Zinc in PDB 7ura: Human Porcn in Complex with Palmitoleoyl-Coa

All present enzymatic activity of Human Porcn in Complex with Palmitoleoyl-Coa:
2.3.1.250;

The binding sites of Zinc atom in the Human Porcn in Complex with Palmitoleoyl-Coa (pdb code 7ura). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Porcn in Complex with Palmitoleoyl-Coa, PDB code: 7ura:

Zinc binding site 1 out of 1 in the Human Porcn in Complex with Palmitoleoyl-Coa


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Porcn in Complex with Palmitoleoyl-Coa within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn502 b:123.2 occ:1.00 ND1 A:HIS382 2.0 109.8 1.0 SG A:CYS380 2.2 114.7 1.0 SG A:CYS376 2.2 107.6 1.0 SG A:CYS370 2.3 100.1 1.0 CE1 A:HIS382 2.7 109.8 1.0 CG A:HIS382 2.9 109.8 1.0 CB A:CYS370 3.2 100.1 1.0 CB A:CYS376 3.3 107.6 1.0 CB A:HIS382 3.5 109.8 1.0 CA A:CYS370 3.5 100.1 1.0 CB A:CYS380 3.5 114.7 1.0 NE2 A:HIS382 3.8 109.8 1.0 CD2 A:HIS382 3.9 109.8 1.0 N A:CYS370 4.2 100.1 1.0 O A:ALA369 4.4 102.7 1.0 CA A:CYS376 4.6 107.6 1.0 C A:ALA369 4.6 102.7 1.0 C A:CYS370 4.7 100.1 1.0 CA A:CYS380 4.8 114.7 1.0 CA A:HIS382 4.8 109.8 1.0 C A:CYS376 4.9 107.6 1.0 O A:PRO377 4.9 115.2 1.0 N A:HIS382 5.0 109.8 1.0

Y.Liu, X.Qi, L.Donnelly, N.Elghobashi-Meinhardt, T.Long, R.W.Zhou, Y.Sun, B.Wang, X.Li. Mechanisms and Inhibition of Porcupine-Mediated Wnt Acylation. Nature V. 607 816 2022.
ISSN: ESSN 1476-4687
PubMed: 35831507
DOI: 10.1038/S41586-022-04952-2