 38.5 1.0 N A:CYS392 3.7 39.0 1.0 C A:CYS384 3.7 37.8 1.0 O A:CYS384 4.0 35.3 1.0 CA A:CYS385 4.0 37.5 1.0 CA A:CYS392 4.0 39.1 1.0 CG A:HIS378 4.1 36.5 1.0 ND1 A:HIS378 4.2 37.5 1.0 CA A:CYS384 4.2 37.4 1.0 NH1 A:ARG394 4.5 35.5 1.0 C A:CYS392 4.6 41.9 1.0 O A:CYS392 4.7 41.7 1.0 C A:LYS391 4.8 41.3 1.0 O A:ALA390 4.9 41.3 1.0 O A:HOH716 4.9 38.4 1.0

Zinc binding site 2 out of 2 in the Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.5MM MN2+


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.5MM MN2+ within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn602 b:38.8 occ:1.00 NE2 C:HIS378 2.1 37.2 1.0 SG C:CYS385 2.3 42.5 1.0 SG C:CYS384 2.3 39.2 1.0 SG C:CYS392 2.3 40.5 1.0 CD2 C:HIS378 3.0 35.3 1.0 CE1 C:HIS378 3.2 36.1 1.0 CB C:CYS385 3.2 39.7 1.0 CB C:CYS392 3.3 39.7 1.0 O C:HOH715 3.5 41.0 1.0 CB C:CYS384 3.6 38.1 1.0 N C:CYS385 3.7 40.0 1.0 N C:CYS392 3.8 39.4 1.0 C C:CYS384 3.8 40.1 1.0 CA C:CYS385 4.0 41.5 1.0 CA C:CYS392 4.1 43.2 1.0 O C:CYS384 4.1 36.7 1.0 CG C:HIS378 4.2 36.3 1.0 CA C:CYS384 4.2 39.3 1.0 ND1 C:HIS378 4.2 37.2 1.0 NH1 C:ARG394 4.3 37.8 1.0 O C:CYS392 4.6 43.6 1.0 C C:CYS392 4.6 44.2 1.0 O C:ALA390 4.8 44.4 1.0 C C:LYS391 4.8 40.1 1.0

S.Wu, J.Sohn. Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Atp: with 10MM MG2+ and 0.5MM MN2+ To Be Published.