Zinc in PDB 7xsq: Structure of the Craspase

The binding sites of Zinc atom in the Structure of the Craspase (pdb code 7xsq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of the Craspase, PDB code: 7xsq:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of the Craspase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Craspase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1801 b:76.9 occ:1.00 SG A:CYS88 2.4 45.8 1.0 SG A:CYS127 2.4 45.9 1.0 SG A:CYS130 2.5 42.7 1.0 SG A:CYS121 2.5 61.3 1.0 CB A:CYS127 3.3 45.9 1.0 CB A:CYS121 3.6 61.3 1.0 CB A:CYS130 3.6 42.7 1.0 CB A:CYS88 3.8 45.8 1.0 N A:CYS127 3.8 45.9 1.0 CA A:CYS127 4.1 45.9 1.0 N A:CYS88 4.2 45.8 1.0 N A:CYS130 4.4 42.7 1.0 CA A:CYS88 4.6 45.8 1.0 CA A:CYS130 4.6 42.7 1.0 C A:CYS127 4.8 45.9 1.0 O A:CYS127 4.9 45.9 1.0 NH1 A:ARG135 5.0 44.5 1.0 C A:ALA126 5.0 49.4 1.0

Zinc binding site 2 out of 4 in the Structure of the Craspase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the Craspase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1802 b:77.0 occ:1.00 SG A:CYS491 2.4 46.5 1.0 SG A:CYS503 2.4 43.5 1.0 SG A:CYS506 2.5 41.8 1.0 SG A:CYS501 2.5 44.1 1.0 CB A:CYS501 3.2 44.1 1.0 CB A:CYS491 3.5 46.5 1.0 CB A:CYS506 3.6 41.8 1.0 CB A:CYS503 3.6 43.5 1.0 N A:CYS503 4.4 43.5 1.0 N A:CYS491 4.5 46.5 1.0 N A:CYS506 4.5 41.8 1.0 CA A:CYS491 4.6 46.5 1.0 CA A:CYS503 4.6 43.5 1.0 CA A:CYS501 4.6 44.1 1.0 CA A:CYS506 4.6 41.8 1.0 C A:CYS501 4.8 44.1 1.0

Zinc binding site 3 out of 4 in the Structure of the Craspase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of the Craspase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1803 b:65.6 occ:1.00 ND1 A:HIS747 2.1 59.9 1.0 CE1 A:HIS747 2.4 59.9 1.0 SG A:CYS752 2.4 51.0 1.0 SG A:CYS750 2.4 58.4 1.0 SG A:CYS755 2.5 44.6 1.0 CB A:CYS750 3.2 58.4 1.0 CG A:HIS747 3.4 59.9 1.0 CB A:CYS752 3.5 51.0 1.0 CB A:CYS755 3.6 44.6 1.0 NE2 A:HIS747 3.7 59.9 1.0 N A:CYS752 4.2 51.0 1.0 CD2 A:HIS747 4.2 59.9 1.0 CB A:HIS747 4.3 59.9 1.0 NZ A:LYS744 4.4 57.7 1.0 CA A:CYS752 4.4 51.0 1.0 CA A:HIS747 4.5 59.9 1.0 N A:CYS755 4.6 44.6 1.0 CA A:CYS750 4.6 58.4 1.0 CA A:CYS755 4.7 44.6 1.0 C A:CYS750 4.8 58.4 1.0 O A:HIS747 4.8 59.9 1.0 CD A:LYS744 4.9 57.7 1.0 CE A:LYS744 4.9 57.7 1.0 N A:THR751 4.9 54.7 1.0 CG A:MET754 4.9 45.3 1.0

Zinc binding site 4 out of 4 in the Structure of the Craspase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of the Craspase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1804 b:60.2 occ:1.00 SG A:CYS1018 2.4 43.5 1.0 SG A:CYS1417 2.4 36.6 1.0 SG A:CYS1406 2.5 47.5 1.0 SG A:CYS1414 2.5 41.0 1.0 CB A:CYS1414 3.2 41.0 1.0 CB A:CYS1417 3.4 36.6 1.0 CB A:CYS1406 3.8 47.5 1.0 CB A:CYS1018 3.8 43.5 1.0 N A:CYS1414 4.2 41.0 1.0 N A:CYS1406 4.2 47.5 1.0 CA A:CYS1414 4.2 41.0 1.0 N A:CYS1417 4.3 36.6 1.0 N A:CYS1018 4.4 43.5 1.0 CA A:CYS1417 4.5 36.6 1.0 CA A:CYS1406 4.6 47.5 1.0 CA A:CYS1018 4.6 43.5 1.0 NH1 A:ARG935 4.9 42.7 1.0 C A:CYS1414 4.9 41.0 1.0

X.Liu, L.Zhang, H.Wang, Y.Xiu, L.Huang, Z.Gao, N.Li, F.Li, W.Xiong, T.Gao, Y.Zhang, M.Yang, Y.Feng. Target Rna Activates the Protease Activity of Craspase to Confer Antiviral Defense. Mol.Cell V. 82 4503 2022.
ISSN: ISSN 1097-2765
PubMed: 36306795
DOI: 10.1016/J.MOLCEL.2022.10.007