Zinc in PDB 7uhj: Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (60 Ms Snapshot)

All present enzymatic activity of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (60 Ms Snapshot):
3.5.2.6;

The structure of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (60 Ms Snapshot), PDB code: 7uhj was solved by M.Wilamowski, Y.Kim, D.A.Sherrell, A.Lavens, R.Henning, N.Maltseva, M.Endres, G.Babnigg, V.Srajer, A.Joachimiak, Center For Structuralgenomics Of Infectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.39 / 2.20
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	105.853, 105.853, 99.1, 90, 90, 120
R / Rfree (%)	20.3 / 23.8

The binding sites of Zinc atom in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (60 Ms Snapshot) (pdb code 7uhj). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (60 Ms Snapshot), PDB code: 7uhj:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (60 Ms Snapshot)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (60 Ms Snapshot) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:19.1 occ:0.53 ND1 A:HIS107 2.2 16.2 1.0 NE2 A:HIS105 2.2 17.4 1.0 NE2 A:HIS181 2.4 19.5 1.0 O1 A:MX0303 2.6 23.7 0.8 CD2 A:HIS181 2.9 16.6 1.0 O7 A:MX0303 3.1 21.1 0.8 CE1 A:HIS107 3.1 13.4 1.0 CE1 A:HIS105 3.1 13.5 1.0 CD2 A:HIS105 3.1 13.2 1.0 C1 A:MX0303 3.2 25.6 0.8 CG A:HIS107 3.2 14.5 1.0 ZN A:ZN302 3.4 15.2 0.7 CB A:HIS107 3.5 13.1 1.0 CE1 A:HIS181 3.7 19.8 1.0 N1 A:MX0303 3.7 29.7 0.8 OD1 A:ASP109 4.0 18.3 1.0 C13 A:MX0303 4.1 24.4 0.8 ND1 A:HIS105 4.2 10.9 1.0 CG A:HIS181 4.2 11.4 1.0 CD2 A:HIS110 4.2 15.0 1.0 O3 A:MX0303 4.2 27.7 0.8 CG A:HIS105 4.2 11.6 1.0 C7 A:MX0303 4.2 25.4 0.8 NE2 A:HIS107 4.2 14.3 1.0 C6 A:MX0303 4.3 32.6 0.8 CD2 A:HIS107 4.3 12.9 1.0 C2 A:MX0303 4.3 25.7 0.8 NE2 A:HIS110 4.4 17.1 1.0 ND1 A:HIS181 4.5 18.4 1.0 C5 A:MX0303 4.7 28.3 0.8 OD2 A:ASP109 4.7 15.9 1.0 CG A:ASP109 4.8 16.2 1.0

Zinc binding site 2 out of 2 in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (60 Ms Snapshot)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (60 Ms Snapshot) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:15.2 occ:0.73 OD2 A:ASP109 2.1 15.9 1.0 NE2 A:HIS110 2.2 17.1 1.0 NE2 A:HIS246 2.3 21.0 1.0 O7 A:MX0303 2.5 21.1 0.8 N1 A:MX0303 2.8 29.7 0.8 CG A:ASP109 3.0 16.2 1.0 CD2 A:HIS110 3.1 15.0 1.0 C13 A:MX0303 3.1 24.4 0.8 C2 A:MX0303 3.2 25.7 0.8 C5 A:MX0303 3.2 28.3 0.8 OD1 A:ASP109 3.2 18.3 1.0 CE1 A:HIS246 3.2 18.5 1.0 CE1 A:HIS110 3.3 15.4 1.0 CD2 A:HIS246 3.3 20.1 1.0 ZN A:ZN301 3.4 19.1 0.5 C1 A:MX0303 3.4 25.6 0.8 C6 A:MX0303 3.9 32.6 0.8 O3 A:MX0303 4.0 27.7 0.8 O1 A:MX0303 4.1 23.7 0.8 NE2 A:HIS105 4.1 17.4 1.0 O8 A:MX0303 4.1 23.7 0.8 CE1 A:HIS105 4.1 13.5 1.0 CG A:HIS110 4.2 13.1 1.0 O2 A:MX0303 4.3 29.5 0.8 ND1 A:HIS110 4.3 13.0 1.0 C3 A:MX0303 4.3 24.7 0.8 CB A:ASP109 4.4 14.8 1.0 ND1 A:HIS246 4.4 19.9 1.0 CG A:HIS246 4.5 18.4 1.0 NE2 A:HIS181 4.7 19.5 1.0 OG A:SER206 4.9 21.6 1.0 CH2 A:TRP38 4.9 21.0 1.0 C4 A:MX0303 4.9 26.4 0.8 C7 A:MX0303 5.0 25.4 0.8

M.Wilamowski, Y.Kim, D.A.Sherrell, A.Lavens, R.Henning, N.Maltseva, M.Endres, G.Babnigg, V.Srajer, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid). Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (60 Ms Snapshot) To Be Published.