Zinc in PDB 7uy5: Tetrahymena Telomerase with Cst

All present enzymatic activity of Tetrahymena Telomerase with Cst:
2.7.7.49;

The binding sites of Zinc atom in the Tetrahymena Telomerase with Cst (pdb code 7uy5). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Tetrahymena Telomerase with Cst, PDB code: 7uy5:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Tetrahymena Telomerase with Cst


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Tetrahymena Telomerase with Cst within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn900 b:84.6 occ:1.00 SG D:CYS555 2.3 39.0 1.0 SG D:CYS572 2.3 54.6 1.0 SG D:CYS557 2.3 45.0 1.0 SG D:CYS575 2.3 47.2 1.0 CB D:CYS575 2.9 47.2 1.0 CB D:CYS572 2.9 54.6 1.0 CB D:CYS555 3.3 39.0 1.0 N D:CYS575 3.5 47.2 1.0 CB D:CYS557 3.7 45.0 1.0 CA D:CYS575 3.8 47.2 1.0 N D:CYS557 4.3 45.0 1.0 C D:SER574 4.3 49.0 1.0 CA D:CYS572 4.3 54.6 1.0 CA D:CYS557 4.5 45.0 1.0 N D:SER574 4.6 49.0 1.0 CB D:SER574 4.7 49.0 1.0 CA D:CYS555 4.7 39.0 1.0 C D:CYS575 4.7 47.2 1.0 CG2 D:ILE579 4.7 40.5 1.0 C D:CYS572 4.7 54.6 1.0 CA D:GLY559 4.7 43.7 1.0 CA D:SER574 4.8 49.0 1.0 N D:GLN576 4.8 43.9 1.0 N D:GLY559 4.8 43.7 1.0 N D:GLU573 4.9 47.2 1.0 N D:THR556 4.9 41.0 1.0 C D:CYS557 4.9 45.0 1.0

Zinc binding site 2 out of 2 in the Tetrahymena Telomerase with Cst


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Tetrahymena Telomerase with Cst within 5.0Å range: probe atom residue distance (Å) B Occ I:Zn900 b:9.5 occ:1.00 SG I:CYS401 2.3 6.4 1.0 SG I:CYS415 2.3 6.5 1.0 SG I:CYS398 2.3 8.1 1.0 SG I:CYS412 2.3 6.7 1.0 CB I:CYS412 3.1 6.7 1.0 CB I:CYS398 3.2 8.1 1.0 O I:CYS415 3.7 6.5 1.0 CB I:CYS401 3.7 6.4 1.0 N I:CYS415 3.8 6.5 1.0 CB I:CYS415 3.9 6.5 1.0 N I:CYS401 4.0 6.4 1.0 CA I:CYS415 4.3 6.5 1.0 CB I:ASN414 4.3 7.8 1.0 CA I:CYS401 4.4 6.4 1.0 C I:CYS415 4.4 6.5 1.0 CB I:ASN400 4.5 6.4 1.0 CA I:CYS412 4.6 6.7 1.0 O I:CYS401 4.7 6.4 1.0 CA I:CYS398 4.7 8.1 1.0 C I:ASN414 4.7 7.8 1.0 C I:ASN400 4.8 6.4 1.0 C I:CYS401 4.9 6.4 1.0 N I:ASN414 4.9 7.8 1.0 CA I:ASN414 4.9 7.8 1.0 CB I:GLN403 4.9 7.5 1.0 ND2 I:ASN414 5.0 7.8 1.0

Y.He, H.Song, H.Chan, B.Liu, Y.Wang, L.Susac, Z.H.Zhou, J.Feigon. Structure of Tetrahymena Telomerase-Bound Cst with Polymerase Alpha-Primase. Nature V. 608 813 2022.
ISSN: ESSN 1476-4687
PubMed: 35831498
DOI: 10.1038/S41586-022-04931-7