Zinc in PDB 7uhh: Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (20 Ms Snapshot)

All present enzymatic activity of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (20 Ms Snapshot):
3.5.2.6;

The structure of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (20 Ms Snapshot), PDB code: 7uhh was solved by M.Wilamowski, Y.Kim, D.A.Sherrell, A.Lavens, R.Henning, N.Maltseva, M.Endres, G.Babnigg, V.Srajer, A.Joachimiak, Center For Structuralgenomics Of Infectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.03 / 2.20
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	105.853, 105.853, 99.1, 90, 90, 120
R / Rfree (%)	22.3 / 26.2

The binding sites of Zinc atom in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (20 Ms Snapshot) (pdb code 7uhh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (20 Ms Snapshot), PDB code: 7uhh:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (20 Ms Snapshot)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (20 Ms Snapshot) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:17.6 occ:0.59 NE2 A:HIS181 2.3 18.5 1.0 ND1 A:HIS107 2.4 10.6 1.0 NE2 A:HIS105 2.4 14.7 1.0 O1 A:MX0303 2.8 21.3 0.7 O7 A:MX0303 2.9 21.6 0.7 C1 A:MX0303 3.2 21.6 0.7 CD2 A:HIS181 3.2 18.3 1.0 ZN A:ZN302 3.2 14.4 0.6 CG A:HIS107 3.3 10.2 1.0 CE1 A:HIS181 3.3 18.8 1.0 CE1 A:HIS105 3.3 14.7 1.0 CD2 A:HIS105 3.4 14.3 1.0 CB A:HIS107 3.4 10.2 1.0 CE1 A:HIS107 3.4 10.6 1.0 OD1 A:ASP109 3.6 20.9 1.0 N1 A:MX0303 3.7 21.6 0.7 CD2 A:HIS110 3.9 21.0 1.0 C13 A:MX0303 3.9 21.5 0.7 NE2 A:HIS110 3.9 21.9 1.0 C7 A:MX0303 4.1 22.0 0.7 O3 A:MX0303 4.1 22.0 0.7 C2 A:MX0303 4.3 21.4 0.7 C6 A:MX0303 4.3 22.3 0.7 OD2 A:ASP109 4.4 21.7 1.0 CG A:HIS181 4.4 18.2 1.0 ND1 A:HIS181 4.4 18.7 1.0 CG A:ASP109 4.4 20.8 1.0 CD2 A:HIS107 4.4 10.1 1.0 ND1 A:HIS105 4.5 14.5 1.0 NE2 A:HIS107 4.5 10.3 1.0 CG A:HIS105 4.5 14.2 1.0 C5 A:MX0303 4.7 21.7 0.7 CA A:HIS107 4.9 10.9 1.0 O8 A:MX0303 5.0 21.6 0.7

Zinc binding site 2 out of 2 in the Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (20 Ms Snapshot)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (20 Ms Snapshot) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:14.4 occ:0.58 NE2 A:HIS110 2.1 21.9 1.0 OD2 A:ASP109 2.2 21.7 1.0 O7 A:MX0303 2.3 21.6 0.7 NE2 A:HIS246 2.5 19.4 1.0 N1 A:MX0303 2.8 21.6 0.7 C13 A:MX0303 2.8 21.5 0.7 C2 A:MX0303 2.9 21.4 0.7 CE1 A:HIS110 3.0 21.6 1.0 CG A:ASP109 3.1 20.8 1.0 CD2 A:HIS110 3.2 21.0 1.0 ZN A:ZN301 3.2 17.6 0.6 CD2 A:HIS246 3.3 19.4 1.0 C5 A:MX0303 3.3 21.7 0.7 OD1 A:ASP109 3.4 20.9 1.0 C1 A:MX0303 3.5 21.6 0.7 CE1 A:HIS246 3.5 19.6 1.0 O8 A:MX0303 3.8 21.6 0.7 C3 A:MX0303 3.9 21.3 0.7 O1 A:MX0303 4.1 21.3 0.7 C6 A:MX0303 4.1 22.3 0.7 ND1 A:HIS110 4.1 21.1 1.0 O3 A:MX0303 4.2 22.0 0.7 CG A:HIS110 4.2 20.0 1.0 NE2 A:HIS105 4.3 14.7 1.0 O2 A:MX0303 4.4 22.0 0.7 CE1 A:HIS105 4.4 14.7 1.0 CG A:HIS246 4.5 19.2 1.0 CB A:ASP109 4.5 19.5 1.0 ND1 A:HIS246 4.6 19.7 1.0 OG A:SER206 4.6 25.1 1.0 NE2 A:HIS181 4.7 18.5 1.0 C4 A:MX0303 4.8 21.7 0.7 C12 A:MX0303 4.8 21.0 0.7

M.Wilamowski, Y.Kim, D.A.Sherrell, A.Lavens, R.Henning, N.Maltseva, M.Endres, G.Babnigg, V.Srajer, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid). Time-Resolved Structure of Metallo Beta-Lactamase L1 in A Complex with Non-Hydrolyzed Moxalactam (20 Ms Snapshot) To Be Published.