Atomistry » Zinc » PDB 7r44-7rhq » 7rbs
Atomistry »
  Zinc »
    PDB 7r44-7rhq »
      7rbs »

Zinc in PDB 7rbs: The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15

Enzymatic activity of The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15

All present enzymatic activity of The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15:
3.4.19.12;

Protein crystallography data

The structure of The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15, PDB code: 7rbs was solved by J.Osipiuk, C.Tesar, R.Jedrzejczak, M.Endres, A.Joachimiak, Center Forstructural Genomics Of Infectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.99 / 2.98
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 153.673, 220.87, 232.787, 90, 90, 90
R / Rfree (%) 19.5 / 23.6

Zinc Binding Sites:

The binding sites of Zinc atom in the The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15 (pdb code 7rbs). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15, PDB code: 7rbs:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in 7rbs

Go back to Zinc Binding Sites List in 7rbs
Zinc binding site 1 out of 5 in the The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:145.8
occ:0.60
 SG A:CYS224 2.3 141.6 1.0
SG A:CYS226 2.3 155.2 1.0
SG A:CYS189 2.4 126.6 1.0
SG A:CYS192 2.4 148.4 1.0
CB A:CYS189 3.3 118.6 1.0
CB A:CYS224 3.4 140.9 1.0
CB A:CYS226 3.4 149.7 1.0
CB A:CYS192 3.4 140.1 1.0
N A:CYS226 4.0 144.9 1.0
OG1 A:THR191 4.2 129.3 1.0
N A:CYS192 4.3 129.9 1.0
CA A:CYS226 4.3 146.8 1.0
CA A:CYS192 4.4 131.7 1.0
N A:THR225 4.6 143.8 1.0
CA A:CYS224 4.7 138.8 1.0
CA A:CYS189 4.7 112.2 1.0
C A:CYS224 4.9 142.2 1.0

Zinc binding site 2 out of 5 in 7rbs

Go back to Zinc Binding Sites List in 7rbs
Zinc binding site 2 out of 5 in the The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn501

b:136.2
occ:0.60
 SG C:CYS189 2.3 122.2 1.0
SG C:CYS224 2.4 130.7 1.0
SG C:CYS226 2.4 137.8 1.0
SG C:CYS192 2.4 139.3 1.0
CB C:CYS189 3.3 111.1 1.0
CB C:CYS226 3.4 138.3 1.0
CB C:CYS192 3.5 131.1 1.0
CB C:CYS224 3.5 128.2 1.0
N C:CYS226 3.9 135.8 1.0
CA C:CYS226 4.3 137.0 1.0
N C:CYS192 4.3 127.0 1.0
N C:THR225 4.4 131.5 1.0
OG1 C:THR191 4.4 130.1 1.0
CA C:CYS192 4.5 124.2 1.0
CA C:CYS189 4.6 105.6 1.0
CA C:CYS224 4.7 124.9 1.0
C C:CYS224 4.8 128.3 1.0
C C:THR225 4.9 133.1 1.0

Zinc binding site 3 out of 5 in 7rbs

Go back to Zinc Binding Sites List in 7rbs
Zinc binding site 3 out of 5 in the The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15 within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn501

b:147.3
occ:0.60
 SG E:CYS224 2.3 137.5 1.0
SG E:CYS226 2.4 151.8 1.0
SG E:CYS189 2.4 134.7 1.0
SG E:CYS192 2.4 146.5 1.0
CB E:CYS189 3.4 124.0 1.0
CB E:CYS224 3.4 136.1 1.0
CB E:CYS192 3.4 137.0 1.0
CB E:CYS226 3.4 145.8 1.0
N E:CYS226 3.7 137.8 1.0
CA E:CYS226 4.2 142.6 1.0
N E:CYS192 4.3 130.3 1.0
N E:THR225 4.3 135.6 1.0
OG1 E:THR191 4.3 133.6 1.0
CA E:CYS192 4.5 131.0 1.0
CA E:CYS224 4.5 133.9 1.0
C E:CYS224 4.6 136.9 1.0
CA E:CYS189 4.8 117.2 1.0
C E:THR225 4.8 135.0 1.0
CA E:THR225 4.9 133.7 1.0
CB E:THR225 4.9 132.2 1.0

Zinc binding site 4 out of 5 in 7rbs

Go back to Zinc Binding Sites List in 7rbs
Zinc binding site 4 out of 5 in the The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15 within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Zn501

b:144.1
occ:0.60
 SG G:CYS224 2.3 137.8 1.0
SG G:CYS189 2.4 125.9 1.0
SG G:CYS226 2.4 149.0 1.0
SG G:CYS192 2.4 143.8 1.0
CB G:CYS189 3.3 120.4 1.0
CB G:CYS224 3.3 136.3 1.0
CB G:CYS226 3.4 147.2 1.0
CB G:CYS192 3.4 139.5 1.0
N G:CYS226 4.0 144.1 1.0
OG1 G:THR191 4.0 127.1 1.0
N G:CYS192 4.1 130.9 1.0
CA G:CYS226 4.3 144.8 1.0
CA G:CYS192 4.3 135.0 1.0
N G:THR225 4.6 139.6 1.0
CA G:CYS224 4.7 134.3 1.0
CA G:CYS189 4.7 115.6 1.0
C G:CYS224 4.9 137.5 1.0

Zinc binding site 5 out of 5 in 7rbs

Go back to Zinc Binding Sites List in 7rbs
Zinc binding site 5 out of 5 in the The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15 within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Zn501

b:140.2
occ:0.60
 SG I:CYS224 2.3 137.9 1.0
SG I:CYS189 2.4 130.5 1.0
SG I:CYS192 2.4 138.7 1.0
SG I:CYS226 2.4 144.7 1.0
CB I:CYS189 3.3 119.6 1.0
CB I:CYS224 3.3 134.8 1.0
CB I:CYS192 3.4 132.1 1.0
CB I:CYS226 3.4 144.9 1.0
N I:CYS226 3.9 140.5 1.0
CA I:CYS226 4.3 142.8 1.0
N I:THR225 4.4 135.3 1.0
N I:CYS192 4.4 127.3 1.0
OG1 I:THR191 4.4 130.6 1.0
CA I:CYS192 4.5 126.2 1.0
CA I:CYS224 4.6 131.7 1.0
CA I:CYS189 4.7 113.8 1.0
C I:CYS224 4.7 133.4 1.0
C I:THR225 4.9 137.4 1.0

Reference:

J.Osipiuk, C.Tesar, R.Jedrzejczak, M.Endres, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid). The Crystal Structure of Papain-Like Protease of Sars Cov-2, C111S Mutant, in Complex with Human ISG15 To Be Published.
Page generated: Wed Oct 30 10:14:12 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy