Zinc in PDB 7ziu: Crystal Structure of Ntaya Virus NS5 Polymerase Domain

The structure of Crystal Structure of Ntaya Virus NS5 Polymerase Domain, PDB code: 7ziu was solved by K.Krejcova, M.Klima, E.Boura, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.58 / 2.80
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	64.285, 79.793, 133.255, 90, 93.31, 90
R / Rfree (%)	23.7 / 28.9

The binding sites of Zinc atom in the Crystal Structure of Ntaya Virus NS5 Polymerase Domain (pdb code 7ziu). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Ntaya Virus NS5 Polymerase Domain, PDB code: 7ziu:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Crystal Structure of Ntaya Virus NS5 Polymerase Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Ntaya Virus NS5 Polymerase Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:53.1 occ:1.00 OE2 A:GLU440 2.1 49.7 1.0 SG A:CYS452 2.3 51.6 1.0 SG A:CYS449 2.3 62.0 1.0 NE2 A:HIS444 2.3 52.3 1.0 CB A:CYS452 3.2 48.3 1.0 CD A:GLU440 3.2 60.0 1.0 CE1 A:HIS444 3.2 59.7 1.0 CB A:CYS449 3.3 49.5 1.0 CD2 A:HIS444 3.3 52.5 1.0 N A:CYS452 3.6 51.2 1.0 CG A:GLU440 3.6 60.2 1.0 CA A:CYS449 3.6 45.2 1.0 N A:GLU450 3.9 62.4 1.0 CA A:CYS452 4.0 46.4 1.0 C A:CYS449 4.2 49.8 1.0 N A:MET451 4.2 52.2 1.0 OE1 A:GLU440 4.3 60.3 1.0 ND1 A:HIS444 4.4 56.0 1.0 CG A:HIS444 4.4 52.1 1.0 C A:MET451 4.6 52.8 1.0 O A:ARG448 4.9 54.6 1.0 CA A:MET451 4.9 60.5 1.0 N A:CYS449 5.0 64.3 1.0 C A:GLU450 5.0 59.7 1.0 CA A:GLU450 5.0 65.2 1.0 O A:GLU440 5.0 60.5 1.0

Zinc binding site 2 out of 4 in the Crystal Structure of Ntaya Virus NS5 Polymerase Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Ntaya Virus NS5 Polymerase Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1002 b:44.4 occ:1.00 NE2 A:HIS719 2.0 36.7 1.0 NE2 A:HIS717 2.1 54.6 1.0 SG A:CYS733 2.3 35.6 1.0 SG A:CYS852 2.3 47.1 1.0 CD2 A:HIS719 2.8 34.2 1.0 CD2 A:HIS717 3.0 45.3 1.0 CE1 A:HIS717 3.1 57.3 1.0 CE1 A:HIS719 3.2 37.3 1.0 CB A:CYS733 3.2 47.9 1.0 CB A:CYS852 3.5 52.1 1.0 CG A:HIS719 4.0 37.2 1.0 CG A:HIS717 4.2 51.9 1.0 ND1 A:HIS717 4.2 55.1 1.0 ND1 A:HIS719 4.2 31.9 1.0 CD1 A:LEU844 4.2 36.9 1.0 CA A:CYS733 4.5 47.9 1.0 C A:CYS733 4.5 50.3 1.0 O A:GLU848 4.6 47.8 1.0 N A:ARG734 4.7 54.3 1.0 CA A:CYS852 4.9 44.0 1.0 O A:CYS733 4.9 53.3 1.0

Zinc binding site 3 out of 4 in the Crystal Structure of Ntaya Virus NS5 Polymerase Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Ntaya Virus NS5 Polymerase Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1001 b:57.5 occ:1.00 OE2 B:GLU440 2.0 54.3 1.0 NE2 B:HIS444 2.3 37.9 1.0 SG B:CYS449 2.3 47.4 1.0 SG B:CYS452 2.3 54.2 1.0 CB B:CYS452 3.0 47.2 1.0 CD B:GLU440 3.1 56.3 1.0 CD2 B:HIS444 3.2 43.6 1.0 CB B:CYS449 3.3 56.7 1.0 CE1 B:HIS444 3.3 44.5 1.0 CG B:GLU440 3.6 55.2 1.0 N B:CYS452 3.6 58.9 1.0 CA B:CYS449 3.6 49.8 1.0 N B:GLU450 3.9 58.1 1.0 CA B:CYS452 3.9 49.6 1.0 C B:CYS449 4.1 55.2 1.0 OE1 B:GLU440 4.2 59.7 1.0 N B:MET451 4.2 56.8 1.0 CG B:HIS444 4.4 44.5 1.0 ND1 B:HIS444 4.4 42.8 1.0 C B:MET451 4.6 57.5 1.0 O B:ARG448 4.9 57.2 1.0 N B:CYS449 4.9 61.1 1.0 CA B:MET451 5.0 59.2 1.0 CA B:GLU450 5.0 52.0 1.0

Zinc binding site 4 out of 4 in the Crystal Structure of Ntaya Virus NS5 Polymerase Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Ntaya Virus NS5 Polymerase Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1002 b:42.4 occ:1.00 NE2 B:HIS719 2.0 41.8 1.0 NE2 B:HIS717 2.0 47.0 1.0 SG B:CYS852 2.3 46.8 1.0 SG B:CYS733 2.3 37.6 1.0 CD2 B:HIS719 2.8 36.3 1.0 CD2 B:HIS717 2.9 38.8 1.0 CE1 B:HIS717 3.1 44.3 1.0 CE1 B:HIS719 3.2 46.0 1.0 CB B:CYS733 3.3 39.0 1.0 CB B:CYS852 3.5 49.8 1.0 CD1 B:LEU844 4.0 53.3 1.0 CG B:HIS719 4.1 34.6 1.0 CG B:HIS717 4.1 44.5 1.0 ND1 B:HIS719 4.2 39.3 1.0 ND1 B:HIS717 4.2 43.7 1.0 CA B:CYS733 4.6 41.3 1.0 C B:CYS733 4.7 41.8 1.0 N B:ARG734 4.8 41.5 1.0 CA B:CYS852 4.9 46.8 1.0 NH1 B:ARG774 4.9 45.2 1.0 O B:ARG734 4.9 48.3 1.0 O B:GLU848 4.9 49.6 1.0

K.Krejcova, M.Klima, E.Boura. Crystal Structure of Ntaya Virus NS5 Polymerase Domain To Be Published.