Atomistry » Zinc » PDB 8brv-8c8s » 8c0q
Atomistry »
  Zinc »
    PDB 8brv-8c8s »
      8c0q »

Zinc in PDB 8c0q: Crystal Structure of Human Carbonic Anhydrase II in Complex with A Coumarin Derivative.

Enzymatic activity of Crystal Structure of Human Carbonic Anhydrase II in Complex with A Coumarin Derivative.

All present enzymatic activity of Crystal Structure of Human Carbonic Anhydrase II in Complex with A Coumarin Derivative.:
4.2.1.1; 4.2.1.69;

Protein crystallography data

The structure of Crystal Structure of Human Carbonic Anhydrase II in Complex with A Coumarin Derivative., PDB code: 8c0q was solved by V.Alterio, G.De Simone, D.Esposito, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.40 / 1.67
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.271, 41.477, 72.164, 90, 104.38, 90
R / Rfree (%) 17.5 / 21.8

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Human Carbonic Anhydrase II in Complex with A Coumarin Derivative. (pdb code 8c0q). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human Carbonic Anhydrase II in Complex with A Coumarin Derivative., PDB code: 8c0q:

Zinc binding site 1 out of 1 in 8c0q

Go back to Zinc Binding Sites List in 8c0q
Zinc binding site 1 out of 1 in the Crystal Structure of Human Carbonic Anhydrase II in Complex with A Coumarin Derivative.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Carbonic Anhydrase II in Complex with A Coumarin Derivative. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:9.1
occ:1.00
N1 A:SWU302 2.0 10.7 1.0
NE2 A:HIS96 2.0 7.5 1.0
NE2 A:HIS94 2.0 7.9 1.0
ND1 A:HIS119 2.0 8.8 1.0
CE1 A:HIS119 2.9 9.2 1.0
CE1 A:HIS96 3.0 8.6 1.0
CD2 A:HIS94 3.0 7.2 1.0
CD2 A:HIS96 3.0 7.9 1.0
CE1 A:HIS94 3.0 9.2 1.0
S1 A:SWU302 3.1 10.6 1.0
CG A:HIS119 3.1 7.2 1.0
O1 A:SWU302 3.2 12.7 1.0
CB A:HIS119 3.6 4.3 1.0
C1 A:SWU302 3.8 13.2 1.0
OG1 A:THR199 3.9 6.8 1.0
OE1 A:GLU106 3.9 6.5 1.0
NE2 A:HIS119 4.1 7.7 1.0
ND1 A:HIS96 4.1 8.4 1.0
ND1 A:HIS94 4.2 8.4 1.0
CG A:HIS96 4.2 6.7 1.0
CG A:HIS94 4.2 7.1 1.0
CD2 A:HIS119 4.2 8.1 1.0
O2 A:SWU302 4.3 9.9 1.0
CD A:GLU106 4.9 8.8 1.0

Reference:

E.Langella, D.Esposito, S.M.Monti, C.T.Supuran, G.De Simone, V.Alterio. A Combined in Silico and Structural Study Opens New Perspectives on Aliphatic Sulfonamides, A Still Poorly Investigated Class of Ca Inhibitors. Biology (Basel) V. 12 2023.
ISSN: ESSN 2079-7737
PubMed: 36829558
DOI: 10.3390/BIOLOGY12020281
Page generated: Wed Oct 30 18:33:59 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy