Zinc in PDB 7xez: uc(Nmr) Solution Structures of P300 TAZ2 Domain in Complex with BRD4-Nut F1C Domain Binding Motif #2

All present enzymatic activity of uc(Nmr) Solution Structures of P300 TAZ2 Domain in Complex with BRD4-Nut F1C Domain Binding Motif #2:
2.3.1.48;

The binding sites of Zinc atom in the uc(Nmr) Solution Structures of P300 TAZ2 Domain in Complex with BRD4-Nut F1C Domain Binding Motif #2 (pdb code 7xez). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the uc(Nmr) Solution Structures of P300 TAZ2 Domain in Complex with BRD4-Nut F1C Domain Binding Motif #2, PDB code: 7xez:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the uc(Nmr) Solution Structures of P300 TAZ2 Domain in Complex with BRD4-Nut F1C Domain Binding Motif #2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of uc(Nmr) Solution Structures of P300 TAZ2 Domain in Complex with BRD4-Nut F1C Domain Binding Motif #2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:0.0 occ:1.00 NE2 A:HIS49 2.2 0.0 1.0 SG A:CYS53 2.2 0.0 1.0 SG A:CYS61 2.3 0.0 1.0 SG A:CYS64 2.3 0.0 1.0 HA A:LYS56 2.5 0.0 1.0 HB2 A:CYS64 3.0 0.0 1.0 CD2 A:HIS49 3.0 0.0 1.0 HB2 A:CYS53 3.1 0.0 1.0 H A:CYS64 3.1 0.0 1.0 CB A:CYS53 3.2 0.0 1.0 CE1 A:HIS49 3.2 0.0 1.0 HD2 A:HIS49 3.2 0.0 1.0 CB A:CYS61 3.2 0.0 1.0 CB A:CYS64 3.2 0.0 1.0 HB2 A:CYS61 3.3 0.0 1.0 HB3 A:CYS61 3.4 0.0 1.0 HB3 A:CYS53 3.4 0.0 1.0 HE1 A:HIS49 3.5 0.0 1.0 CA A:LYS56 3.5 0.0 1.0 HB A:ILE63 3.9 0.0 1.0 N A:CYS64 3.9 0.0 1.0 HB2 A:LYS56 3.9 0.0 1.0 HA A:THR50 4.0 0.0 1.0 N A:LYS56 4.0 0.0 1.0 HB3 A:CYS64 4.1 0.0 1.0 HG23 A:ILE63 4.1 0.0 1.0 HG3 A:LYS56 4.1 0.0 1.0 CA A:CYS64 4.1 0.0 1.0 CG A:HIS49 4.2 0.0 1.0 CB A:LYS56 4.2 0.0 1.0 ND1 A:HIS49 4.2 0.0 1.0 HG3 A:ARG55 4.2 0.0 1.0 H A:LYS56 4.4 0.0 1.0 HG2 A:ARG55 4.4 0.0 1.0 O A:LYS56 4.4 0.0 1.0 C A:LYS56 4.5 0.0 1.0 HA A:CYS64 4.6 0.0 1.0 CA A:CYS53 4.6 0.0 1.0 C A:ARG55 4.6 0.0 1.0 CA A:CYS61 4.7 0.0 1.0 CG A:LYS56 4.7 0.0 1.0 CB A:ILE63 4.7 0.0 1.0 H A:CYS61 4.8 0.0 1.0 HA A:CYS53 4.8 0.0 1.0 O A:HIS49 4.8 0.0 1.0 CG2 A:ILE63 4.8 0.0 1.0 CG A:ARG55 4.8 0.0 1.0 O A:ARG55 4.8 0.0 1.0 H A:LYS54 4.9 0.0 1.0 C A:ILE63 5.0 0.0 1.0

Zinc binding site 2 out of 3 in the uc(Nmr) Solution Structures of P300 TAZ2 Domain in Complex with BRD4-Nut F1C Domain Binding Motif #2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of uc(Nmr) Solution Structures of P300 TAZ2 Domain in Complex with BRD4-Nut F1C Domain Binding Motif #2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn502 b:0.0 occ:1.00 NE2 A:HIS26 2.2 0.0 1.0 SG A:CYS40 2.4 0.0 1.0 SG A:CYS30 2.4 0.0 1.0 SG A:CYS35 2.6 0.0 1.0 HB2 A:CYS40 3.1 0.0 1.0 CD2 A:HIS26 3.1 0.0 1.0 HB3 A:CYS35 3.1 0.0 1.0 HB2 A:CYS30 3.2 0.0 1.0 CE1 A:HIS26 3.2 0.0 1.0 HD2 A:HIS26 3.3 0.0 1.0 CB A:CYS40 3.3 0.0 1.0 CB A:CYS30 3.3 0.0 1.0 CB A:CYS35 3.5 0.0 1.0 HE1 A:HIS26 3.5 0.0 1.0 HB3 A:CYS30 3.6 0.0 1.0 HB3 A:CYS40 3.7 0.0 1.0 HB2 A:CYS35 4.0 0.0 1.0 HB2 A:LEU37 4.1 0.0 1.0 CG A:HIS26 4.3 0.0 1.0 HE3 A:LYS44 4.3 0.0 1.0 ND1 A:HIS26 4.3 0.0 1.0 H A:LEU37 4.3 0.0 1.0 HD12 A:LEU37 4.6 0.0 1.0 O A:CYS35 4.7 0.0 1.0 HB3 A:ASN32 4.7 0.0 1.0 CA A:CYS40 4.7 0.0 1.0 HA A:ALA27 4.7 0.0 1.0 CA A:CYS35 4.7 0.0 1.0 C A:CYS35 4.7 0.0 1.0 CA A:CYS30 4.7 0.0 1.0 HA A:CYS40 4.8 0.0 1.0 HD3 A:LYS44 4.8 0.0 1.0 HA A:CYS30 4.9 0.0 1.0 O A:ASN32 5.0 0.0 1.0

Zinc binding site 3 out of 3 in the uc(Nmr) Solution Structures of P300 TAZ2 Domain in Complex with BRD4-Nut F1C Domain Binding Motif #2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of uc(Nmr) Solution Structures of P300 TAZ2 Domain in Complex with BRD4-Nut F1C Domain Binding Motif #2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn503 b:0.0 occ:1.00 NE2 A:HIS74 2.1 0.0 1.0 SG A:CYS83 2.3 0.0 1.0 SG A:CYS88 2.4 0.0 1.0 SG A:CYS78 2.4 0.0 1.0 HB A:VAL85 2.9 0.0 1.0 CD2 A:HIS74 3.0 0.0 1.0 HB2 A:CYS83 3.1 0.0 1.0 CE1 A:HIS74 3.1 0.0 1.0 CB A:CYS83 3.2 0.0 1.0 HD2 A:HIS74 3.2 0.0 1.0 HB2 A:CYS78 3.2 0.0 1.0 CB A:CYS88 3.3 0.0 1.0 HB2 A:CYS88 3.3 0.0 1.0 CB A:CYS78 3.3 0.0 1.0 HB3 A:CYS88 3.3 0.0 1.0 HE1 A:HIS74 3.4 0.0 1.0 HB3 A:CYS78 3.4 0.0 1.0 HB3 A:CYS83 3.5 0.0 1.0 HA A:ALA75 3.7 0.0 1.0 CB A:VAL85 3.9 0.0 1.0 CG A:HIS74 4.1 0.0 1.0 HG13 A:VAL85 4.1 0.0 1.0 ND1 A:HIS74 4.1 0.0 1.0 H A:VAL85 4.1 0.0 1.0 HG21 A:VAL85 4.2 0.0 1.0 HB2 A:GLU80 4.2 0.0 1.0 HZ3 A:LYS92 4.2 0.0 1.0 HG23 A:VAL85 4.2 0.0 1.0 HE3 A:LYS92 4.3 0.0 1.0 HD2 A:PRO84 4.3 0.0 1.0 CG2 A:VAL85 4.4 0.0 1.0 H A:GLU80 4.6 0.0 1.0 CG1 A:VAL85 4.6 0.0 1.0 HB1 A:ALA75 4.6 0.0 1.0 O A:GLU80 4.6 0.0 1.0 CA A:CYS83 4.6 0.0 1.0 CA A:ALA75 4.7 0.0 1.0 CA A:CYS88 4.8 0.0 1.0 CA A:CYS78 4.8 0.0 1.0 HZ2 A:LYS92 4.8 0.0 1.0 HA A:CYS83 4.8 0.0 1.0 NZ A:LYS92 4.9 0.0 1.0 N A:VAL85 4.9 0.0 1.0 HG12 A:VAL85 4.9 0.0 1.0 CA A:VAL85 5.0 0.0 1.0 O A:HIS74 5.0 0.0 1.0 N A:ALA75 5.0 0.0 1.0

D.Yu, L.Zeng, M.-M.Zhou. Structural Mechanism of BRD4-Nut Fusion Protein in P300-Activated Hyperacetylation To Be Published.