Zinc in PDB 7w9s: Crystal Structure of the Enterovirus 71 Polymerase Elongation Complex (C1S3 Form)

Enzymatic activity of Crystal Structure of the Enterovirus 71 Polymerase Elongation Complex (C1S3 Form)

All present enzymatic activity of Crystal Structure of the Enterovirus 71 Polymerase Elongation Complex (C1S3 Form):
2.7.7.48; 3.4.22.28; 3.4.22.29; 3.6.1.15;

Protein crystallography data

The structure of Crystal Structure of the Enterovirus 71 Polymerase Elongation Complex (C1S3 Form), PDB code: 7w9s was solved by M.Wang, P.Gong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.94 / 2.53
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 63.992, 77.663, 150.831, 90, 90, 90
R / Rfree (%) 20 / 24.1

Other elements in 7w9s:

The structure of Crystal Structure of the Enterovirus 71 Polymerase Elongation Complex (C1S3 Form) also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Enterovirus 71 Polymerase Elongation Complex (C1S3 Form) (pdb code 7w9s). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Enterovirus 71 Polymerase Elongation Complex (C1S3 Form), PDB code: 7w9s:

Zinc binding site 1 out of 1 in 7w9s

Go back to Zinc Binding Sites List in 7w9s
Zinc binding site 1 out of 1 in the Crystal Structure of the Enterovirus 71 Polymerase Elongation Complex (C1S3 Form)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Enterovirus 71 Polymerase Elongation Complex (C1S3 Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn505

b:61.5
occ:1.00
 NE2 A:HIS273 2.1 71.8 1.0
NE2 A:HIS271 2.2 62.0 1.0
SG A:CYS282 2.2 62.7 1.0
CD2 A:HIS273 3.0 65.0 1.0
CD2 A:HIS271 3.0 55.5 1.0
CB A:CYS282 3.2 63.8 1.0
CE1 A:HIS273 3.2 71.5 1.0
CE1 A:HIS271 3.3 58.3 1.0
NE1 A:TRP5 3.9 64.9 1.0
CZ2 A:TRP5 4.1 68.2 1.0
CG A:HIS273 4.2 70.4 1.0
CG A:HIS271 4.2 60.3 1.0
ND1 A:HIS273 4.3 75.8 1.0
CE2 A:TRP5 4.3 67.1 1.0
ND1 A:HIS271 4.3 64.0 1.0
CA A:CYS282 4.4 61.7 1.0
O A:THR272 4.8 60.3 1.0

Reference:

R.Li, M.Wang, P.Gong. Crystal Structure of A Pre-Chemistry Viral Rna-Dependent Rna Polymerase Suggests Participation of Two Basic Residues in Catalysis. Nucleic Acids Res. V. 50 12389 2022.
ISSN: ESSN 1362-4962
PubMed: 36477355
DOI: 10.1093/NAR/GKAC1133
Page generated: Sat Apr 8 05:11:49 2023

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