Zinc in PDB 8d81: Cereblon~DDB1 Bound to Pomalidomide

The binding sites of Zinc atom in the Cereblon~DDB1 Bound to Pomalidomide (pdb code 8d81). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cereblon~DDB1 Bound to Pomalidomide, PDB code: 8d81:

Zinc binding site 1 out of 1 in the Cereblon~DDB1 Bound to Pomalidomide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cereblon~DDB1 Bound to Pomalidomide within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn501 b:0.0 occ:1.00 SG B:CYS394 2.3 0.0 1.0 SG B:CYS391 2.3 0.0 1.0 SG B:CYS326 2.3 0.0 1.0 SG B:CYS323 2.3 0.0 1.0 CB B:CYS394 3.2 0.0 1.0 CB B:CYS391 3.5 0.0 1.0 CB B:CYS326 3.6 0.0 1.0 N B:CYS394 3.6 0.0 1.0 CB B:CYS323 3.6 0.0 1.0 O B:CYS323 3.9 0.0 1.0 CA B:CYS394 4.0 0.0 1.0 N B:CYS326 4.5 0.0 1.0 N B:ALA395 4.5 0.0 1.0 C B:CYS394 4.6 0.0 1.0 CA B:CYS326 4.6 0.0 1.0 N B:ILE393 4.7 0.0 1.0 C B:CYS323 4.7 0.0 1.0 CA B:CYS323 4.8 0.0 1.0 C B:ILE393 4.8 0.0 1.0 CA B:CYS391 4.9 0.0 1.0 CD1 B:ILE398 5.0 0.0 1.0 N B:LYS392 5.0 0.0 1.0

E.R.Watson, S.J.Novick, M.E.Matyskiela, P.P.Chamberlain, A.H.De La Pena, J.Y.Zhu, E.Tran, P.R.Griffin, I.E.Wertz, G.C.Lander. Molecular Glue Celmod Compounds Are Allosteric Regulators of Cereblon Conformation Biorxiv 2022.
DOI: 10.1101/2022.07.02.498551