Zinc in PDB 8fvj: Dimeric Form of Hiv-1 Vif in Complex with Human Cbf-Beta, Elob, Eloc, and CUL5

The binding sites of Zinc atom in the Dimeric Form of Hiv-1 Vif in Complex with Human Cbf-Beta, Elob, Eloc, and CUL5 (pdb code 8fvj). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Dimeric Form of Hiv-1 Vif in Complex with Human Cbf-Beta, Elob, Eloc, and CUL5, PDB code: 8fvj:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Dimeric Form of Hiv-1 Vif in Complex with Human Cbf-Beta, Elob, Eloc, and CUL5


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Dimeric Form of Hiv-1 Vif in Complex with Human Cbf-Beta, Elob, Eloc, and CUL5 within 5.0Å range: probe atom residue distance (Å) B Occ 1:Zn201 b:52.9 occ:1.00 NE2 1:HIS139 1.9 40.8 1.0 NE2 1:HIS108 2.0 42.2 1.0 SG 1:CYS114 2.3 45.0 1.0 SG 1:CYS133 2.3 43.6 1.0 CE1 1:HIS139 2.8 40.8 1.0 CD2 1:HIS139 2.9 40.8 1.0 CE1 1:HIS108 2.9 42.2 1.0 CD2 1:HIS108 3.0 42.2 1.0 CB 1:CYS114 3.5 45.0 1.0 CB 1:CYS133 3.5 43.6 1.0 O 1:ASP113 3.6 45.9 1.0 O 1:TYR135 3.8 43.2 1.0 ND1 1:HIS139 3.9 40.8 1.0 CA 1:CYS114 4.0 45.0 1.0 CG 1:HIS139 4.0 40.8 1.0 ND1 1:HIS108 4.0 42.2 1.0 CG 1:HIS108 4.1 42.2 1.0 C 1:ASP113 4.4 45.9 1.0 CA 1:CYS133 4.5 43.6 1.0 N 1:CYS114 4.6 45.0 1.0 C 1:TYR135 4.8 43.2 1.0 CG 0:ARG151 5.0 16.9 1.0

Zinc binding site 2 out of 2 in the Dimeric Form of Hiv-1 Vif in Complex with Human Cbf-Beta, Elob, Eloc, and CUL5


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Dimeric Form of Hiv-1 Vif in Complex with Human Cbf-Beta, Elob, Eloc, and CUL5 within 5.0Å range: probe atom residue distance (Å) B Occ 6:Zn201 b:52.7 occ:1.00 NE2 6:HIS139 1.9 40.9 1.0 NE2 6:HIS108 2.0 41.3 1.0 SG 6:CYS114 2.3 44.8 1.0 SG 6:CYS133 2.3 43.3 1.0 CE1 6:HIS139 2.8 40.9 1.0 CD2 6:HIS139 2.9 40.9 1.0 CE1 6:HIS108 2.9 41.3 1.0 CD2 6:HIS108 3.0 41.3 1.0 CB 6:CYS114 3.3 44.8 1.0 CB 6:CYS133 3.5 43.3 1.0 O 6:TYR135 3.9 42.6 1.0 ND1 6:HIS139 3.9 40.9 1.0 CG 6:HIS139 3.9 40.9 1.0 ND1 6:HIS108 4.0 41.3 1.0 CG 6:HIS108 4.1 41.3 1.0 CA 6:CYS114 4.2 44.8 1.0 CA 6:CYS133 4.5 43.3 1.0 C 6:TYR135 4.8 42.6 1.0 O 6:ASP113 4.8 45.5 1.0 CG 5:ARG151 4.9 13.2 1.0

F.Ito, A.L.Alvarez-Cabrera, K.Kim, Z.H.Zhou, X.S.Chen. Structural Basis of Hiv-1 Vif-Mediated E3 Ligase Targeting of Host APOBEC3H Nat Commun V. 14 5241 2023.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-023-40955-X