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Zinc in PDB 7u5c: Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State

Enzymatic activity of Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State

All present enzymatic activity of Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State:
2.7.7.7;

Other elements in 7u5c:

The structure of Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State also contains other interesting chemical elements:

Iron (Fe) 4 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State (pdb code 7u5c). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State, PDB code: 7u5c:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 7u5c

Go back to Zinc Binding Sites List in 7u5c
Zinc binding site 1 out of 4 in the Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:229.6
occ:1.00
O A:CYS121 2.3 153.0 1.0
C A:CYS121 2.3 153.0 1.0
CB A:CYS121 2.4 153.0 1.0
SG A:CYS128 2.5 133.6 1.0
CA A:CYS121 2.7 153.0 1.0
SG A:CYS122 2.8 164.5 1.0
N A:CYS122 3.1 164.5 1.0
SG A:CYS121 3.2 153.0 1.0
CB A:CYS128 3.3 133.6 1.0
CB A:CYS122 3.6 164.5 1.0
CA A:CYS122 3.8 164.5 1.0
N A:CYS121 4.1 153.0 1.0
CD A:LYS130 4.2 135.2 1.0
CA A:CYS128 4.5 133.6 1.0
N A:CYS128 4.6 133.6 1.0
CB A:LYS130 4.8 135.2 1.0
CE A:LYS130 4.9 135.2 1.0
CG A:LYS130 5.0 135.2 1.0

Zinc binding site 2 out of 4 in 7u5c

Go back to Zinc Binding Sites List in 7u5c
Zinc binding site 2 out of 4 in the Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1501

b:123.9
occ:1.00
N C:CYS1374 2.0 59.3 1.0
SG C:CYS1374 2.3 59.3 1.0
CB C:CYS1374 2.4 59.3 1.0
SG C:CYS1371 2.4 40.7 1.0
SG C:CYS1353 2.4 51.9 1.0
CA C:CYS1374 2.6 59.3 1.0
C C:ALA1373 3.2 52.6 1.0
CB C:CYS1371 3.4 40.7 1.0
CB C:ALA1373 3.4 52.6 1.0
CA C:ALA1373 3.6 52.6 1.0
C C:CYS1374 3.6 59.3 1.0
CB C:CYS1353 3.7 51.9 1.0
N C:ALA1373 3.8 52.6 1.0
O C:CYS1374 3.9 59.3 1.0
O C:ALA1373 4.2 52.6 1.0
CA C:CYS1371 4.7 40.7 1.0
N C:MET1375 4.7 83.7 1.0
SG C:CYS1348 4.7 44.3 1.0
C C:CYS1371 4.7 40.7 1.0
C C:PRO1372 4.9 40.3 1.0

Zinc binding site 3 out of 4 in 7u5c

Go back to Zinc Binding Sites List in 7u5c
Zinc binding site 3 out of 4 in the Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1502

b:51.9
occ:1.00
SG C:CYS1286 2.3 31.6 1.0
SG C:CYS1283 2.3 29.9 1.0
SG C:CYS1310 2.4 35.6 1.0
CB C:CYS1286 2.5 31.6 1.0
CB C:CYS1310 3.1 35.6 1.0
N C:CYS1286 3.4 31.6 1.0
SG C:CYS1315 3.5 60.5 1.0
CA C:CYS1286 3.5 31.6 1.0
CB C:CYS1283 3.6 29.9 1.0
CB C:CYS1315 4.3 60.5 1.0
C C:CYS1286 4.5 31.6 1.0
CA C:CYS1310 4.6 35.6 1.0
C C:THR1285 4.7 28.8 1.0
CB C:ALA1317 4.8 62.0 1.0
N C:GLY1287 4.9 33.2 1.0
CA C:CYS1283 5.0 29.9 1.0

Zinc binding site 4 out of 4 in 7u5c

Go back to Zinc Binding Sites List in 7u5c
Zinc binding site 4 out of 4 in the Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn1301

b:253.1
occ:1.00
O E:SER1048 1.9 144.7 1.0
O E:ILE1049 2.0 150.9 1.0
C E:ILE1049 2.3 150.9 1.0
SG E:CYS1050 2.4 153.3 1.0
CB E:CYS1055 2.5 155.7 1.0
SG E:CYS1055 2.5 155.7 1.0
C E:SER1048 2.7 144.7 1.0
N E:CYS1050 2.7 153.3 1.0
CA E:CYS1055 2.9 155.7 1.0
CA E:CYS1050 3.1 153.3 1.0
N E:ILE1049 3.2 150.9 1.0
CB E:CYS1050 3.2 153.3 1.0
CA E:ILE1049 3.3 150.9 1.0
CA E:SER1048 3.8 144.7 1.0
N E:CYS1055 3.9 155.7 1.0
CB E:SER1048 4.0 144.7 1.0
N E:THR1056 4.0 150.8 1.0
C E:CYS1055 4.0 155.7 1.0
N E:CYS1043 4.0 131.4 1.0
OG E:SER1048 4.1 144.7 1.0
CA E:VAL1042 4.3 125.3 1.0
N E:SER1048 4.3 144.7 1.0
CB E:CYS1043 4.4 131.4 1.0
O E:TRP1041 4.5 121.2 1.0
C E:VAL1042 4.5 125.3 1.0
CB E:ILE1049 4.5 150.9 1.0
C E:CYS1050 4.6 153.3 1.0
C E:LYS1054 4.6 128.8 1.0
CA E:CYS1043 4.7 131.4 1.0
O E:LYS1054 4.8 128.8 1.0
CB E:VAL1042 4.9 125.3 1.0
CG1 E:VAL1042 5.0 125.3 1.0

Reference:

S.W.Cai, J.C.Zinder, V.Svetlov, M.W.Bush, E.Nudler, T.Walz, T.De Lange. Cryo-Em Structure of the Human Cst-Pol Alpha /Primase Complex in A Recruitment State. Nat.Struct.Mol.Biol. V. 29 813 2022.
ISSN: ESSN 1545-9985
PubMed: 35578024
DOI: 10.1038/S41594-022-00766-Y
Page generated: Sat Apr 8 03:53:14 2023

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