Zinc in PDB 7uhy: Human GATOR2 Complex

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>>> Page 1 <<< Page 2, Binding sites: 11 - 16;

Binding sites:

The binding sites of Zinc atom in the Human GATOR2 Complex (pdb code 7uhy). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 16 binding sites of Zinc where determined in the Human GATOR2 Complex, PDB code: 7uhy:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Zinc binding site 1 out of 16 in the Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:232.7 occ:1.00 SG A:CYS740 2.2 171.3 1.0 SG A:CYS778 2.3 180.4 1.0 SG A:CYS775 2.3 173.7 1.0 SG A:CYS737 2.3 166.2 1.0 CB A:CYS737 2.8 166.2 1.0 CB A:CYS775 3.0 173.7 1.0 CB A:CYS740 3.2 171.3 1.0 CB A:CYS778 3.6 180.4 1.0 N A:CYS740 3.8 171.3 1.0 N A:CYS778 3.9 180.4 1.0 CA A:CYS740 4.1 171.3 1.0 CA A:CYS737 4.3 166.2 1.0 CA A:CYS778 4.4 180.4 1.0 CA A:CYS775 4.5 173.7 1.0 N A:GLY741 4.9 162.5 1.0 C A:CYS737 4.9 166.2 1.0 C A:PHE739 4.9 165.0 1.0 CB A:PHE739 5.0 165.0 1.0 C A:CYS740 5.0 171.3 1.0 N A:PHE739 5.0 165.0 1.0

Zinc binding site 2 out of 16 in the Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1002 b:154.9 occ:1.00 ND1 A:HIS838 2.0 120.3 1.0 ND1 A:HIS835 2.0 120.3 1.0 SG A:CYS788 2.2 122.3 1.0 SG A:CYS785 2.3 125.8 1.0 CG A:HIS835 2.6 120.3 1.0 CE1 A:HIS838 2.6 120.3 1.0 CB A:CYS785 2.8 125.8 1.0 CB A:HIS835 2.9 120.3 1.0 CE1 A:HIS835 3.0 120.3 1.0 CG A:HIS838 3.2 120.3 1.0 N A:HIS835 3.6 120.3 1.0 CD2 A:HIS835 3.7 120.3 1.0 NE2 A:HIS838 3.8 120.3 1.0 CB A:CYS788 3.8 122.3 1.0 CB A:HIS838 3.8 120.3 1.0 CA A:HIS835 3.8 120.3 1.0 NE2 A:HIS835 3.9 120.3 1.0 CD2 A:HIS838 4.0 120.3 1.0 N A:CYS788 4.2 122.3 1.0 CA A:CYS785 4.3 125.8 1.0 CA A:CYS788 4.7 122.3 1.0 C A:GLY834 4.7 117.0 1.0 C A:HIS835 4.8 120.3 1.0 C A:CYS785 5.0 125.8 1.0

Zinc binding site 3 out of 16 in the Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1003 b:184.8 occ:1.00 SG A:CYS830 2.2 145.4 1.0 SG A:CYS856 2.3 153.2 1.0 SG A:CYS827 2.3 137.4 1.0 CB A:CYS830 2.3 145.4 1.0 SG A:CYS858 2.3 154.7 1.0 CB A:CYS856 2.8 153.2 1.0 N A:CYS830 2.8 145.4 1.0 CA A:CYS830 3.1 145.4 1.0 CB A:CYS827 3.4 137.4 1.0 ZN A:ZN1004 3.6 179.8 1.0 C A:ASN829 3.9 135.1 1.0 CB A:CYS858 4.0 154.7 1.0 CB A:ASN829 4.2 135.1 1.0 CA A:CYS856 4.2 153.2 1.0 C A:CYS830 4.2 145.4 1.0 CA A:ASN829 4.4 135.1 1.0 CA A:CYS858 4.5 154.7 1.0 N A:ASN829 4.6 135.1 1.0 N A:ARG831 4.7 132.0 1.0 C A:CYS856 4.7 153.2 1.0 CA A:CYS827 4.7 137.4 1.0 SG A:CYS854 4.8 145.3 1.0 N A:CYS858 4.9 154.7 1.0 O A:ASN829 4.9 135.1 1.0 CG A:ASN829 4.9 135.1 1.0 SG A:CYS849 4.9 136.3 1.0 C A:CYS827 4.9 137.4 1.0 O A:CYS856 4.9 153.2 1.0 O A:CYS827 4.9 137.4 1.0 CB A:CYS849 4.9 136.3 1.0

Zinc binding site 4 out of 16 in the Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1004 b:179.8 occ:1.00 ND1 A:HIS832 2.0 130.6 1.0 CB A:CYS830 2.2 145.4 1.0 SG A:CYS854 2.3 145.3 1.0 SG A:CYS830 2.3 145.4 1.0 SG A:CYS849 2.3 136.3 1.0 CE1 A:HIS832 2.7 130.6 1.0 CG A:HIS832 3.1 130.6 1.0 CB A:CYS849 3.2 136.3 1.0 ZN A:ZN1003 3.6 184.8 1.0 CA A:CYS830 3.6 145.4 1.0 CB A:CYS854 3.7 145.3 1.0 CB A:HIS832 3.7 130.6 1.0 O A:CYS830 3.9 145.4 1.0 NE2 A:HIS832 3.9 130.6 1.0 C A:CYS830 4.0 145.4 1.0 CD2 A:HIS832 4.1 130.6 1.0 CB A:CYS856 4.3 153.2 1.0 N A:HIS832 4.5 130.6 1.0 SG A:CYS858 4.5 154.7 1.0 N A:CYS830 4.7 145.4 1.0 CA A:CYS849 4.7 136.3 1.0 CA A:HIS832 4.7 130.6 1.0 N A:ARG831 4.9 132.0 1.0 CA A:CYS854 5.0 145.3 1.0

Zinc binding site 5 out of 16 in the Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1001 b:339.9 occ:1.00 SG B:CYS778 2.3 265.9 1.0 SG B:CYS740 2.3 262.2 1.0 SG B:CYS737 2.3 252.6 1.0 SG B:CYS775 2.3 267.4 1.0 CB B:CYS740 2.6 262.2 1.0 CB B:CYS737 2.8 252.6 1.0 N B:CYS740 3.3 262.2 1.0 CB B:CYS778 3.4 265.9 1.0 CA B:CYS740 3.5 262.2 1.0 CB B:CYS775 3.7 267.4 1.0 N B:CYS778 3.9 265.9 1.0 CA B:CYS778 4.3 265.9 1.0 CA B:CYS737 4.3 252.6 1.0 C B:CYS740 4.5 262.2 1.0 C B:PHE739 4.5 251.0 1.0 CD2 B:PHE739 4.7 251.0 1.0 N B:GLY741 4.7 243.1 1.0 CB B:PHE739 4.8 251.0 1.0 N B:PHE739 4.9 251.0 1.0 C B:GLY777 4.9 262.4 1.0 CA B:CYS775 5.0 267.4 1.0 C B:CYS737 5.0 252.6 1.0

Zinc binding site 6 out of 16 in the Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1002 b:208.6 occ:1.00 ND1 B:HIS838 2.0 162.0 1.0 ND1 B:HIS835 2.0 164.1 1.0 SG B:CYS785 2.3 171.1 1.0 SG B:CYS788 2.3 161.9 1.0 CG B:HIS835 2.5 164.1 1.0 CB B:HIS835 2.5 164.1 1.0 CE1 B:HIS838 2.8 162.0 1.0 CG B:HIS838 3.0 162.0 1.0 CE1 B:HIS835 3.2 164.1 1.0 N B:HIS835 3.2 164.1 1.0 CB B:CYS785 3.3 171.1 1.0 CA B:HIS835 3.4 164.1 1.0 CB B:HIS838 3.5 162.0 1.0 CD2 B:HIS835 3.7 164.1 1.0 CB B:CYS788 3.7 161.9 1.0 NE2 B:HIS838 4.0 162.0 1.0 NE2 B:HIS835 4.0 164.1 1.0 CD2 B:HIS838 4.1 162.0 1.0 N B:CYS788 4.2 161.9 1.0 C B:HIS835 4.4 164.1 1.0 O B:HIS835 4.4 164.1 1.0 C B:GLY834 4.5 160.7 1.0 CA B:CYS788 4.6 161.9 1.0 CA B:CYS785 4.6 171.1 1.0 CA B:HIS838 4.9 162.0 1.0 CA B:GLY834 4.9 160.7 1.0 CB B:LEU787 4.9 151.1 1.0

Zinc binding site 7 out of 16 in the Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1003 b:272.9 occ:1.00 CB B:CYS830 2.1 225.5 1.0 SG B:CYS830 2.3 225.5 1.0 SG B:CYS856 2.3 204.9 1.0 SG B:CYS827 2.3 215.7 1.0 SG B:CYS858 2.3 214.3 1.0 N B:CYS830 2.4 225.5 1.0 CA B:CYS830 2.7 225.5 1.0 CB B:CYS856 2.8 204.9 1.0 C B:ASN829 3.5 212.8 1.0 CB B:CYS827 3.6 215.7 1.0 ZN B:ZN1004 3.6 253.5 1.0 CB B:ASN829 3.7 212.8 1.0 C B:CYS830 3.9 225.5 1.0 CA B:ASN829 4.0 212.8 1.0 CB B:CYS858 4.1 214.3 1.0 CA B:CYS856 4.3 204.9 1.0 O B:CYS827 4.3 215.7 1.0 N B:ASN829 4.3 212.8 1.0 CG B:ASN829 4.4 212.8 1.0 N B:ARG831 4.4 203.2 1.0 O B:ASN829 4.4 212.8 1.0 ND2 B:ASN829 4.5 212.8 1.0 C B:CYS856 4.7 204.9 1.0 C B:CYS827 4.7 215.7 1.0 CA B:CYS858 4.7 214.3 1.0 O B:CYS830 4.8 225.5 1.0 CA B:CYS827 4.8 215.7 1.0 O B:CYS856 4.8 204.9 1.0 N B:CYS858 4.9 214.3 1.0 SG B:CYS854 4.9 181.1 1.0

Zinc binding site 8 out of 16 in the Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1004 b:253.5 occ:1.00 ND1 B:HIS832 2.0 196.8 1.0 CB B:CYS830 2.1 225.5 1.0 SG B:CYS854 2.3 181.1 1.0 SG B:CYS849 2.3 175.5 1.0 SG B:CYS830 2.3 225.5 1.0 CE1 B:HIS832 2.8 196.8 1.0 CG B:HIS832 3.1 196.8 1.0 CB B:CYS849 3.1 175.5 1.0 CA B:CYS830 3.4 225.5 1.0 O B:CYS830 3.6 225.5 1.0 CB B:HIS832 3.6 196.8 1.0 ZN B:ZN1003 3.6 272.9 1.0 CB B:CYS854 3.8 181.1 1.0 C B:CYS830 3.8 225.5 1.0 NE2 B:HIS832 3.9 196.8 1.0 CD2 B:HIS832 4.1 196.8 1.0 CB B:CYS856 4.3 204.9 1.0 N B:HIS832 4.5 196.8 1.0 N B:CYS830 4.5 225.5 1.0 CA B:CYS849 4.6 175.5 1.0 SG B:CYS858 4.6 214.3 1.0 CA B:HIS832 4.7 196.8 1.0 N B:ARG831 4.8 203.2 1.0

Zinc binding site 9 out of 16 in the Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1001 b:206.7 occ:1.00 SG C:CYS722 2.3 155.4 1.0 SG C:CYS736 2.3 149.5 1.0 SG C:CYS719 2.3 150.1 1.0 SG C:CYS733 2.3 148.9 1.0 CB C:CYS719 2.7 150.1 1.0 CB C:CYS733 3.0 148.9 1.0 CB C:CYS736 3.2 149.5 1.0 CB C:CYS722 3.6 155.4 1.0 N C:CYS722 3.8 155.4 1.0 CA C:CYS719 4.2 150.1 1.0 CA C:CYS722 4.3 155.4 1.0 N C:CYS736 4.4 149.5 1.0 CA C:CYS736 4.4 149.5 1.0 CA C:CYS733 4.4 148.9 1.0 CB C:HIS721 4.6 148.4 1.0 C C:CYS719 4.7 150.1 1.0 C C:HIS721 4.9 148.4 1.0 N C:HIS721 4.9 148.4 1.0 O C:CYS719 4.9 150.1 1.0 N C:CYS719 5.0 150.1 1.0

Zinc binding site 10 out of 16 in the Human GATOR2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 10 of Human GATOR2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1002 b:130.5 occ:1.00 ND1 C:HIS768 2.0 98.5 1.0 ND1 C:HIS765 2.0 95.8 1.0 SG C:CYS746 2.2 105.8 1.0 SG C:CYS743 2.2 108.5 1.0 CE1 C:HIS768 2.7 98.5 1.0 CB C:CYS743 2.9 108.5 1.0 CE1 C:HIS765 2.9 95.8 1.0 CG C:HIS765 3.1 95.8 1.0 CG C:HIS768 3.2 98.5 1.0 CB C:CYS746 3.2 105.8 1.0 CB C:HIS765 3.5 95.8 1.0 N C:CYS746 3.6 105.8 1.0 CB C:HIS768 3.7 98.5 1.0 NE2 C:HIS768 3.9 98.5 1.0 CA C:CYS746 4.0 105.8 1.0 NE2 C:HIS765 4.0 95.8 1.0 CD2 C:HIS765 4.1 95.8 1.0 N C:HIS765 4.2 95.8 1.0 CD2 C:HIS768 4.2 98.5 1.0 CA C:CYS743 4.3 108.5 1.0 CA C:HIS765 4.5 95.8 1.0 CB C:VAL745 4.7 96.7 1.0 C C:VAL745 4.7 96.7 1.0 N C:VAL745 4.8 96.7 1.0 C C:CYS746 4.8 105.8 1.0 C C:CYS743 4.9 108.5 1.0 CA C:VAL745 5.0 96.7 1.0

M.L.Valenstein, K.B.Rogala, P.V.Lalgudi, E.J.Brignole, X.Gu, R.A.Saxton, L.Chantranupong, J.Kolibius, J.P.Quast, D.M.Sabatini. Structure of the Nutrient-Sensing Hub GATOR2. Nature V. 607 610 2022.
ISSN: ESSN 1476-4687
PubMed: 35831510
DOI: 10.1038/S41586-022-04939-Z