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Zinc in PDB 7w4x: Crystal Structure of PDE4D Catalytic Domain Complexed with 17Enzymatic activity of Crystal Structure of PDE4D Catalytic Domain Complexed with 17
All present enzymatic activity of Crystal Structure of PDE4D Catalytic Domain Complexed with 17:
3.1.4.53; Protein crystallography data
The structure of Crystal Structure of PDE4D Catalytic Domain Complexed with 17, PDB code: 7w4x
was solved by
Y.-Y.Huang,
H.-B.Luo,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7w4x:
The structure of Crystal Structure of PDE4D Catalytic Domain Complexed with 17 also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of PDE4D Catalytic Domain Complexed with 17
(pdb code 7w4x). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of PDE4D Catalytic Domain Complexed with 17, PDB code: 7w4x: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 7w4xGo back to Zinc Binding Sites List in 7w4x
Zinc binding site 1 out
of 2 in the Crystal Structure of PDE4D Catalytic Domain Complexed with 17
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 7w4xGo back to Zinc Binding Sites List in 7w4x
Zinc binding site 2 out
of 2 in the Crystal Structure of PDE4D Catalytic Domain Complexed with 17
Mono view Stereo pair view
Reference:
Z.Song,
Y.Y.Huang,
K.Q.Hou,
L.Liu,
F.Zhou,
Y.Huang,
G.Wan,
H.B.Luo,
X.F.Xiong.
Discovery and Structural Optimization of Toddacoumalone Derivatives As Novel PDE4 Inhibitors For the Topical Treatment of Psoriasis. J.Med.Chem. V. 65 4238 2022.
Page generated: Sat Apr 8 05:08:45 2023
ISSN: ISSN 0022-2623 PubMed: 35188767 DOI: 10.1021/ACS.JMEDCHEM.1C02058 |
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