Zinc in PDB 7zh4: USP1 Bound to ML323 and Ubiquitin Conjugated to FANCD2 (Focused Refinement)

All present enzymatic activity of USP1 Bound to ML323 and Ubiquitin Conjugated to FANCD2 (Focused Refinement):
3.4.19.12;

The binding sites of Zinc atom in the USP1 Bound to ML323 and Ubiquitin Conjugated to FANCD2 (Focused Refinement) (pdb code 7zh4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the USP1 Bound to ML323 and Ubiquitin Conjugated to FANCD2 (Focused Refinement), PDB code: 7zh4:

Zinc binding site 1 out of 1 in the USP1 Bound to ML323 and Ubiquitin Conjugated to FANCD2 (Focused Refinement)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of USP1 Bound to ML323 and Ubiquitin Conjugated to FANCD2 (Focused Refinement) within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1000 b:28.3 occ:1.00 SG D:CYS443 2.3 9.3 1.0 SG D:CYS509 2.3 8.9 1.0 SG D:CYS506 2.3 7.6 1.0 SG D:CYS440 2.4 8.3 1.0 CB D:CYS440 3.2 8.3 1.0 CB D:CYS506 3.3 7.6 1.0 CB D:CYS443 3.3 9.3 1.0 CB D:CYS509 3.6 8.9 1.0 N D:CYS443 3.7 9.3 1.0 N D:CYS509 3.9 8.9 1.0 CA D:CYS443 4.1 9.3 1.0 O D:HOH1128 4.3 13.0 1.0 CA D:CYS509 4.4 8.9 1.0 CB D:ASN508 4.4 9.9 1.0 CB D:GLU442 4.4 9.6 1.0 CG2 D:THR513 4.5 6.8 1.0 OD1 D:ASN508 4.5 9.9 1.0 CA D:CYS440 4.7 8.3 1.0 CA D:CYS506 4.7 7.6 1.0 C D:ASN508 4.7 9.9 1.0 OG1 D:THR513 4.8 6.8 1.0 C D:GLU442 4.8 9.6 1.0 C D:CYS443 4.8 9.3 1.0 N D:GLU444 4.9 9.7 1.0 CG D:ASN508 4.9 9.9 1.0 CA D:ASN508 5.0 9.9 1.0 CA D:GLU442 5.0 9.6 1.0 N D:GLU442 5.0 9.6 1.0

M.L.Rennie, C.Arkinson, V.K.Chaugule, H.Walden. Cryo-Em Reveals A Mechanism of USP1 Inhibition Through A Cryptic Binding Site. Sci Adv V. 8 Q6353 2022.
ISSN: ESSN 2375-2548
PubMed: 36170365
DOI: 10.1126/SCIADV.ABQ6353