Zinc in PDB 7uho: Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (500 Ms Snapshot)

All present enzymatic activity of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (500 Ms Snapshot):
3.5.2.6;

The structure of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (500 Ms Snapshot), PDB code: 7uho was solved by M.Wilamowski, Y.Kim, D.A.Sherrell, A.Lavens, R.Henning, N.Maltseva, M.Endres, G.Babnigg, V.Srajer, A.Joachimiak, Center For Structuralgenomics Of Infectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	31.08 / 2.20
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	105.853, 105.853, 99.1, 90, 90, 120
R / Rfree (%)	20.6 / 25.2

The binding sites of Zinc atom in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (500 Ms Snapshot) (pdb code 7uho). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (500 Ms Snapshot), PDB code: 7uho:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (500 Ms Snapshot)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (500 Ms Snapshot) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:18.6 occ:0.49 O10 A:XQP403 2.1 21.0 0.8 NE2 A:HIS192 2.3 19.7 1.0 ND1 A:HIS118 2.3 12.4 1.0 NE2 A:HIS116 2.3 17.6 1.0 CD2 A:HIS192 2.8 14.3 1.0 CD2 A:HIS116 3.1 11.9 1.0 CE1 A:HIS118 3.3 8.9 1.0 CG A:HIS118 3.3 11.2 1.0 ZN A:ZN402 3.3 21.7 0.8 CE1 A:HIS116 3.3 10.3 1.0 C1 A:XQP403 3.3 22.7 0.8 O8 A:XQP403 3.4 22.5 0.8 CE1 A:HIS192 3.5 17.8 1.0 CB A:HIS118 3.6 10.5 1.0 N1 A:XQP403 3.7 17.8 0.8 OD1 A:ASP120 4.0 14.8 1.0 O3 A:XQP403 4.1 19.6 0.8 CD2 A:HIS121 4.1 13.8 1.0 CG A:HIS192 4.1 13.7 1.0 O1 A:XQP403 4.1 21.6 0.8 NE2 A:HIS121 4.2 13.6 1.0 C20 A:XQP403 4.2 20.8 0.8 C6 A:XQP403 4.2 23.6 0.8 CG A:HIS116 4.3 7.0 1.0 ND1 A:HIS116 4.3 9.7 1.0 NE2 A:HIS118 4.4 10.7 1.0 ND1 A:HIS192 4.4 16.9 1.0 CD2 A:HIS118 4.4 11.6 1.0 C2 A:XQP403 4.4 17.4 0.8 C7 A:XQP403 4.5 20.1 0.8 C5 A:XQP403 4.6 21.4 0.8 OD2 A:ASP120 4.6 15.2 1.0 CG A:ASP120 4.7 11.8 1.0

Zinc binding site 2 out of 2 in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (500 Ms Snapshot)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (500 Ms Snapshot) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn402 b:21.7 occ:0.78 OD2 A:ASP120 2.1 15.2 1.0 N1 A:XQP403 2.2 17.8 0.8 NE2 A:HIS121 2.3 13.6 1.0 NE2 A:HIS257 2.3 18.4 1.0 O8 A:XQP403 2.4 22.5 0.8 C2 A:XQP403 3.0 17.4 0.8 CG A:ASP120 3.0 11.8 1.0 C20 A:XQP403 3.0 20.8 0.8 CE1 A:HIS121 3.2 12.6 1.0 OD1 A:ASP120 3.2 14.8 1.0 CD2 A:HIS121 3.2 13.8 1.0 CE1 A:HIS257 3.2 21.3 1.0 C5 A:XQP403 3.3 21.4 0.8 ZN A:ZN401 3.3 18.6 0.5 CD2 A:HIS257 3.3 13.3 1.0 O10 A:XQP403 3.7 21.0 0.8 O3 A:XQP403 3.9 19.6 0.8 C6 A:XQP403 4.0 23.6 0.8 C1 A:XQP403 4.1 22.7 0.8 NE2 A:HIS116 4.1 17.6 1.0 C3 A:XQP403 4.2 22.0 0.8 O9 A:XQP403 4.2 15.6 0.8 ND1 A:HIS121 4.3 11.2 1.0 CE1 A:HIS116 4.4 10.3 1.0 CG A:HIS121 4.4 11.7 1.0 ND1 A:HIS257 4.4 10.3 1.0 CB A:ASP120 4.4 12.1 1.0 CG A:HIS257 4.4 14.7 1.0 O2 A:XQP403 4.4 21.5 0.8 NE2 A:HIS192 4.6 19.7 1.0 OG A:SER217 4.7 20.4 1.0 C4 A:XQP403 4.9 20.1 0.8

M.Wilamowski, Y.Kim, D.A.Sherrell, A.Lavens, R.Henning, N.Maltseva, M.Endres, G.Babnigg, V.Srajer, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid). Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Cleaved Moxalactam (500 Ms Snapshot) To Be Published.