Zinc in PDB 7usz: Human Ddah-1, Holo (Zn-Bound) Form

Enzymatic activity of Human Ddah-1, Holo (Zn-Bound) Form

All present enzymatic activity of Human Ddah-1, Holo (Zn-Bound) Form:
3.5.3.18;

Protein crystallography data

The structure of Human Ddah-1, Holo (Zn-Bound) Form, PDB code: 7usz was solved by C.A.Smith, Y.T.Ghebre, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.55 / 1.65
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 44.968, 47.634, 146.965, 90, 94.61, 90
R / Rfree (%) 15.1 / 19.9

Other elements in 7usz:

The structure of Human Ddah-1, Holo (Zn-Bound) Form also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Ddah-1, Holo (Zn-Bound) Form (pdb code 7usz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human Ddah-1, Holo (Zn-Bound) Form, PDB code: 7usz:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 7usz

Go back to Zinc Binding Sites List in 7usz
Zinc binding site 1 out of 2 in the Human Ddah-1, Holo (Zn-Bound) Form


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Ddah-1, Holo (Zn-Bound) Form within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:37.3
occ:1.00
O A:HOH469 1.9 23.4 1.0
O A:HOH404 2.1 27.5 1.0
O A:HOH418 2.1 26.5 1.0
SG A:CYS274 2.3 18.6 1.0
CB A:CYS274 3.1 17.1 1.0
ND1 A:HIS173 3.8 32.3 1.0
CA A:CYS274 3.9 13.9 1.0
OD1 A:ASP79 4.0 17.0 1.0
OE2 A:GLU78 4.0 19.7 1.0
OD2 A:ASP79 4.1 18.3 1.0
CE1 A:HIS173 4.3 31.1 1.0
CG A:ASP79 4.5 16.1 1.0
O A:ASP269 4.5 22.8 1.0
N A:CYS274 4.5 13.4 1.0
CA A:GLY129 4.6 13.1 1.0

Zinc binding site 2 out of 2 in 7usz

Go back to Zinc Binding Sites List in 7usz
Zinc binding site 2 out of 2 in the Human Ddah-1, Holo (Zn-Bound) Form


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human Ddah-1, Holo (Zn-Bound) Form within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn301

b:34.6
occ:1.00
O B:HOH427 2.0 24.4 1.0
O B:HOH424 2.1 23.8 1.0
O B:HOH414 2.2 32.3 1.0
SG B:CYS274 2.3 24.2 1.0
CB B:CYS274 3.2 20.8 1.0
ND1 B:HIS173 3.8 34.6 1.0
OE1 B:GLU78 3.9 24.4 1.0
CA B:CYS274 4.0 17.1 1.0
OD1 B:ASP79 4.0 19.7 1.0
OD2 B:ASP79 4.1 23.7 1.0
CE1 B:HIS173 4.3 35.7 1.0
O B:ASP269 4.4 28.4 1.0
CG B:ASP79 4.5 22.3 1.0
N B:CYS274 4.6 17.1 1.0
CA B:GLY129 4.6 16.3 1.0
CG B:HIS173 5.0 31.4 1.0

Reference:

C.A.Smith, A.Ebrahimpour, L.Novikova, D.Farina, A.O.Bailey, W.K.Russell, A.Jain, A.B.Saltzman, A.Malovannaya, B.V.V.Prasad, L.Hu, Y.T.Ghebre. Esomeprazole Covalently Interacts with the Cardiovascular Enzyme Dimethylarginine Dimethylaminohydrolase: Insights Into the Cardiovascular Risk of Proton Pump Inhibitors. Biochim Biophys Acta Gen V.1866 30149 2022SUBJ.
ISSN: ISSN 1872-8006
PubMed: 35472493
DOI: 10.1016/J.BBAGEN.2022.130149
Page generated: Sat Apr 8 04:28:58 2023

Last articles

Ca in 5YQ0
Ca in 5YQS
Ca in 5YNH
Ca in 5YNE
Ca in 5YND
Ca in 5YOT
Ca in 5YN7
Ca in 5YN2
Ca in 5YL7
Ca in 5YKB
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy