Zinc in PDB 8g66: Structure with SJ3149

All present enzymatic activity of Structure with SJ3149:
2.7.11.1;

The structure of Structure with SJ3149, PDB code: 8g66 was solved by D.J.Miller, S.M.Young, M.Fischer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.25 / 3.45
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	86.66, 109.71, 112.34, 105.49, 94.41, 100.03
R / Rfree (%)	21.3 / 27.2

The binding sites of Zinc atom in the Structure with SJ3149 (pdb code 8g66). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure with SJ3149, PDB code: 8g66:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure with SJ3149


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure with SJ3149 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn501 b:111.0 occ:1.00 SG B:CYS391 2.3 105.9 1.0 SG B:CYS394 2.3 107.3 1.0 SG B:CYS323 2.4 117.3 1.0 SG B:CYS326 2.4 109.7 1.0 CB B:CYS391 2.9 105.0 1.0 CB B:CYS394 3.3 112.5 1.0 CB B:CYS323 3.5 106.4 1.0 N B:CYS394 3.7 124.3 1.0 CB B:CYS326 3.7 110.9 1.0 N B:CYS326 4.0 113.3 1.0 CA B:CYS394 4.1 116.1 1.0 CA B:CYS391 4.3 102.8 1.0 CA B:CYS326 4.5 113.5 1.0 CB B:GLN325 4.5 108.4 1.0 C B:CYS391 4.7 104.7 1.0 C B:CYS394 4.7 114.5 1.0 CB B:ILE393 4.8 132.3 1.0 C B:ILE393 4.8 138.9 1.0 N B:ALA395 4.8 114.5 1.0 N B:ILE393 4.8 129.1 1.0 C B:GLN325 4.8 113.5 1.0 CB B:THR329 4.9 114.3 1.0 OG1 B:THR329 4.9 122.5 1.0 CA B:CYS323 4.9 105.8 1.0 O B:CYS391 4.9 110.8 1.0

Zinc binding site 2 out of 2 in the Structure with SJ3149


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure with SJ3149 within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn501 b:115.3 occ:1.00 SG E:CYS391 2.3 107.6 1.0 SG E:CYS326 2.3 127.7 1.0 SG E:CYS323 2.4 135.3 1.0 SG E:CYS394 2.4 116.2 1.0 CB E:CYS391 3.1 105.2 1.0 CB E:CYS323 3.2 129.9 1.0 CB E:CYS394 3.3 108.9 1.0 CB E:CYS326 3.6 129.1 1.0 N E:CYS394 4.0 109.2 1.0 N E:CYS326 4.1 127.2 1.0 CA E:CYS394 4.2 114.0 1.0 CB E:GLN325 4.4 125.6 1.0 CA E:CYS326 4.5 133.8 1.0 CA E:CYS391 4.5 103.1 1.0 CA E:CYS323 4.6 131.7 1.0 OG E:SER396 4.6 107.3 1.0 CB E:THR329 4.7 133.5 1.0 OG1 E:THR329 4.8 135.5 1.0 C E:CYS394 4.8 114.2 1.0 CD1 E:ILE398 4.9 106.2 1.0 C E:GLN325 4.9 127.5 1.0 C E:CYS391 4.9 103.3 1.0 CG2 E:THR329 5.0 124.8 1.0 CB E:SER396 5.0 107.6 1.0 N E:ALA395 5.0 112.7 1.0

D.J.Miller, S.M.Young, M.Fischer. Structure of Ternary Complex with Molecular Glue Targeting CK1A For Degradation By the CRL4CRBN Ubiquitin Ligase To Be Published.