Zinc in PDB 7xd8: Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form)

Protein crystallography data

The structure of Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form), PDB code: 7xd8 was solved by J.Wu, X.Wang, P.Gong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.92 / 2.85
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 141.728, 156.319, 174.424, 90, 94.22, 90
R / Rfree (%) 19.9 / 24.3

Zinc Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Zinc atom in the Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) (pdb code 7xd8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 12 binding sites of Zinc where determined in the Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form), PDB code: 7xd8:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Zinc binding site 1 out of 12 in 7xd8

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Zinc binding site 1 out of 12 in the Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form)


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Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2001

b:51.7
occ:0.86
 NE2 A:HIS714 1.9 57.2 1.0
NE2 A:HIS712 2.0 51.7 1.0
SG A:CYS728 2.1 47.1 1.0
SG A:CYS847 2.2 58.8 1.0
CE1 A:HIS714 2.7 59.5 1.0
CE1 A:HIS712 2.9 52.0 1.0
CD2 A:HIS714 3.0 56.9 1.0
CD2 A:HIS712 3.1 53.6 1.0
CB A:CYS847 3.2 59.6 1.0
CB A:CYS728 3.2 50.9 1.0
ND1 A:HIS714 3.8 56.1 1.0
CG A:HIS714 4.0 54.7 1.0
ND1 A:HIS712 4.0 47.3 1.0
CG A:HIS712 4.2 53.7 1.0
CD1 A:LEU839 4.5 61.3 1.0
CA A:CYS728 4.5 47.4 1.0
C A:CYS728 4.5 51.5 1.0
NH1 A:ARG769 4.6 50.8 1.0
CA A:CYS847 4.6 60.8 1.0
O A:CYS728 4.7 51.4 1.0
N A:ARG729 5.0 52.9 1.0

Zinc binding site 2 out of 12 in 7xd8

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Zinc binding site 2 out of 12 in the Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form)


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Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2002

b:51.8
occ:0.78
 OE2 A:GLU438 2.1 62.5 1.0
NE2 A:HIS442 2.1 61.0 1.0
SG A:CYS447 2.2 71.5 1.0
SG A:CYS450 2.3 64.6 1.0
CE1 A:HIS442 2.7 60.8 1.0
CD A:GLU438 2.9 64.6 1.0
CG A:GLU438 2.9 60.8 1.0
CD2 A:HIS442 3.3 65.8 1.0
CB A:CYS450 3.4 56.6 1.0
CB A:CYS447 3.6 64.5 1.0
N A:CYS450 3.8 57.5 1.0
ND1 A:HIS442 3.9 65.6 1.0
CA A:CYS447 4.0 58.5 1.0
OE1 A:GLU438 4.1 68.3 1.0
CA A:CYS450 4.2 59.2 1.0
CG2 A:THR572 4.3 58.1 1.0
CG A:HIS442 4.3 66.2 1.0
N A:THR449 4.3 61.3 1.0
OG1 A:THR449 4.3 65.2 1.0
N A:GLU448 4.4 62.8 1.0
CB A:GLU438 4.4 59.2 1.0
C A:CYS447 4.5 61.8 1.0
C A:THR449 4.7 62.7 1.0
CA A:THR449 5.0 60.1 1.0

Zinc binding site 3 out of 12 in 7xd8

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Zinc binding site 3 out of 12 in the Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form)


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Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn2001

b:47.1
occ:0.85
 NE2 D:HIS714 1.9 55.0 1.0
NE2 D:HIS712 2.0 58.2 1.0
SG D:CYS728 2.2 105.2 1.0
SG D:CYS847 2.2 54.8 1.0
CB D:CYS728 2.8 54.7 1.0
CE1 D:HIS714 2.8 51.8 1.0
CD2 D:HIS714 2.8 61.0 1.0
CE1 D:HIS712 2.9 55.3 1.0
CD2 D:HIS712 2.9 47.0 1.0
CB D:CYS847 3.2 63.6 1.0
ND1 D:HIS714 3.9 52.4 1.0
CG D:HIS714 3.9 55.0 1.0
ND1 D:HIS712 4.0 48.0 1.0
CG D:HIS712 4.1 51.4 1.0
CA D:CYS728 4.1 54.6 1.0
C D:CYS728 4.2 55.5 1.0
CD1 D:LEU839 4.4 52.9 1.0
N D:ARG729 4.4 59.0 1.0
CA D:CYS847 4.6 48.4 1.0
O D:ARG729 4.7 56.8 1.0
O D:CYS728 4.7 50.1 1.0

Zinc binding site 4 out of 12 in 7xd8

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Zinc binding site 4 out of 12 in the Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form)


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Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn2002

b:74.7
occ:0.90
 NE2 D:HIS442 2.2 78.2 1.0
OE1 D:GLU438 2.2 86.5 1.0
SG D:CYS447 2.3 77.9 1.0
SG D:CYS450 2.3 82.9 1.0
CD2 D:HIS442 2.9 77.5 1.0
CB D:CYS450 3.0 79.5 1.0
CD D:GLU438 3.2 78.8 1.0
CE1 D:HIS442 3.3 78.3 1.0
CB D:CYS447 3.4 82.2 1.0
CG D:GLU438 3.4 80.3 1.0
CA D:CYS447 3.8 79.0 1.0
N D:CYS450 3.8 79.8 1.0
CA D:CYS450 4.0 79.3 1.0
CG D:HIS442 4.1 79.6 1.0
CG2 D:THR572 4.2 70.8 1.0
N D:GLU448 4.3 77.0 1.0
ND1 D:HIS442 4.3 73.8 1.0
OE2 D:GLU438 4.3 80.8 1.0
C D:CYS447 4.4 78.1 1.0
N D:THR449 4.6 76.7 1.0
NH1 D:ARG280 4.7 74.7 1.0
C D:THR449 4.8 83.2 1.0
O D:LYS446 4.9 85.0 1.0
CB D:GLU438 4.9 81.1 1.0
CD1 D:LEU484 5.0 71.0 1.0

Zinc binding site 5 out of 12 in 7xd8

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Zinc binding site 5 out of 12 in the Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form)


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Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Zn2001

b:51.3
occ:0.85
 NE2 G:HIS712 1.9 53.8 1.0
NE2 G:HIS714 2.0 62.8 1.0
SG G:CYS847 2.2 57.8 1.0
SG G:CYS728 2.2 63.1 1.0
CD2 G:HIS714 2.6 52.8 1.0
CD2 G:HIS712 2.9 62.3 1.0
CE1 G:HIS712 3.0 56.2 1.0
CB G:CYS728 3.1 55.0 1.0
CB G:CYS847 3.1 52.9 1.0
CE1 G:HIS714 3.3 60.0 1.0
CG G:HIS714 3.9 55.7 1.0
CG G:HIS712 4.0 63.5 1.0
ND1 G:HIS712 4.0 63.0 1.0
ND1 G:HIS714 4.2 57.5 1.0
CA G:CYS728 4.3 56.8 1.0
CD1 G:LEU839 4.5 69.5 1.0
C G:CYS728 4.5 60.2 1.0
CA G:CYS847 4.5 57.9 1.0
NH1 G:ARG769 4.6 53.5 1.0
N G:ARG729 4.7 60.1 1.0
O G:ARG729 4.9 55.9 1.0
O G:CYS728 4.9 61.4 1.0

Zinc binding site 6 out of 12 in 7xd8

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Zinc binding site 6 out of 12 in the Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Zn2002

b:68.7
occ:0.80
 OE2 G:GLU438 2.2 81.0 1.0
NE2 G:HIS442 2.2 72.0 1.0
SG G:CYS447 2.3 67.5 1.0
SG G:CYS450 2.3 66.2 1.0
CD G:GLU438 2.8 78.1 1.0
CE1 G:HIS442 2.8 74.7 1.0
CG G:GLU438 3.0 69.2 1.0
CB G:CYS450 3.1 67.0 1.0
CD2 G:HIS442 3.2 78.8 1.0
CB G:CYS447 3.5 81.4 1.0
N G:CYS450 3.8 70.9 1.0
OE1 G:GLU438 3.8 82.2 1.0
CA G:CYS447 3.9 82.3 1.0
ND1 G:HIS442 4.0 73.2 1.0
CA G:CYS450 4.0 71.1 1.0
CG G:HIS442 4.2 80.0 1.0
N G:GLU448 4.2 84.0 1.0
C G:CYS447 4.5 78.6 1.0
CG2 G:THR572 4.5 65.3 1.0
CB G:GLU438 4.5 74.7 1.0
N G:THR449 4.5 77.3 1.0
C G:THR449 4.8 76.7 1.0
CD1 G:LEU484 4.9 64.8 1.0

Zinc binding site 7 out of 12 in 7xd8

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Zinc binding site 7 out of 12 in the Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Zn2001

b:55.5
occ:0.80
 NE2 J:HIS712 1.9 65.5 1.0
NE2 J:HIS714 2.0 71.5 1.0
SG J:CYS847 2.1 64.6 1.0
SG J:CYS728 2.2 56.6 1.0
CE1 J:HIS712 2.8 64.0 1.0
CD2 J:HIS714 2.9 62.7 1.0
CD2 J:HIS712 2.9 62.0 1.0
CE1 J:HIS714 3.0 65.1 1.0
CB J:CYS847 3.2 57.7 1.0
CB J:CYS728 3.3 58.0 1.0
ND1 J:HIS712 3.9 62.8 1.0
CG J:HIS712 4.0 60.4 1.0
CG J:HIS714 4.0 66.7 1.0
ND1 J:HIS714 4.0 64.2 1.0
CA J:CYS728 4.5 56.7 1.0
CD1 J:LEU839 4.5 64.7 1.0
C J:CYS728 4.5 61.0 1.0
CA J:CYS847 4.6 57.7 1.0
N J:ARG729 4.7 63.2 1.0
NH1 J:ARG769 5.0 58.9 1.0

Zinc binding site 8 out of 12 in 7xd8

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Zinc binding site 8 out of 12 in the Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Zn2002

b:65.3
occ:0.97
 SG J:CYS450 2.2 67.8 1.0
NE2 J:HIS442 2.2 59.0 1.0
SG J:CYS447 2.3 65.3 1.0
OE2 J:GLU438 2.3 62.7 1.0
CD2 J:HIS442 2.8 62.7 1.0
CG J:GLU438 3.0 62.2 1.0
CD J:GLU438 3.1 65.2 1.0
CE1 J:HIS442 3.2 65.3 1.0
CB J:CYS447 3.5 62.6 1.0
CB J:CYS450 3.6 72.2 1.0
CA J:CYS447 3.7 64.3 1.0
N J:CYS450 3.8 60.7 1.0
CG J:HIS442 4.0 65.2 1.0
N J:GLU448 4.1 66.5 1.0
ND1 J:HIS442 4.1 68.2 1.0
CA J:CYS450 4.3 64.5 1.0
C J:CYS447 4.3 63.5 1.0
OE1 J:GLU438 4.3 68.9 1.0
N J:THR449 4.4 68.1 1.0
CB J:GLU438 4.5 62.5 1.0
CG2 J:THR572 4.6 53.2 1.0
O J:LYS446 4.8 69.0 1.0
C J:THR449 4.8 59.1 1.0
OG1 J:THR449 4.8 70.6 1.0
O J:GLU438 4.9 67.7 1.0
N J:CYS447 5.0 68.1 1.0

Zinc binding site 9 out of 12 in 7xd8

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Zinc binding site 9 out of 12 in the Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
M:Zn2001

b:69.0
occ:0.99
 NE2 M:HIS712 1.9 60.9 1.0
NE2 M:HIS714 2.0 65.5 1.0
SG M:CYS728 2.2 74.0 1.0
SG M:CYS847 2.3 75.6 1.0
CE1 M:HIS714 2.6 60.1 1.0
CE1 M:HIS712 2.6 60.0 1.0
CD2 M:HIS712 3.2 60.0 1.0
CB M:CYS728 3.2 54.8 1.0
CD2 M:HIS714 3.2 64.4 1.0
CB M:CYS847 3.4 57.0 1.0
ND1 M:HIS714 3.8 66.5 1.0
ND1 M:HIS712 3.9 57.3 1.0
CG M:HIS714 4.1 63.7 1.0
CG M:HIS712 4.1 52.1 1.0
CA M:CYS728 4.4 52.4 1.0
N M:ARG729 4.5 58.9 1.0
C M:CYS728 4.5 55.6 1.0
CD1 M:LEU839 4.6 59.1 1.0
CA M:CYS847 4.7 62.3 1.0
O M:GLU843 4.9 67.5 1.0
NH1 M:ARG769 5.0 55.6 1.0

Zinc binding site 10 out of 12 in 7xd8

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Zinc binding site 10 out of 12 in the Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 10 of Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
M:Zn2002

b:52.8
occ:0.80
 OE1 M:GLU438 1.9 56.7 1.0
SG M:CYS450 2.2 71.9 1.0
SG M:CYS447 2.2 59.8 1.0
NE2 M:HIS442 2.3 59.5 1.0
CD M:GLU438 2.9 62.1 1.0
CD2 M:HIS442 3.0 51.5 1.0
CB M:CYS450 3.2 62.2 1.0
CE1 M:HIS442 3.3 55.9 1.0
CG M:GLU438 3.3 57.3 1.0
CB M:CYS447 3.6 57.8 1.0
CA M:CYS447 3.9 62.3 1.0
N M:CYS450 4.0 58.4 1.0
OE2 M:GLU438 4.0 64.2 1.0
CG2 M:THR572 4.1 53.8 1.0
N M:GLU448 4.1 64.4 1.0
CG M:HIS442 4.2 59.7 1.0
CA M:CYS450 4.2 62.5 1.0
ND1 M:HIS442 4.3 57.8 1.0
N M:THR449 4.5 62.1 1.0
C M:CYS447 4.5 63.7 1.0
CB M:GLU438 4.9 59.4 1.0
OG1 M:THR449 4.9 54.5 1.0
C M:THR449 4.9 58.4 1.0
O M:LYS446 4.9 66.5 1.0

Reference:

J.Wu, X.Wang, Q.Liu, G.Lu, P.Gong. Structural Basis of Transition From Initiation to Elongation in De Novo Viral Rna-Dependent Rna Polymerases Proc.Natl.Acad.Sci.Usa 2022.
ISSN: ESSN 1091-6490
Page generated: Wed Oct 30 14:57:48 2024

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