Zinc in PDB 8fjn: Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - C2221 Space Group

Enzymatic activity of Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - C2221 Space Group

All present enzymatic activity of Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - C2221 Space Group:
2.1.1.360;

Protein crystallography data

The structure of Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - C2221 Space Group, PDB code: 8fjn was solved by V.S.Frisbie, H.Hashimoto, E.W.Debler, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.49 / 2.10
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 57.842, 59.423, 169.947, 90, 90, 90
R / Rfree (%) 18.2 / 21

Other elements in 8fjn:

The structure of Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - C2221 Space Group also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - C2221 Space Group (pdb code 8fjn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - C2221 Space Group, PDB code: 8fjn:

Zinc binding site 1 out of 1 in 8fjn

Go back to Zinc Binding Sites List in 8fjn
Zinc binding site 1 out of 1 in the Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - C2221 Space Group


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - C2221 Space Group within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn302

b:29.3
occ:1.00
 SG A:CYS79 2.3 29.9 1.0
SG A:CYS77 2.3 36.8 1.0
SG A:CYS69 2.3 31.8 1.0
SG A:CYS72 2.3 30.5 1.0
HB2 A:CYS79 2.9 34.4 1.0
HB2 A:CYS77 3.0 44.5 1.0
HB2 A:CYS69 3.0 36.4 1.0
CB A:CYS69 3.1 30.2 1.0
HB3 A:CYS69 3.1 36.4 1.0
HB2 A:CYS72 3.2 42.3 1.0
CB A:CYS77 3.2 37.0 1.0
CB A:CYS79 3.2 28.6 1.0
H A:CYS72 3.3 41.0 1.0
CB A:CYS72 3.4 35.2 1.0
HB3 A:CYS77 3.4 44.5 1.0
H A:CYS79 3.5 37.9 1.0
HG22 A:THR115 3.7 36.3 1.0
HD21 A:ASN65 3.8 45.7 1.0
HB3 A:CYS79 3.8 34.4 1.0
HG A:SER118 4.0 40.4 1.0
N A:CYS72 4.0 34.1 1.0
HB2 A:HIS71 4.0 41.1 1.0
HB3 A:CYS72 4.1 42.3 1.0
N A:CYS79 4.2 31.5 1.0
CA A:CYS72 4.3 39.5 1.0
CA A:CYS79 4.3 28.8 1.0
HA A:THR115 4.4 30.6 1.0
HB2 A:SER118 4.4 32.9 1.0
H A:HIS71 4.4 46.1 1.0
O A:HOH455 4.5 34.0 1.0
ND2 A:ASN65 4.6 38.0 1.0
H A:HIS78 4.6 44.4 1.0
CA A:CYS69 4.6 34.8 1.0
HB3 A:SER118 4.6 32.9 1.0
CA A:CYS77 4.6 34.8 1.0
HA A:CYS72 4.7 47.5 1.0
OG A:SER118 4.7 33.6 1.0
CG2 A:THR115 4.7 30.2 1.0
CB A:SER118 4.8 27.3 1.0
HA A:CYS79 4.8 34.6 1.0
HD22 A:ASN65 4.8 45.7 1.0
HA A:CYS69 4.8 41.8 1.0
N A:HIS78 4.9 37.0 1.0
O A:HOH478 4.9 34.1 1.0
C A:CYS77 4.9 37.6 1.0
CB A:HIS71 4.9 34.1 1.0

Reference:

V.S.Frisbie, H.Hashimoto, Y.Xie, J.Baeza, T.Nguyen, Z.Yuan, B.A.Garcia, E.W.Debler. Structure and Mechanism of the Atypical Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase To Be Published.
Page generated: Wed Oct 30 20:26:51 2024

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