Zinc in PDB 7ure: Human Porcn in Complex with Palmitoleoylated WNT3A Peptide

All present enzymatic activity of Human Porcn in Complex with Palmitoleoylated WNT3A Peptide:
2.3.1.250;

The binding sites of Zinc atom in the Human Porcn in Complex with Palmitoleoylated WNT3A Peptide (pdb code 7ure). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Porcn in Complex with Palmitoleoylated WNT3A Peptide, PDB code: 7ure:

Zinc binding site 1 out of 1 in the Human Porcn in Complex with Palmitoleoylated WNT3A Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Porcn in Complex with Palmitoleoylated WNT3A Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn502 b:133.6 occ:1.00 ND1 A:HIS382 2.1 114.3 1.0 SG A:CYS370 2.4 101.6 1.0 SG A:CYS376 2.5 110.7 1.0 CB A:CYS376 2.5 110.7 1.0 CE1 A:HIS382 3.0 114.3 1.0 CG A:HIS382 3.1 114.3 1.0 CB A:CYS380 3.4 121.4 1.0 CB A:HIS382 3.5 114.3 1.0 CB A:CYS370 3.6 101.6 1.0 CA A:CYS376 4.0 110.7 1.0 CA A:CYS370 4.1 101.6 1.0 SG A:CYS380 4.1 121.4 1.0 NE2 A:HIS382 4.2 114.3 1.0 CD2 A:HIS382 4.2 114.3 1.0 N A:CYS376 4.7 110.7 1.0 CA A:HIS382 4.8 114.3 1.0 N A:HIS382 4.8 114.3 1.0 C A:CYS376 4.8 110.7 1.0 CA A:CYS380 4.8 121.4 1.0 N A:CYS370 4.8 101.6 1.0 O A:PRO377 4.8 118.4 1.0 O A:ALA369 5.0 105.3 1.0

Y.Liu, X.Qi, L.Donnelly, N.Elghobashi-Meinhardt, T.Long, R.W.Zhou, Y.Sun, B.Wang, X.Li. Mechanisms and Inhibition of Porcupine-Mediated Wnt Acylation. Nature V. 607 816 2022.
ISSN: ESSN 1476-4687
PubMed: 35831507
DOI: 10.1038/S41586-022-04952-2