Zinc in PDB 7uae: Human Meprin Alpha (Active State)

Enzymatic activity of Human Meprin Alpha (Active State)

All present enzymatic activity of Human Meprin Alpha (Active State):
3.4.24.18;

Other elements in 7uae:

The structure of Human Meprin Alpha (Active State) also contains other interesting chemical elements:

Calcium (Ca) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Meprin Alpha (Active State) (pdb code 7uae). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Meprin Alpha (Active State), PDB code: 7uae:

Zinc binding site 1 out of 1 in 7uae

Go back to Zinc Binding Sites List in 7uae
Zinc binding site 1 out of 1 in the Human Meprin Alpha (Active State)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Meprin Alpha (Active State) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn702

b:76.8
occ:1.00
NE2 A:HIS165 1.8 68.6 1.0
NE2 A:HIS155 1.8 68.3 1.0
NE2 A:HIS159 1.9 67.6 1.0
CD2 A:HIS165 2.8 68.6 1.0
CD2 A:HIS155 2.8 68.3 1.0
CE1 A:HIS159 2.8 67.6 1.0
CE1 A:HIS165 2.8 68.6 1.0
CE1 A:HIS155 2.9 68.3 1.0
CD2 A:HIS159 3.0 67.6 1.0
CG A:HIS165 3.9 68.6 1.0
ND1 A:HIS165 3.9 68.6 1.0
CG A:HIS155 3.9 68.3 1.0
ND1 A:HIS159 4.0 67.6 1.0
ND1 A:HIS155 4.0 68.3 1.0
CG A:HIS159 4.1 67.6 1.0
OE2 A:GLU156 4.2 69.9 1.0
CE1 A:TYR214 4.5 66.1 1.0
OH A:TYR214 4.6 66.1 1.0
CE A:MET212 4.8 69.6 1.0
OE1 A:GLU156 4.9 69.9 1.0
CD A:GLU156 4.9 69.9 1.0

Reference:

C.Bayly-Jones, C.J.Lupton, C.Fritz, H.Venugopal, D.Ramsbeck, M.Wermann, C.Jager, A.De Marco, S.Schilling, D.Schlenzig, J.C.Whisstock. Helical Ultrastructure of the Metalloprotease Meprin Alpha in Complex with A Small Molecule Inhibitor. Nat Commun V. 13 6178 2022.
ISSN: ESSN 2041-1723
PubMed: 36261433
DOI: 10.1038/S41467-022-33893-7
Page generated: Sat Apr 8 03:59:36 2023

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