Zinc in PDB 7wnm: Structure of Sars-Cov-2 Gamma Variant Receptor-Binding Domain Complexed with High Affinity Human ACE2 Mutant (T27F,R273Q)

Enzymatic activity of Structure of Sars-Cov-2 Gamma Variant Receptor-Binding Domain Complexed with High Affinity Human ACE2 Mutant (T27F,R273Q)

All present enzymatic activity of Structure of Sars-Cov-2 Gamma Variant Receptor-Binding Domain Complexed with High Affinity Human ACE2 Mutant (T27F,R273Q):
3.4.17.23;

Protein crystallography data

The structure of Structure of Sars-Cov-2 Gamma Variant Receptor-Binding Domain Complexed with High Affinity Human ACE2 Mutant (T27F,R273Q), PDB code: 7wnm was solved by R.Y.Ma, P.C.Han, Q.H.Wang, P.Han, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 17.57 / 2.70
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 103.346, 103.346, 233.324, 90, 90, 90
R / Rfree (%) 19.4 / 22.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Sars-Cov-2 Gamma Variant Receptor-Binding Domain Complexed with High Affinity Human ACE2 Mutant (T27F,R273Q) (pdb code 7wnm). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Sars-Cov-2 Gamma Variant Receptor-Binding Domain Complexed with High Affinity Human ACE2 Mutant (T27F,R273Q), PDB code: 7wnm:

Zinc binding site 1 out of 1 in 7wnm

Go back to Zinc Binding Sites List in 7wnm
Zinc binding site 1 out of 1 in the Structure of Sars-Cov-2 Gamma Variant Receptor-Binding Domain Complexed with High Affinity Human ACE2 Mutant (T27F,R273Q)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Sars-Cov-2 Gamma Variant Receptor-Binding Domain Complexed with High Affinity Human ACE2 Mutant (T27F,R273Q) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn801

b:42.2
occ:1.00
 NE2 B:HIS378 2.1 49.3 1.0
OE2 B:GLU402 2.1 56.4 1.0
OE1 B:GLU402 2.1 44.3 1.0
NE2 B:HIS374 2.1 38.3 1.0
CD B:GLU402 2.3 43.9 1.0
O B:HOH944 2.5 34.3 1.0
CD2 B:HIS374 2.9 28.7 1.0
CD2 B:HIS378 3.0 25.7 1.0
CE1 B:HIS378 3.1 25.1 1.0
CE1 B:HIS374 3.2 31.5 1.0
OE2 B:GLU375 3.7 34.8 1.0
CG B:GLU402 3.8 28.5 1.0
CG B:HIS374 4.1 27.0 1.0
OE1 B:GLU375 4.1 49.1 1.0
ND1 B:HIS378 4.2 29.6 1.0
CG B:HIS378 4.2 27.6 1.0
ND1 B:HIS374 4.2 37.9 1.0
CD B:GLU375 4.3 42.9 1.0
CB B:GLU402 4.6 25.8 1.0
CA B:GLU402 4.6 36.5 1.0

Reference:

A.Zheng, L.Wu, R.Ma, P.Han, B.Huang, C.Qiao, Q.Wang, W.Tan, G.F.Gao, P.Han. A Binding-Enhanced But Enzymatic Activity-Eliminated Human ACE2 Efficiently Neutralizes Sars-Cov-2 Variants. Signal Transduct Target Ther V. 7 10 2022.
ISSN: ESSN 2059-3635
PubMed: 35013100
DOI: 10.1038/S41392-021-00821-Y
Page generated: Sat Apr 8 05:18:44 2023

Last articles

Zn in 3HKQ
Zn in 3HKA
Zn in 3HKO
Zn in 3HKN
Zn in 3HK8
Zn in 3HK5
Zn in 3HJT
Zn in 3HJW
Zn in 3HGZ
Zn in 3HI2
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy