Zinc in PDB 7zo2: L1 Metallo-Beta-Lactamase Complex with Hydrolysed Doripenem

All present enzymatic activity of L1 Metallo-Beta-Lactamase Complex with Hydrolysed Doripenem:
3.5.2.6;

The structure of L1 Metallo-Beta-Lactamase Complex with Hydrolysed Doripenem, PDB code: 7zo2 was solved by P.Hinchliffe, J.Spencer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	66.86 / 1.49
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	105.435, 105.435, 98.181, 90, 90, 120
R / Rfree (%)	17.6 / 20.5

The structure of L1 Metallo-Beta-Lactamase Complex with Hydrolysed Doripenem also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Zinc atom in the L1 Metallo-Beta-Lactamase Complex with Hydrolysed Doripenem (pdb code 7zo2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the L1 Metallo-Beta-Lactamase Complex with Hydrolysed Doripenem, PDB code: 7zo2:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the L1 Metallo-Beta-Lactamase Complex with Hydrolysed Doripenem


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of L1 Metallo-Beta-Lactamase Complex with Hydrolysed Doripenem within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:32.9 occ:1.00 OD2 A:ASP88 2.1 34.6 1.0 NAN A:DQM305 2.1 95.7 1.0 NE2 A:HIS89 2.2 33.1 1.0 NE2 A:HIS225 2.2 32.8 1.0 OAX A:DQM305 2.3 39.5 1.0 OAH A:DQM305 2.4 31.6 1.0 CAS A:DQM305 2.8 56.8 1.0 CG A:ASP88 2.9 33.0 1.0 CAR A:DQM305 3.0 54.5 1.0 CE1 A:HIS89 3.1 29.9 1.0 CD2 A:HIS225 3.1 36.0 1.0 CD2 A:HIS89 3.1 28.1 1.0 OD1 A:ASP88 3.2 27.7 1.0 CAJ A:DQM305 3.2 62.2 1.0 HD2 A:HIS225 3.2 43.2 1.0 HE1 A:HIS89 3.2 35.9 1.0 CE1 A:HIS225 3.2 30.0 1.0 CAY A:DQM305 3.3 98.7 1.0 HD2 A:HIS89 3.3 33.7 1.0 HE1 A:HIS225 3.5 36.0 1.0 H8 A:DQM305 3.6 118.6 1.0 CAX A:DQM305 3.7 53.2 1.0 H3 A:DQM305 3.7 102.0 1.0 ZN A:ZN302 3.8 29.6 1.0 HE1 A:HIS84 3.9 34.5 1.0 HG A:SER185 4.0 37.9 1.0 ND1 A:HIS89 4.2 30.4 1.0 CAT A:DQM305 4.2 84.8 1.0 CG A:HIS89 4.2 29.0 1.0 OAE A:DQM305 4.2 38.4 1.0 CB A:ASP88 4.3 29.1 1.0 CAZ A:DQM305 4.3 53.6 1.0 CG A:HIS225 4.3 35.0 1.0 HB2 A:ASP88 4.3 35.0 1.0 ND1 A:HIS225 4.3 29.9 1.0 OAD A:DQM305 4.3 43.6 1.0 NE2 A:HIS84 4.4 28.0 1.0 CE1 A:HIS84 4.5 28.8 1.0 CAU A:DQM305 4.5 66.9 1.0 H2 A:DQM305 4.6 64.1 1.0 H17 A:DQM305 4.6 62.9 1.0 HH2 A:TRP17 4.7 39.0 1.0 H14 A:DQM305 4.7 64.5 1.0 H16 A:DQM305 4.7 62.9 1.0 OG A:SER185 4.7 31.6 1.0 HZ3 A:TRP17 4.8 41.9 1.0 HB3 A:ASP88 4.8 35.0 1.0 HD21 A:LEU38 4.9 38.4 1.0 H9 A:DQM305 4.9 80.5 1.0 HB2 A:PRO224 4.9 37.1 1.0 HB2 A:HIS86 4.9 33.4 1.0 HD1 A:HIS89 4.9 36.5 1.0

Zinc binding site 2 out of 2 in the L1 Metallo-Beta-Lactamase Complex with Hydrolysed Doripenem


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of L1 Metallo-Beta-Lactamase Complex with Hydrolysed Doripenem within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:29.6 occ:1.00 OAX A:DQM305 1.9 39.5 1.0 NE2 A:HIS160 2.1 28.0 1.0 NE2 A:HIS84 2.2 28.0 1.0 ND1 A:HIS86 2.2 28.0 1.0 CAJ A:DQM305 2.5 62.2 1.0 OAD A:DQM305 2.6 43.6 1.0 CD2 A:HIS160 3.0 27.8 1.0 HB2 A:HIS86 3.0 33.4 1.0 CD2 A:HIS84 3.0 29.2 1.0 HD2 A:HIS160 3.1 33.4 1.0 CE1 A:HIS84 3.1 28.8 1.0 CE1 A:HIS86 3.1 28.7 1.0 CG A:HIS86 3.1 24.6 1.0 HD2 A:HIS84 3.2 35.0 1.0 CE1 A:HIS160 3.2 28.4 1.0 HE1 A:HIS86 3.3 34.4 1.0 HE1 A:HIS84 3.3 34.5 1.0 HE1 A:HIS160 3.4 34.0 1.0 CB A:HIS86 3.5 27.9 1.0 OAH A:DQM305 3.5 31.6 1.0 HD2 A:HIS89 3.5 33.7 1.0 HB3 A:HIS86 3.6 33.4 1.0 ZN A:ZN301 3.8 32.9 1.0 H6 A:DQM305 4.0 95.4 1.0 CAX A:DQM305 4.1 53.2 1.0 CG A:HIS84 4.1 27.2 1.0 ND1 A:HIS84 4.1 29.6 1.0 CG A:HIS160 4.1 28.9 1.0 CD2 A:HIS89 4.2 28.1 1.0 CAR A:DQM305 4.2 54.5 1.0 ND1 A:HIS160 4.2 28.1 1.0 HE2 A:PHE124 4.2 50.4 1.0 NE2 A:HIS86 4.2 29.3 1.0 CD2 A:HIS86 4.3 26.2 1.0 OD1 A:ASP88 4.3 27.7 1.0 NE2 A:HIS89 4.4 33.1 1.0 HG23 A:THR161 4.4 34.9 1.0 HG A:SER185 4.4 37.9 1.0 NAN A:DQM305 4.5 95.7 1.0 H2 A:DQM305 4.5 64.1 1.0 CAS A:DQM305 4.5 56.8 1.0 H3 A:DQM305 4.6 102.0 1.0 CAT A:DQM305 4.7 84.8 1.0 CAA A:DQM305 4.8 79.4 1.0 HB2 A:SER185 4.8 36.0 1.0 HZ A:PHE124 4.8 46.3 1.0 HD1 A:HIS84 4.9 35.5 1.0 H A:HIS86 4.9 29.9 1.0 CA A:HIS86 4.9 25.2 1.0 CAY A:DQM305 4.9 98.7 1.0 H14 A:DQM305 5.0 64.5 1.0

P.Hinchliffe, J.Spencer. L1 Metallo-Beta-Lactamase Complex with Hydrolysed Doripenem To Be Published.