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Atomistry » Zinc » PDB 7spz-7t0c » 7sv8 » |
Zinc in PDB 7sv8: Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Furan-2-Ylmethyl) (4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino)Propanoic AcidEnzymatic activity of Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Furan-2-Ylmethyl) (4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino)Propanoic Acid
All present enzymatic activity of Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Furan-2-Ylmethyl) (4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino)Propanoic Acid:
4.2.1.1; Protein crystallography data
The structure of Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Furan-2-Ylmethyl) (4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino)Propanoic Acid, PDB code: 7sv8
was solved by
J.E.Combs,
R.Mckenna,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Furan-2-Ylmethyl) (4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino)Propanoic Acid
(pdb code 7sv8). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Furan-2-Ylmethyl) (4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino)Propanoic Acid, PDB code: 7sv8: Zinc binding site 1 out of 1 in 7sv8Go back to Zinc Binding Sites List in 7sv8
Zinc binding site 1 out
of 1 in the Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Furan-2-Ylmethyl) (4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino)Propanoic Acid
Mono view Stereo pair view
Reference:
A.Bonardi,
S.Bua,
J.Combs,
C.Lomelino,
J.Andring,
S.M.Osman,
A.Toti,
L.Di Cesare Mannelli,
P.Gratteri,
C.Ghelardini,
R.Mckenna,
A.Nocentini,
C.T.Supuran.
The Three-Tails Approach As A New Strategy to Improve Selectivity of Action of Sulphonamide Inhibitors Against Tumour-Associated Carbonic Anhydrase IX and XII. J Enzyme Inhib Med Chem V. 37 930 2022.
Page generated: Sat Apr 8 03:15:36 2023
ISSN: ESSN 1475-6374 PubMed: 35306936 DOI: 10.1080/14756366.2022.2053526 |
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