Zinc in PDB 7uhp: Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (2000 Ms Snapshot)

All present enzymatic activity of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (2000 Ms Snapshot):
3.5.2.6;

The structure of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (2000 Ms Snapshot), PDB code: 7uhp was solved by M.Wilamowski, Y.Kim, D.A.Sherrell, A.Lavens, R.Henning, N.Maltseva, M.Endres, G.Babnigg, V.Srajer, A.Joachimiak, Center For Structuralgenomics Of Infectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.65 / 2.60
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	105.853, 105.853, 99.1, 90, 90, 120
R / Rfree (%)	25.1 / 27.5

The binding sites of Zinc atom in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (2000 Ms Snapshot) (pdb code 7uhp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (2000 Ms Snapshot), PDB code: 7uhp:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (2000 Ms Snapshot)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (2000 Ms Snapshot) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:4.2 occ:0.88 O10 A:XQP303 2.1 4.2 0.9 ND1 A:HIS107 2.5 2.9 1.0 NE2 A:HIS181 2.5 3.5 1.0 NE2 A:HIS105 2.7 2.5 1.0 ZN A:ZN302 3.0 1.3 1.0 C1 A:XQP303 3.2 5.2 0.9 CD2 A:HIS181 3.4 3.1 1.0 CG A:HIS107 3.4 2.4 1.0 CE1 A:HIS107 3.4 3.0 1.0 O3 A:XQP303 3.4 5.0 0.9 O8 A:XQP303 3.5 3.6 0.9 N1 A:XQP303 3.5 4.9 0.9 CD2 A:HIS105 3.5 2.3 1.0 CE1 A:HIS181 3.6 4.0 1.0 OD1 A:ASP109 3.6 2.9 1.0 CB A:HIS107 3.6 2.5 1.0 CE1 A:HIS105 3.6 2.6 1.0 C7 A:XQP303 3.8 5.4 0.9 C6 A:XQP303 3.8 5.4 0.9 CD2 A:HIS110 4.0 2.4 1.0 NE2 A:HIS110 4.1 2.5 1.0 C20 A:XQP303 4.1 4.1 0.9 C5 A:XQP303 4.2 5.2 0.9 C2 A:XQP303 4.2 5.6 0.9 OD2 A:ASP109 4.2 2.6 1.0 O1 A:XQP303 4.3 5.2 0.9 CG A:ASP109 4.3 2.7 1.0 CD2 A:HIS107 4.5 2.9 1.0 NE2 A:HIS107 4.5 3.0 1.0 CG A:HIS181 4.6 3.0 1.0 ND1 A:HIS181 4.6 3.4 1.0 CG A:HIS105 4.7 2.1 1.0 ND1 A:HIS105 4.7 2.1 1.0

Zinc binding site 2 out of 2 in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (2000 Ms Snapshot)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (2000 Ms Snapshot) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:1.3 occ:1.00 OD2 A:ASP109 1.9 2.6 1.0 N1 A:XQP303 2.2 4.9 0.9 NE2 A:HIS110 2.3 2.5 1.0 O8 A:XQP303 2.3 3.6 0.9 NE2 A:HIS246 2.5 4.2 1.0 CG A:ASP109 2.8 2.7 1.0 ZN A:ZN301 3.0 4.2 0.9 C2 A:XQP303 3.0 5.6 0.9 OD1 A:ASP109 3.0 2.9 1.0 C20 A:XQP303 3.1 4.1 0.9 CD2 A:HIS110 3.1 2.4 1.0 CE1 A:HIS110 3.2 2.7 1.0 C5 A:XQP303 3.2 5.2 0.9 CD2 A:HIS246 3.4 4.2 1.0 CE1 A:HIS246 3.5 4.4 1.0 O10 A:XQP303 3.7 4.2 0.9 O3 A:XQP303 3.8 5.0 0.9 C6 A:XQP303 4.0 5.4 0.9 NE2 A:HIS105 4.2 2.5 1.0 CB A:ASP109 4.2 2.6 1.0 C1 A:XQP303 4.3 5.2 0.9 O9 A:XQP303 4.3 3.5 0.9 CG A:HIS110 4.3 1.8 1.0 C3 A:XQP303 4.3 6.4 0.9 ND1 A:HIS110 4.3 2.1 1.0 O2 A:XQP303 4.4 5.5 0.9 CE1 A:HIS105 4.4 2.6 1.0 ND1 A:HIS246 4.6 4.2 1.0 CG A:HIS246 4.6 3.7 1.0 NE2 A:HIS181 4.7 3.5 1.0 CH2 A:TRP38 4.8 5.1 1.0 OG A:SER206 4.9 2.8 1.0 C4 A:XQP303 4.9 5.9 0.9 C7 A:XQP303 5.0 5.4 0.9 CZ3 A:TRP38 5.0 5.5 1.0

M.Wilamowski, Y.Kim, D.A.Sherrell, A.Lavens, R.Henning, N.Maltseva, M.Endres, G.Babnigg, V.Srajer, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid). Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (2000 Ms Snapshot) To Be Published.