Zinc in PDB 7zrp: 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex

Enzymatic activity of 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex

All present enzymatic activity of 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex:
2.7.11.17;

Protein crystallography data

The structure of 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex, PDB code: 7zrp was solved by N.Helassa, S.Antonyuk, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 53.24 / 2.65
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 64.283, 72.59, 78.156, 90, 90, 90
R / Rfree (%) 20.7 / 27.2

Other elements in 7zrp:

The structure of 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex also contains other interesting chemical elements:

Calcium (Ca) 8 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex (pdb code 7zrp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 9 binding sites of Zinc where determined in the 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex, PDB code: 7zrp:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;

Zinc binding site 1 out of 9 in 7zrp

Go back to Zinc Binding Sites List in 7zrp
Zinc binding site 1 out of 9 in the 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn208

b:84.9
occ:1.00
 OE1 A:GLU123 2.0 97.3 1.0
O A:HOH308 2.1 45.0 1.0
CD A:GLU123 3.0 87.5 1.0
OE2 A:GLU123 3.5 86.8 1.0
CG A:GLU123 4.2 81.0 1.0
O A:HOH313 4.3 56.0 1.0
HG3 A:GLU123 4.3 81.3 1.0
HG2 A:GLU123 4.5 81.3 1.0
HB3 A:GLU119 4.8 91.2 1.0
HB3 B:PHE1 4.9 85.3 1.0

Zinc binding site 2 out of 9 in 7zrp

Go back to Zinc Binding Sites List in 7zrp
Zinc binding site 2 out of 9 in the 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn209

b:98.0
occ:1.00
 OE1 C:GLU54 2.0 104.5 1.0
OE1 A:GLU83 2.0 84.4 1.0
O A:HOH312 2.9 40.1 1.0
CD A:GLU83 2.9 81.6 1.0
CD C:GLU54 3.0 94.4 1.0
OE2 A:GLU83 3.2 83.9 1.0
OE2 C:GLU54 3.3 109.2 1.0
HA C:MET51 3.8 61.1 1.0
HG2 C:MET51 3.8 64.3 1.0
O D:ASN21 4.0 53.6 1.0
HB3 D:SER23 4.1 59.7 1.0
CG C:GLU54 4.3 77.0 1.0
HB2 C:GLU54 4.3 71.1 1.0
CG A:GLU83 4.3 71.0 1.0
HB3 D:ASN21 4.3 68.0 1.0
HG2 A:GLU83 4.4 70.5 1.0
HB2 D:ASN21 4.6 68.0 1.0
HG3 C:GLU54 4.6 79.0 1.0
CB C:GLU54 4.7 69.8 1.0
HB3 C:GLU54 4.7 71.2 1.0
HB2 A:GLU83 4.7 61.6 1.0
HD3 A:ARG86 4.7 72.0 1.0
CG C:MET51 4.8 66.7 1.0
CA C:MET51 4.8 60.0 1.0
HH22 A:ARG90 4.8 81.8 1.0
CB D:ASN21 4.9 66.5 1.0
HG3 A:GLU83 4.9 70.5 1.0
HG2 C:GLU54 5.0 79.0 1.0
CB D:SER23 5.0 60.2 1.0

Zinc binding site 3 out of 9 in 7zrp

Go back to Zinc Binding Sites List in 7zrp
Zinc binding site 3 out of 9 in the 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn210

b:91.2
occ:1.00
 OE2 A:GLU54 2.0 99.8 1.0
OE1 C:GLU83 2.0 105.8 1.0
OE2 C:GLU83 2.0 93.7 1.0
CD C:GLU83 2.3 95.4 1.0
CD A:GLU54 2.9 120.6 1.0
OE1 A:GLU54 3.2 124.1 1.0
O C:HOH315 3.2 45.6 1.0
HH11 C:ARG86 3.4 123.4 0.0
HD2 C:ARG86 3.8 92.2 1.0
CG C:GLU83 3.8 86.3 1.0
HA A:MET51 3.9 60.4 1.0
HG2 A:MET51 4.0 67.5 1.0
NH1 C:ARG86 4.1 122.9 1.0
HB3 B:ASN20 4.1 64.3 1.0
O B:ASN20 4.1 51.5 1.0
HG2 C:GLU83 4.1 86.9 1.0
HH12 C:ARG86 4.2 123.4 0.0
HG3 C:GLU83 4.2 86.7 1.0
HB2 B:ASN20 4.3 64.3 1.0
CG A:GLU54 4.3 109.7 1.0
HG3 A:MET51 4.3 67.5 1.0
HG2 A:GLU54 4.5 106.5 1.0
HB3 A:GLU54 4.5 90.8 1.0
HB3 B:SER22 4.6 68.9 1.0
HD3 C:ARG86 4.6 92.2 1.0
HA C:GLU83 4.6 68.3 1.0
CG A:MET51 4.6 68.3 1.0
CD C:ARG86 4.6 90.9 1.0
O B:HOH103 4.6 50.3 1.0
CB B:ASN20 4.7 63.9 1.0
HB2 C:GLU83 4.7 78.4 1.0
CB C:GLU83 4.8 80.5 1.0
CA A:MET51 4.8 61.0 1.0
CB A:GLU54 4.9 89.5 1.0
HB2 C:ARG86 4.9 75.2 1.0
HB3 A:ASP50 4.9 77.6 1.0
HG3 A:GLU54 4.9 106.7 1.0
HB2 A:GLU54 5.0 90.8 1.0

Zinc binding site 4 out of 9 in 7zrp

Go back to Zinc Binding Sites List in 7zrp
Zinc binding site 4 out of 9 in the 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn211

b:86.9
occ:0.50
 OD2 A:ASP122 2.0 85.9 1.0
CG A:ASP122 3.0 73.2 1.0
HB3 A:ASP118 3.3 77.8 1.0
OD1 A:ASP122 3.3 73.2 1.0
O A:ASP118 3.8 82.2 1.0
CB A:ASP118 4.3 80.0 1.0
CB A:ASP122 4.4 62.9 1.0
HB2 A:ASP122 4.4 63.2 1.0
C A:ASP118 4.5 77.4 1.0
HB2 A:ASP118 4.6 77.8 1.0
HB3 A:ASP122 4.8 63.2 1.0
CA A:ASP118 4.9 78.3 1.0

Zinc binding site 5 out of 9 in 7zrp

Go back to Zinc Binding Sites List in 7zrp
Zinc binding site 5 out of 9 in the 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn212

b:64.2
occ:1.00
 OD2 C:ASP80 2.1 82.0 1.0
OD1 A:ASP78 2.1 67.7 1.0
OE2 A:GLU84 2.1 71.6 1.0
OD2 A:ASP78 2.1 51.9 1.0
OE1 A:GLU84 2.1 71.7 1.0
OD1 C:ASP80 2.2 70.4 1.0
O C:HOH308 2.2 28.5 1.0
CG A:ASP78 2.3 68.9 1.0
CG C:ASP80 2.4 69.2 1.0
CD A:GLU84 2.5 61.8 1.0
O A:HOH301 2.7 37.9 1.0
HB2 A:ASP80 3.4 69.9 1.0
HZ2 A:LYS75 3.5 97.7 1.0
HG2 B:ARG19 3.8 85.2 1.0
CB A:ASP78 3.8 71.6 1.0
CB C:ASP80 3.9 74.4 1.0
O B:HOH101 4.0 50.6 1.0
CG A:GLU84 4.0 60.4 1.0
HB3 A:ASP78 4.1 71.2 1.0
HB2 A:ASP78 4.1 71.2 1.0
HG3 A:LYS75 4.2 90.0 1.0
HB3 C:ASP80 4.2 73.0 1.0
NZ A:LYS75 4.3 98.7 1.0
HG2 A:GLU84 4.3 59.6 1.0
HZ3 A:LYS75 4.3 97.7 1.0
HG3 A:GLU84 4.3 59.7 1.0
HB2 C:ASP80 4.3 73.0 1.0
CB A:ASP80 4.4 69.5 1.0
H A:ASP80 4.4 76.0 1.0
OXT B:SER22 4.5 76.5 1.0
OD2 A:ASP80 4.5 68.1 1.0
HG3 B:ARG19 4.6 85.1 1.0
HH22 D:ARG20 4.6 93.5 1.0
HG B:SER22 4.6 66.3 0.0
CG B:ARG19 4.6 83.3 1.0
HZ1 A:LYS75 4.7 97.7 1.0
HH11 B:ARG19 4.7 107.6 0.0
O A:ASP80 4.8 78.5 1.0
O B:SER22 4.8 63.6 1.0
HA A:ASP78 4.8 73.7 1.0
HB3 A:ASP80 4.8 69.8 1.0
HB2 A:GLU84 4.9 55.7 1.0
CG A:ASP80 4.9 67.7 1.0
CA A:ASP78 4.9 72.6 1.0
C A:ASP80 4.9 73.8 1.0
C B:SER22 4.9 69.0 1.0
HA A:LYS75 5.0 93.1 1.0
CA C:ASP80 5.0 74.2 1.0
HA C:ASP80 5.0 74.6 1.0

Zinc binding site 6 out of 9 in 7zrp

Go back to Zinc Binding Sites List in 7zrp
Zinc binding site 6 out of 9 in the 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn206

b:62.2
occ:1.00
 OE2 C:GLU120 2.1 60.5 1.0
OE1 C:GLU120 2.1 53.6 1.0
CD C:GLU120 2.4 48.6 1.0
O C:HOH309 2.6 50.2 1.0
HD1 D:PHE2 3.8 61.4 1.0
O C:HOH311 3.9 66.5 1.0
CG C:GLU120 4.0 46.7 1.0
HG22 C:THR117 4.1 53.6 1.0
HG2 C:GLU120 4.3 47.9 1.0
HG3 C:GLU120 4.3 47.8 1.0
HB2 D:PHE2 4.3 63.9 1.0
CD1 D:PHE2 4.4 62.5 1.0
H C:THR117 4.8 65.0 1.0
HG1 C:THR117 4.8 52.5 0.0
HE1 D:PHE2 4.9 60.4 1.0
CE1 D:PHE2 5.0 58.9 1.0

Zinc binding site 7 out of 9 in 7zrp

Go back to Zinc Binding Sites List in 7zrp
Zinc binding site 7 out of 9 in the 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn207

b:79.7
occ:1.00
 OD1 C:ASP50 2.1 75.2 1.0
CG C:ASP50 3.2 77.8 1.0
HD21 C:ASN53 3.5 67.3 0.0
OD2 C:ASP50 3.8 76.6 1.0
HA C:ASP50 4.0 73.7 1.0
ND2 C:ASN53 4.2 66.8 1.0
HD22 C:ASN53 4.3 67.3 0.0
CB C:ASP50 4.4 77.2 1.0
CA C:ASP50 4.6 73.8 1.0
HB3 C:ASP50 4.7 76.5 1.0

Zinc binding site 8 out of 9 in 7zrp

Go back to Zinc Binding Sites List in 7zrp
Zinc binding site 8 out of 9 in the 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn208

b:76.2
occ:1.00
 HZ1 D:LYS7 1.7 62.9 0.0
HZ2 D:LYS7 1.8 62.9 0.0
OE2 C:GLU14 2.0 62.9 1.0
OE2 C:GLU114 2.0 83.3 1.0
NZ D:LYS7 2.1 62.7 1.0
HZ3 D:LYS7 2.6 62.9 0.0
CD C:GLU14 2.9 63.4 1.0
HD3 D:LYS7 3.0 57.1 1.0
CD C:GLU114 3.1 77.3 1.0
OE1 C:GLU14 3.2 60.1 1.0
CE D:LYS7 3.3 56.5 1.0
CD D:LYS7 3.5 56.6 1.0
HD21 C:LEU18 3.5 41.5 1.0
HD2 D:LYS7 3.6 57.0 1.0
HG2 C:GLU114 3.6 76.4 1.0
HG C:SER17 3.6 58.9 0.0
CG C:GLU114 3.8 77.2 1.0
HE2 D:LYS7 3.8 57.9 1.0
HE3 D:LYS7 3.9 57.9 1.0
HG C:LEU18 3.9 43.2 1.0
OE1 C:GLU114 4.0 76.3 1.0
HG3 C:GLU114 4.0 76.4 1.0
HD23 C:LEU18 4.1 41.5 1.0
OG C:SER17 4.2 59.5 1.0
CD2 C:LEU18 4.2 40.5 1.0
CG C:GLU14 4.3 63.7 1.0
HG3 C:GLU14 4.4 62.8 1.0
CG C:LEU18 4.6 43.7 1.0
HG2 C:GLU14 4.6 62.8 1.0
HD11 C:LEU18 4.7 42.7 1.0
HA D:LYS7 4.8 56.0 1.0
CG D:LYS7 4.9 58.4 1.0
HA C:GLU14 5.0 59.5 1.0
O C:GLU14 5.0 58.3 1.0

Zinc binding site 9 out of 9 in 7zrp

Go back to Zinc Binding Sites List in 7zrp
Zinc binding site 9 out of 9 in the 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of 2.65 Angstrom Crystal Structure of Ca/Cam:Camkiidelta Peptide Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn209

b:58.9
occ:1.00
 OE2 C:GLU84 2.0 53.1 1.0
OD2 A:ASP80 2.0 68.1 1.0
OD2 C:ASP78 2.1 72.7 1.0
OD1 A:ASP80 2.1 63.3 1.0
OD1 C:ASP78 2.1 74.0 1.0
O D:HOH101 2.2 36.6 1.0
CG A:ASP80 2.3 67.7 1.0
CG C:ASP78 2.4 72.1 1.0
CD C:GLU84 2.8 58.0 1.0
OE1 C:GLU84 3.1 64.7 1.0
HB2 C:ASP80 3.4 73.0 1.0
HZ2 C:LYS75 3.4 91.1 1.0
CB A:ASP80 3.8 69.5 1.0
CB C:ASP78 3.8 72.8 1.0
HB3 A:ASP80 4.0 69.8 1.0
HE D:ARG20 4.0 84.0 1.0
HZ3 C:LYS75 4.0 91.1 1.0
NZ C:LYS75 4.1 91.2 1.0
HB3 C:ASP78 4.1 72.3 1.0
HB2 C:ASP78 4.2 72.3 1.0
HG3 D:ARG20 4.2 72.7 1.0
HB2 A:ASP80 4.2 69.9 1.0
CG C:GLU84 4.2 54.6 1.0
CB C:ASP80 4.4 74.4 1.0
OXT D:SER23 4.4 75.2 1.0
HG3 C:LYS75 4.4 84.8 1.0
HG3 C:GLU84 4.4 55.3 1.0
H C:ASP80 4.4 74.0 1.0
HZ1 C:LYS75 4.5 91.1 1.0
HG2 C:GLU84 4.5 55.3 1.0
OD2 C:ASP80 4.6 82.0 1.0
NE D:ARG20 4.7 82.7 1.0
HB3 C:ASP80 4.8 73.0 1.0
HG D:SER23 4.8 57.4 0.0
O C:HOH307 4.8 45.5 1.0
O D:SER23 4.8 58.9 1.0
HA C:ASP78 4.9 72.3 1.0
CA A:ASP80 4.9 72.7 1.0
HA A:ASP80 4.9 73.2 1.0
O C:ASP80 4.9 64.4 1.0
CG C:ASP80 4.9 69.2 1.0
C D:SER23 4.9 67.1 1.0
CA C:ASP78 5.0 71.3 1.0

Reference:

O.Prakash, N.Gupta, A.Milburn, L.Mccormick, V.Deugi, P.Fisch, J.Wyles, N.L.Thomas, S.Antonyuk, C.Dart, N.Helassa. Calmodulin Variant E140G Associated with Long Qt Syndrome Impairs Camkii Delta Autophosphorylation and L-Type Calcium Channel (Ca V 1.2) Inactivation. J.Biol.Chem. 02777 2022.
ISSN: ESSN 1083-351X
PubMed: 36496072
DOI: 10.1016/J.JBC.2022.102777
Page generated: Wed Oct 30 17:17:03 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy