Zinc in PDB 7zf2: Protomeric Substructure From An Octameric Assembly of M. Tuberculosis Rna Polymerase in Complex with Sigma-B Initiation Factor

All present enzymatic activity of Protomeric Substructure From An Octameric Assembly of M. Tuberculosis Rna Polymerase in Complex with Sigma-B Initiation Factor:
2.7.7.6;

The structure of Protomeric Substructure From An Octameric Assembly of M. Tuberculosis Rna Polymerase in Complex with Sigma-B Initiation Factor also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Zinc atom in the Protomeric Substructure From An Octameric Assembly of M. Tuberculosis Rna Polymerase in Complex with Sigma-B Initiation Factor (pdb code 7zf2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Protomeric Substructure From An Octameric Assembly of M. Tuberculosis Rna Polymerase in Complex with Sigma-B Initiation Factor, PDB code: 7zf2:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Protomeric Substructure From An Octameric Assembly of M. Tuberculosis Rna Polymerase in Complex with Sigma-B Initiation Factor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Protomeric Substructure From An Octameric Assembly of M. Tuberculosis Rna Polymerase in Complex with Sigma-B Initiation Factor within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1401 b:111.1 occ:1.00 SG D:CYS891 2.3 77.4 1.0 SG D:CYS978 2.3 63.8 1.0 SG D:CYS968 2.3 71.4 1.0 SG D:CYS975 2.3 61.7 1.0 CB D:CYS975 2.4 61.7 1.0 CB D:CYS978 2.5 63.8 1.0 CB D:CYS891 3.4 77.4 1.0 CA D:CYS975 3.6 61.7 1.0 CB D:CYS968 3.6 71.4 1.0 CA D:CYS978 3.7 63.8 1.0 N D:CYS978 3.7 63.8 1.0 N D:CYS975 3.8 61.7 1.0 CA D:CYS968 4.0 71.4 1.0 N D:CYS891 4.1 77.4 1.0 C D:CYS975 4.2 61.7 1.0 N D:ALA969 4.2 71.3 1.0 O D:CYS975 4.3 61.7 1.0 CA D:CYS891 4.4 77.4 1.0 C D:CYS968 4.6 71.4 1.0 C D:ASP890 4.7 70.8 1.0 C D:CYS978 4.8 63.8 1.0 NH2 D:ARG963 4.8 73.1 1.0 OG1 D:THR970 4.9 67.9 1.0 C D:VAL974 5.0 55.2 1.0

Zinc binding site 2 out of 2 in the Protomeric Substructure From An Octameric Assembly of M. Tuberculosis Rna Polymerase in Complex with Sigma-B Initiation Factor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Protomeric Substructure From An Octameric Assembly of M. Tuberculosis Rna Polymerase in Complex with Sigma-B Initiation Factor within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1402 b:211.8 occ:1.00 SG D:CYS62 2.3 163.4 1.0 SG D:CYS78 2.3 153.9 1.0 SG D:CYS60 2.3 154.4 1.0 SG D:CYS75 2.3 153.9 1.0 CB D:CYS60 2.9 154.4 1.0 CB D:CYS75 3.1 153.9 1.0 CB D:CYS78 3.8 153.9 1.0 CB D:CYS62 3.9 163.4 1.0 N D:CYS62 4.0 163.4 1.0 N D:LYS64 4.1 156.3 1.0 CB D:LYS64 4.1 156.3 1.0 N D:GLY63 4.2 159.0 1.0 N D:CYS78 4.2 153.9 1.0 CA D:CYS60 4.3 154.4 1.0 CA D:CYS62 4.4 163.4 1.0 N D:TYR61 4.5 147.8 1.0 C D:CYS62 4.6 163.4 1.0 C D:CYS60 4.6 154.4 1.0 CA D:CYS75 4.6 153.9 1.0 CA D:CYS78 4.6 153.9 1.0 CA D:LYS64 4.7 156.3 1.0

Z.Morichaud, S.Trapani, R.K.Vishwakarma, L.Chaloin, C.Lionne, J.Lai-Kee-Him, P.Bron, K.Brodolin. Structural Basis of the Mycobacterial Stress-Response Rna Polymerase Auto-Inhibition Via Oligomerization Nat Commun V. 14 484 2023.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-023-36113-Y