Zinc in PDB 8e6s: Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+

Other elements in 8e6s:

The structure of Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+ also contains other interesting chemical elements:

Calcium (Ca) 4 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+ (pdb code 8e6s). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+, PDB code: 8e6s:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 8e6s

Go back to Zinc Binding Sites List in 8e6s
Zinc binding site 1 out of 4 in the Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1603

b:876.2
occ:1.00
 NE2 A:HIS98 2.3 869.5 1.0
SG A:CYS91 2.3 790.0 1.0
SG A:CYS89 2.3 812.0 1.0
CB A:CYS89 2.4 812.0 1.0
CD2 A:HIS98 2.6 869.5 1.0
CB A:CYS91 2.7 790.0 1.0
CE1 A:HIS98 3.4 869.5 1.0
CB A:PHE75 3.4 807.1 1.0
CA A:PHE75 3.6 807.1 1.0
CG A:HIS98 3.7 869.5 1.0
N A:CYS91 3.9 790.0 1.0
CA A:CYS91 3.9 790.0 1.0
CA A:CYS89 3.9 812.0 1.0
ND1 A:HIS98 4.0 869.5 1.0
O A:TYR74 4.2 756.3 1.0
N A:PHE75 4.5 807.1 1.0
N A:VAL76 4.6 804.9 1.0
N A:CYS89 4.6 812.0 1.0
C A:CYS89 4.6 812.0 1.0
C A:TYR74 4.7 756.3 1.0
C A:PHE75 4.7 807.1 1.0
N A:GLN90 4.7 757.0 1.0
O A:TYR93 4.7 786.8 1.0
CB A:HIS98 4.8 869.5 1.0
C A:CYS91 4.8 790.0 1.0

Zinc binding site 2 out of 4 in 8e6s

Go back to Zinc Binding Sites List in 8e6s
Zinc binding site 2 out of 4 in the Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+ within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1603

b:876.0
occ:1.00
 NE2 B:HIS98 2.3 895.6 1.0
SG B:CYS91 2.3 805.7 1.0
SG B:CYS89 2.3 838.0 1.0
CB B:CYS89 2.4 838.0 1.0
CD2 B:HIS98 2.6 895.6 1.0
CB B:CYS91 2.7 805.7 1.0
CE1 B:HIS98 3.4 895.6 1.0
CB B:PHE75 3.4 833.5 1.0
CA B:PHE75 3.6 833.5 1.0
CG B:HIS98 3.7 895.6 1.0
N B:CYS91 3.9 805.7 1.0
CA B:CYS91 3.9 805.7 1.0
CA B:CYS89 3.9 838.0 1.0
ND1 B:HIS98 4.0 895.6 1.0
O B:TYR74 4.2 774.4 1.0
N B:PHE75 4.5 833.5 1.0
N B:VAL76 4.6 836.9 1.0
N B:CYS89 4.6 838.0 1.0
C B:CYS89 4.6 838.0 1.0
C B:TYR74 4.7 774.4 1.0
C B:PHE75 4.7 833.5 1.0
N B:GLN90 4.7 778.3 1.0
O B:TYR93 4.7 805.1 1.0
CB B:HIS98 4.8 895.6 1.0
C B:CYS91 4.8 805.7 1.0

Zinc binding site 3 out of 4 in 8e6s

Go back to Zinc Binding Sites List in 8e6s
Zinc binding site 3 out of 4 in the Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+ within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1603

b:906.6
occ:1.00
 NE2 C:HIS98 2.3 908.3 1.0
SG C:CYS91 2.3 829.9 1.0
SG C:CYS89 2.3 859.0 1.0
CB C:CYS89 2.4 859.0 1.0
CD2 C:HIS98 2.6 908.3 1.0
CB C:CYS91 2.7 829.9 1.0
CE1 C:HIS98 3.4 908.3 1.0
CB C:PHE75 3.4 829.4 1.0
CA C:PHE75 3.6 829.4 1.0
CG C:HIS98 3.7 908.3 1.0
N C:CYS91 3.9 829.9 1.0
CA C:CYS91 3.9 829.9 1.0
CA C:CYS89 3.9 859.0 1.0
ND1 C:HIS98 4.0 908.3 1.0
O C:TYR74 4.2 785.7 1.0
N C:PHE75 4.5 829.4 1.0
N C:VAL76 4.6 828.4 1.0
N C:CYS89 4.6 859.0 1.0
C C:CYS89 4.6 859.0 1.0
C C:TYR74 4.7 785.7 1.0
C C:PHE75 4.7 829.4 1.0
N C:GLN90 4.7 801.6 1.0
O C:TYR93 4.7 826.5 1.0
CB C:HIS98 4.8 908.3 1.0
C C:CYS91 4.8 829.9 1.0

Zinc binding site 4 out of 4 in 8e6s

Go back to Zinc Binding Sites List in 8e6s
Zinc binding site 4 out of 4 in the Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+ within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn1603

b:908.7
occ:1.00
 NE2 D:HIS98 2.3 912.2 1.0
SG D:CYS91 2.3 818.5 1.0
SG D:CYS89 2.3 841.9 1.0
CB D:CYS89 2.4 841.9 1.0
CD2 D:HIS98 2.6 912.2 1.0
CB D:CYS91 2.7 818.5 1.0
CE1 D:HIS98 3.4 912.2 1.0
CB D:PHE75 3.4 836.6 1.0
CA D:PHE75 3.6 836.6 1.0
CG D:HIS98 3.7 912.2 1.0
N D:CYS91 3.9 818.5 1.0
CA D:CYS91 3.9 818.5 1.0
CA D:CYS89 3.9 841.9 1.0
ND1 D:HIS98 4.0 912.2 1.0
O D:TYR74 4.2 787.7 1.0
N D:PHE75 4.5 836.6 1.0
N D:VAL76 4.6 829.6 1.0
N D:CYS89 4.6 841.9 1.0
C D:CYS89 4.6 841.9 1.0
C D:TYR74 4.7 787.7 1.0
C D:PHE75 4.7 836.6 1.0
N D:GLN90 4.7 778.8 1.0
O D:TYR93 4.7 812.3 1.0
CB D:HIS98 4.8 912.2 1.0
C D:CYS91 4.8 818.5 1.0

Reference:

L.Wang, T.-M.Fu. A Unified Mechanism For Human TRPM2 Activation, Desensitization and Inhibition To Be Published.
Page generated: Wed Oct 30 19:31:31 2024

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